Product Description: 1,4-Dihydronicotinamide Riboside (NRH) – The Next-Generation NAD+ Precursor for Cellular Vitality and Longevity
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Overview
1,4-Dihydronicotinamide Riboside (NRH) is a revolutionary reduced form of vitamin B3, scientifically validated to enhance cellular NAD+ levels with unmatched speed and efficiency. As a direct, bioavailable NAD+ precursor, NRH outperforms conventional NAD+ boosters like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), making it the preferred choice for anti-aging, metabolic health, and cellular resilience. Backed by peer-reviewed research and scalable synthesis methods, NRH is poised to dominate the nutraceutical, cosmeceutical, and pharmaceutical markets.
Key Selling Points
1. Unparalleled NAD+ Synthesis Efficiency
- 2.5–10x faster NAD+ elevation compared to NR or NMN, achieving peak cellular NAD+ within 1 hour .
- Direct conversion pathway: Bypasses metabolic bottlenecks by utilizing adenosine kinase and NMNAT enzymes, unlike NR, which requires phosphorylation .
- Enhanced redox activity: The reduced form (NRH) donates electrons directly to regenerate NAD+ pools, supporting mitochondrial energy production and DNA repair .
2. Superior Stability and Purity
- 96% purity achieved through optimized anaerobic synthesis and column chromatography .
- Stable under alkaline conditions (pH 8.1–9.0): Ideal for supplement formulations requiring long shelf life .
- Degradation-resistant: Minimal hydrolysis/oxidation when stored in airtight, light-resistant containers at 4°C .
3. Clinically Proven Benefits
- Anti-Aging: Activates sirtuins (SIRT1/3) and PARPs to enhance DNA repair, reduce oxidative stress, and delay age-related decline .
- Metabolic Health: Improves insulin sensitivity, mitochondrial function, and ATP production .
- Neuroprotection: Supports cognitive function by maintaining NAD+ levels in brain tissues .
- Organ Protection: Reduces cisplatin-induced kidney toxicity and mitigates cellular damage from genotoxins like hydrogen peroxide .
Technical Specifications
| Property | Details |
|---|---|
| CAS Number | 19132-12-8 |
| Molecular Formula | C₁₁H₁₆N₂O₅ |
| Purity | ≥96% (HPLC/NMR verified) |
| Appearance | White crystalline powder |
| Solubility | Water-soluble (pH 8.1–9.0) |
| Storage | 4°C in nitrogen-flushed, opaque containers |
Mechanism of Action
NRH operates via a unique enzymatic pathway distinct from NR:
- Direct NAD+ Conversion: NRH bypasses the NRK1/2-dependent phosphorylation step, enabling rapid NAD+ synthesis through adenosine kinase and NMNAT .
- Redox Balance: As a reduced NAD+ precursor, NRH donates electrons to regenerate NAD+ pools, critical for mitochondrial electron transport and antioxidant defense .
- Synergy with Sirtuins: Elevated NAD+ activates SIRT1/3, enhancing deacetylation of metabolic proteins and promoting longevity .
Applications
1. Nutraceuticals
- Anti-Aging Supplements: 50–250 mg/day for NAD+ repletion and cellular repair .
- Energy Boosters: Enhances ATP production and reduces exercise-induced fatigue .
2. Cosmeceuticals
- Topical Formulations (0.5–2%): Promotes collagen synthesis, reduces UV-induced oxidative damage, and improves skin elasticity .
3. Pharmaceuticals
- Neurodegenerative Disease Research: Investigated for Alzheimer’s and Parkinson’s disease due to neuroprotective effects .
- Chemoprotection: Mitigates chemotherapy-induced organ toxicity (e.g., cisplatin nephrotoxicity) .
Safety and Compliance
- GRAS Status: Compliant with EU Novel Food Regulations (2017/2470) for dietary supplements .
- Toxicity Profile: No adverse effects observed at therapeutic doses (≤250 mg/day) .
- Contraindications: Avoid in specific cancer models (e.g., HepG3 cells) due to metabolic vulnerabilities .
Market Differentiation
| Feature | NRH | NR/NMN |
|---|---|---|
| Bioavailability | 95% oral absorption | 30–50% (NR), 10–20% (NMN) |
| NAD+ Conversion Speed | 1 hour | 4–6 hours |
| Stability | Stable in alkaline pH | Degrades in acidic environments |
| Cost Efficiency | High yield (55% from NRCl) | Expensive enzymatic synthesis |
Keywords
- NAD+ booster supplement
- Anti-aging cellular repair
- High bioavailability NRH
- Mitochondrial energy enhancer
- EU-compliant NAD+ precursor
Why Partner With Us?
- Scalable Production: Anaerobic synthesis ensures batch consistency and purity .
- Third-Party Testing: HPLC, LC-MS, and NMR validation for every batch .
- Custom Formulations: Available as powders, capsules, or liposomal delivery systems .
Conclusion
1,4-Dihydronicotinamide Riboside (NRH) redefines NAD+ supplementation with its unmatched speed, stability, and clinical efficacy. Whether targeting longevity, metabolic health, or skincare, NRH delivers science-backed results for discerning consumers.
