Product name: 4-Butylresorcinol powder
Specification: 98% min
CAS No.: 18979-61-8
English synonyms: N-BUTYLRESEOCINOL；4-N-BUTYLRESORCINOL；4-BUTYLRESORCINOL；4-phenylbutane-1,3-diol；2，4-DIHYDROXY-N-BUTYLBENZEN
Molecular formula: C10H14O2
Molecular weight: 166.22
Melting point: 50~55℃
Boiling point: 166℃/7mmHg(lit.)
Dosage: 0.1-5%
Package: 1kg, 25kg
4-Butylresorcinol Powder: High-Purity Tyrosinase Inhibitor for Cosmetic and Skincare Applications
Product Overview
4-Butylresorcinol (CAS: 18979-61-8), also known as 4-n-Butylresorcinol or Rucinol, is a potent derivative of resorcinol. It is widely recognized for its ability to inhibit tyrosinase, the key enzyme in melanin synthesis, making it a highly effective ingredient for skin brightening and hyperpigmentation treatment . With a molecular formula of C₁₀H₁₄O₂ and molecular weight of 166.22 g/mol, this compound is a stable, small-molecule agent that penetrates skin layers efficiently to deliver visible results .
Key Features
- Superior Efficacy:
- IC50 = 11.27 μM against tyrosinase, outperforming traditional agents like arbutin and kojic acid .
- Clinically proven to reduce UV-induced pigmentation and melasma, with rapid results observed in split-face trials .
- Broad Applications:
- Cosmetics & Skincare: Whitening creams, serums, and anti-aging formulations .
- Pharmaceutical Research: Used in studies targeting melanin-related disorders .
- Cleaning & Personal Care: Incorporated into products requiring mild yet effective depigmenting agents .
- Safety & Stability:
- High Purity: Available in analytical standard grade (≥97.0% GC) and research-grade (99.32% purity) .
- Hypoallergenic: Low risk of irritation, suitable for sensitive skin and even safe during pregnancy under guidance .
Technical Specifications
| Property | Details |
|---|---|
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in organic solvents (e.g., DMSO, methanol); slightly soluble in water |
| Storage | -20°C in airtight containers; stable for 2 years (unopened) |
| Melting Point | ~53°C |
| Safety | GHS Warning: May cause skin/eye irritation. Use PPE during handling . |
Mechanism of Action
4-Butylresorcinol targets both tyrosinase and TRP-1 (tyrosinase-related protein-1), blocking melanin production at multiple stages . Its antioxidant properties further protect skin from oxidative stress, enhancing overall radiance .
Why Choose Our Product?
- Certified Quality: Compliant with international standards (NMR spectrum available via ChemisTwin® for identity confirmation) .
- Customizable Formats: Offered in 50 mg to 500 mg quantities, with DMSO solutions for research convenience .
- Global Shipping: Non-hazardous transport classification (UN3077, Packing Group III) ensures safe delivery .
Recommended Use
- Skincare Formulations: Add 0.1–0.3% concentration to creams or serums for hyperpigmentation treatment .
- Research Applications: Use as a reference standard in melanogenesis studies .
References
- Huh, S. et al. (2010). Annals of Dermatology .
- Kolbe, L. et al. (2012). Journal of the European Academy of Dermatology .
- Safety Data Sheet (AK Scientific, Inc.) .
Keywords include “tyrosinase inhibitor,” “skin whitening agent,” “4-n-Butylresorcinol,” and “CAS 18979-61-8,” aligned with common search terms in the cosmetic and pharmaceutical industries.
