5-Aminolevulinic acid Phosphate(ALA)

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  • 5-Aminolevulinic acid Phosphate(ALA)

Short Description:

What is 5-ALA？

The 5-ALA is a preconjugated compound of tetrahydropyrrole (which is the substance that constitutes heme, cytochrome, and vitamin B12). The natural amino acids of 5-amino acetylpropionic acid (5-ALA) have a blocking effect on Coronavirus! Coronavirus can be killed in the human body when 5-ALA amino acids are up to a certain concentration.


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
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    Product Detail

    Product Tags

    Product Name:5-aminolevulinic acid Phosphate

    Synonym:5-ALA

    CAS No: 868074-65-1

    Purity:≧98.0%

    Color:Light yellow to white powder

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    5-Aminolevulinic Acid Phosphate (ALA) Product Description

    Product Overview

    5-Aminolevulinic Acid Phosphate (5-ALA phosphate) is a naturally occurring amino acid derivative, widely recognized for its pivotal role in biological processes such as heme and chlorophyll biosynthesis . With the CAS number 868074-65-1, it appears as a white to off-white crystalline powder and is available in food-grade (95% purity) and pharmaceutical-grade (98% purity) formulations . Its molecular formula is C5H12NO7P (molecular weight: 229.125), and it exhibits high solubility in water (50 mg/mL) .

    Key Applications

    1. Medical & Therapeutic Uses
      • Photodynamic Therapy (PDT): ALA is a pro-drug converted into protoporphyrin IX (PpIX), a photosensitizer used to target and destroy cancer cells under specific light wavelengths. It is FDA-approved for glioma resection and skin cancer treatment .
      • Atherosclerosis Management: Studies show ALA-mediated sonodynamic therapy reduces plaque formation by enhancing macrophage activity .
      • Diagnostic Imaging: ALA-induced fluorescence aids in precise tumor localization during surgery .
    2. Agricultural Applications
      • As a plant growth regulator, ALA enhances photosynthesis, respiration, and stress tolerance, improving crop yield and quality .
    3. Cosmetic Industry
      • ALA-containing formulations improve skin hydration and reduce wrinkles, with clinical trials demonstrating efficacy at low doses (e.g., 31 ng/day) .

    Safety & Pharmacokinetics

    • Safety Profile: Low-dose ALA phosphate is well-tolerated. Oral bioavailability reaches 100%, with 34% excreted unchanged in urine within 12 hours . Preclinical studies confirm no significant toxicity at recommended doses .
    • Caution: Excessive ALA may induce oxidative stress in rare cases (e.g., porphyria), but controlled usage minimizes risks .

    Production & Quality

    • Advanced Synthesis: Engineered E. coli strains (e.g., PIECE) optimize ALA production via metabolic flux redirection, achieving yields up to 8.21 g/L .
    • Strict Standards: Our product complies with GMP guidelines, ensuring consistency for pharmaceutical and food applications .

    Packaging & Storage

    • Packaging: Available in 25 kg/drum (industrial) or 1 kg/bag (research use) .
    • Storage: Store in sealed, light-protected containers at 2–8°C to maintain stability for up to 2 years .

    Why Choose Our ALA Phosphate?

    • Multifunctional: Versatile applications in medicine, agriculture, and cosmetics.
    • High Purity: Rigorous QC ensures ≥95% (food) and ≥98% (pharma) purity.
    • Research-Backed: Supported by clinical trials and metabolic studies .

    Keywords: 5-ALA phosphate, heme biosynthesis, photodynamic therapy, plant growth regulator, CAS 868074-65-1

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