| Chemical name: | 10-Deacetylbaccatin III |
CAS Number: |
32981-86-5 |
| Synonyms: |
10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP Impurity); 10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one 12b-acetate, 12-benzoate (USP); |
| Molecular form: | C29H36O10 |
| Appearance: | White Solid |
| Mol. Weight: | 544.6 |
| Storage: | 2-8°C Refrigerator |
Subtitle: Plant-Derived API Intermediate, CAS 32981-86-5 | GMP Certified, COA Provided
What is 10-Deacetylbaccatin III (10-DAB)?
10-Deacetylbaccatin III (C29H36O10) is a bioactive diterpenoid naturally extracted from the needles and bark of Taxus species (yew trees). As a key precursor in the semi-synthesis of paclitaxel, docetaxel, and other taxane-based chemotherapeutic agents, 10-DAB is widely utilized in pharmaceutical R&D and oncology drug production.
Key Specifications & Features
- Purity: ≥98% (HPLC-UV validated, COA available)
- Appearance: White to off-white crystalline powder
- Solubility: Soluble in methanol, ethanol, DMSO; slightly soluble in water
- Storage: Stable at -20°C in airtight containers, protected from light
- Plant Source: Sustainably harvested Taxus wallichiana (Himalayan yew)
Applications of 10-DAB
- Anticancer Drug Synthesis
- Critical intermediate for semi-synthetic production of paclitaxel (Taxol®) and docetaxel (Taxotere®).
- Used in R&D for novel taxane derivatives targeting drug-resistant cancers.
- Biochemical Research
- Study of tubulin polymerization mechanisms and apoptosis induction.
- Reference standard for analytical chemistry and quality control.
- Natural Product Extraction
- High-yield extraction process compliant with green chemistry principles.
Why Source 10-DAB from Us?
✅ Certified Quality:
- Batch-specific Certificate of Analysis (COA) with HPLC, MS, NMR data.
- Compliant with USP, EP, and ICH Q7 GMP guidelines.
✅ Sustainable Sourcing:
- Ethically harvested from cultivated Taxus plantations (CITES Appendix II compliant).
✅ Global Logistics:
- Seamless cold-chain shipping to USA, EU, and APAC regions.
- Customizable packaging (1g to 1kg, amber glass vials with desiccant).
Technical Support & Documentation
- Free MSDS (Material Safety Data Sheet) and stability data upon request.
- Custom synthesis and bulk pricing available for OEM partners.
- Dedicated regulatory support for IND/NDA submissions.
Safety & Compliance
- CAS Number: 32981-86-5
- Hazard Codes: Handle with PPE (gloves, goggles) – non-hazardous for professional use.
- Regulatory Status: REACH registered; DMF available for pharmaceutical clients.
FAQs for 10-DAB
Q: Can 10-DAB be used directly in cell culture studies?
A: No. It requires chemical modification (e.g., side-chain addition) to become bioactive taxanes.
Q: What’s the lead time for 500g orders?
A: Standard production time: 2-3 weeks. Express shipping available.
Q: Do you provide taxane synthesis protocols?
A: Yes! Technical whitepapers available for qualified clients.
Description:
Source 98% HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) – GMP-certified Taxus extract for paclitaxel synthesis. Bulk orders, COA/MSDS, and regulatory support included.
- Keywords:
- Primary: “10-Deacetylbaccatin III supplier”, “High purity 10-DAB”, “Paclitaxel precursor”
- Long-tail: “CAS 32981-86-5 price”, “Taxus extract for cancer research”, “GMP 10-DAB”
- Keywords:
- “Taxane intermediate”, “semi-synthetic paclitaxel”, “C29H36O10″, “yew tree compound”
