Product Name: Alpha GPC/Choline Alfoscerate
Other name: Alpha GPC, α-GPC, Choline Alfoscerate, L-α GPC, GPC Choline, l-alpha-glycerylphosphorylcholine, Choline Glycerophosphate, CDP-choline, Glycerophosphocholine, Glicerofosfato de Colina, Glycerophosphate De Choline.
Assay:50% ~99%
CAS No.: 28319-77-9
Formula: C8H20NO6P
Mol. Mass: 257.22
Appearance: white to off-white powder or transparent liquid.
Choline Alfoscerate (Alpha-GPC): Comprehensive Product Overview
Introduction
Choline Alfoscerate, also known as Alpha-Glycerophosphocholine (Alpha-GPC), is a naturally occurring phospholipid and a highly bioavailable choline source. Recognized for its ability to cross the blood-brain barrier, it serves as a precursor to acetylcholine, a neurotransmitter critical for cognitive function and memory . This compound is widely used in dietary supplements to support brain health, enhance cognitive performance, and address age-related neurological decline.
Key Benefits
- Cognitive Enhancement
- Memory & Focus: Alpha-GPC improves memory retention, attention, and information processing, making it ideal for students, professionals, and aging populations .
- Neuroprotection: Clinical studies demonstrate its efficacy in slowing cognitive decline in Alzheimer’s disease and vascular dementia .
- Synergistic Effects: When combined with acetylcholinesterase inhibitors (e.g., donepezil), it enhances therapeutic outcomes in dementia patients .
- Physical Performance & Recovery
- Exercise Support: Pre-workout supplementation boosts endurance and reduces fatigue by stimulating growth hormone (hGH) release .
- Anti-Aging & Brain Health
- Neuronal Repair: Reverses age-related structural changes in the hippocampus and frontal cortex, restoring cholinergic neuron function .
- Membrane Fluidity: As a phospholipid, it maintains cell membrane integrity, crucial for neurotransmission .
Target Audiences
- Students: Enhances learning efficiency and exam performance via capsules, gummies, or functional beverages .
- Professionals: Reduces mental fatigue and improves productivity in high-stress environments .
- Athletes: Boosts exercise intensity and recovery in sports drinks or protein powders .
- Aging Adults: Mitigates neurodegenerative symptoms through easy-to-consume formats like softgels or powders .
Product Forms & Usage
- Common Formats: Softgels (400–1,200 mg/dose), tablets, powders, functional beverages, and gummies .
- Bioavailability: Rapid absorption with a short half-life (0.5–6.2 hours), requiring multiple daily doses for sustained effects .
Scientific Backing
- Clinical Trials:Mechanisms: Increases acetylcholine synthesis, restores muscarinic receptors, and enhances nerve growth factor (NGF) signaling .
- In vascular dementia patients, Alpha-GPC significantly improved cognitive scores compared to placebo .
- Outperformed acetyl-L-carnitine (ALCAR) in Alzheimer’s management, with durable benefits .
Safety & Regulatory Status
- GRAS Certification: Recognized as safe by the U.S. FDA since 2012 for use in supplements and functional foods .
- Side Effects: Generally well-tolerated; rare cases of mild gastrointestinal discomfort reported .
Market Leaders
Leading brands include NOW Foods, Jarrow Formulas, and Life Extension, which offer high-purity Alpha-GPC products compliant with global standards .
Conclusion
Choline Alfoscerate (Alpha-GPC) stands out as a versatile supplement backed by robust research, addressing cognitive decline, enhancing physical performance, and supporting overall brain health. Its safety profile and diverse product formulations make it a top choice for consumers seeking evidence-based nootropics.
