4-Butylresorcinol Powder

Product name: 4-Butylresorcinol powder

Specification: 98% min

CAS No.: 18979-61-8

English synonyms: N-BUTYLRESEOCINOL；4-N-BUTYLRESORCINOL；4-BUTYLRESORCINOL；4-phenylbutane-1,3-diol；2，4-DIHYDROXY-N-BUTYLBENZEN

Molecular formula: C₁₀H₁₄O₂

Molecular weight: 166.22

Melting point: 50~55℃

Boiling point: 166℃/7mmHg(lit.)

Dosage: 0.1-5%

Package: 1kg, 25kg

4-Butylresorcinol: Potent Tyrosinase Inhibitor for Skin Whitening & Cosmetics

Product Overview
4-Butylresorcinol (CAS: 18979-61-8), also known as Rucinol or 4-n-Butylresorcinol, is a stable derivative of resorcinol with the molecular formula C₁₀H₁₄O₂ and a molecular weight of 166.22 g/mol . It is a white to light-beige crystalline powder, soluble in organic solvents like DMSO and methanol but slightly insoluble in water .

Mechanism of Action
As a potent tyrosinase inhibitor (IC₅₀: 11.27–21 μM), 4-Butylresorcinol targets both tyrosinase and TRP-1 enzymes, which are critical in melanin synthesis . By blocking these enzymes, it effectively reduces UV-induced pigmentation, age spots, and melasma, promoting an even skin tone . Its small molecular size allows deep skin penetration, ensuring rapid and uniform brightening effects .

Key Applications

• Cosmetics & Skincare: Widely used in serums, creams, and lotions for hyperpigmentation treatment and skin-lightening .
• Clinical Efficacy: Clinical trials demonstrate superior performance over hydroquinone and arbutin, with significant improvement in melasma within weeks .
• Synergistic Use: Enhances efficacy when combined with vitamin C, offering a dual-action approach against pigmentation .

Product Advantages

• High Safety Profile: Hypoallergenic and suitable for sensitive skin, with minimal irritation reported .
• Stability & Purity: Available in ≥97% purity (GC-grade) with a shelf life of 2 years when stored at -20°C in airtight conditions .
• Versatility: Compatible with formulations for cleaning products, food, and beverages, though primarily optimized for topical use .

Technical Specifications

• CAS No.: 18979-61-8
• Synonyms: Rucinol, 4-Butyl-1,3-benzenediol
• Storage: Powder at -20°C; DMSO solutions stable for 1 month at -20°C .
• Solubility: 150 mg/mL in DMSO .

Safety & Handling

• Precautions: May cause mild skin/eye irritation. Use PPE (gloves, goggles) during handling .
• Regulatory Compliance: Complies with EU cosmetic regulations; not classified as hazardous under standard transport guidelines .

References

1. Huh et al. (2010) demonstrated rapid melasma improvement in split-face trials .
2. Kolbe et al. (2012) confirmed its tyrosinase inhibition efficacy in hyperpigmentation models .
3. Shamanna et al. (2016) highlighted safety in multicentric studies .

Keywords: Tyrosinase inhibitor, skin whitening, 4-Butylresorcinol, melasma treatment, Rucinol, cosmetic ingredient, depigmenting agent.