Product Name:10-Deacetylbaccatine III/10-DAB/10-Deacetylbaccatin III/Taxus Baccata Extract
Botanical Source:Taxus Baccata
CAS No: 32981-86-5
Specification:99% by HPLC
Appearance:White crystal Powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
10-Deacetylbaccatin III (10-DAB) Product Description
Product Overview
Chemical Name: 10-Deacetylbaccatin III (10-DAB)
CAS No.: 32981-86-5
Molecular Formula: C₂₉H₃₆O₁₀
Molecular Weight: 544.59 g/mol
Purity: ≥98% (HPLC)
Appearance: White to off-white crystalline powder
Target: Microtubule/Tubulin
Pathway: Cell Cycle/DNA Damage
Key Applications
10-Deacetylbaccatin III is a critical intermediate in the synthesis of Paclitaxel (Taxol®) and Docetaxel, widely used anticancer agents . It serves as a reference standard for analytical method development (AMV), quality control (QC), and regulatory compliance (e.g., EP/USP pharmacopeial standards) .
- Research Use: Studies on microtubule stabilization, antitumor mechanisms, and drug metabolism .
- Pharmaceutical Production: Key precursor in semisynthetic Taxane derivatives .
Physicochemical Properties
- Solubility:
- Soluble in DMSO (≥2.5 mg/mL, 4.59 mM) .
- Stable in formulations containing PEG300, Tween80, and saline for in vivo studies .
- Storage:Transport: Stable at room temperature for short-term shipping .
- Powder: Store at -20°C (3 years) or 4°C (2 years); protect from light and moisture .
- Solution: Store at -80°C (6 months) or -20°C (1 month); avoid repeated freeze-thaw cycles .
Safety and Handling
- Hazard Statements:
- Causes eye irritation (H319), suspected genetic defects (H341), and respiratory toxicity (H335) .
- Precautions:Usage Restriction: For research purposes only. Not for human or veterinary use .
- Wear lab coat, gloves, and eye protection during handling .
- Avoid inhalation, skin contact, or ingestion .
Packaging Options
Available in multiple sizes to meet diverse research needs:
- 10mg, 20mg, 50mg, 100mg, 500mg, 1g .
- Custom packaging available upon request .
Technical Support & Compliance
- Certification: Compliant with EP/USP standards; Certificate of Analysis (COA) provided .
- References: Supported by peer-reviewed studies on Taxoid synthesis and bioactivity .
Keywords
10-Deacetylbaccatin III, CAS 32981-86-5, Paclitaxel Intermediate, Taxane Reference Standard, Anticancer Research, Microtubule Inhibitor, GMP-Compliant API, DMSO-Soluble Compound.
