Product Name:7,8-Dihydroxyflavone

CAS No:38183-03-87

Other Name:7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;

DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;

7,8-dihydroxy-2-phenyl-1-benzopyran-4-one,,8-Dihydroxyflavone (7,8-DHF)

Specifications: 98.0%

Colour: Yellow powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Product Description: 7,8-Dihydroxyflavone (7,8-DHF) – A Multifaceted Compound for Neuroprotection and Cognitive Enhancement

Overview
7,8-Dihydroxyflavone (7,8-DHF), a naturally occurring flavonoid found in plants such as Tridax procumbens and Godmania aesculifolia, is a versatile bioactive compound with dual mechanisms of action. It acts as a selective TrkB receptor agonist (mimicking brain-derived neurotrophic factor, BDNF) and a competitive inhibitor of pyridoxal phosphatase (PDXP). These properties make it a promising candidate for neurological research, cognitive enhancement, and therapeutic applications.

Key Features

1. Molecular Profile
   • Chemical Formula: C₁₅H₁₀O₄
   • CAS Number: 38183-03-8
   • Molecular Weight: 254.24 g/mol
   • Purity: ≥98% (HPLC verified)
   • Solubility:

• Highly soluble in DMSO (up to 100 mM) and ethanol (25 mM)
• Sparingly soluble in water (<1 mg/mL).

2. Storage & Handling
   • Powder: Store at -20°C in a desiccated environment (stable for 3 years).
   • Solutions: Aliquot and store at -80°C (stable for 1–2 years).
   • Safety Precautions:

• Use protective gloves, goggles, and lab coats.
• Avoid inhalation, ingestion, or direct skin contact.
• Follow GHS hazard classifications (acute toxicity, eye/skin irritation).

Mechanisms of Action

1. TrkB Receptor Agonism
   • Binds to TrkB with high affinity (Kd ≈ 320 nM), activating downstream pathways (PI3K/Akt, MAPK) to promote:

• Neurogenesis and synaptic plasticity.
• Neuroprotection against oxidative stress, excitotoxicity, and apoptosis.
• Cognitive enhancement in models of Alzheimer’s disease, traumatic brain injury, and depression.

2. PDXP Inhibition
   • Competitively inhibits pyridoxal phosphatase (PDXP), increasing pyridoxal 5’-phosphate (PLP), the active form of vitamin B5.
   • Benefits:

• Reverses age-dependent PLP decline in the hippocampus.
• Improves learning and memory in preclinical models.

3. Additional Effects
   • Antioxidant Activity: Suppresses JNK/NF-κB pathways to reduce inflammation.
   • Metabolic Regulation: Enhances glucose uptake and lowers blood glucose levels.

Applications

1. Neurological Research
   • Study neuroprotection in Alzheimer’s, Parkinson’s, and ischemic stroke models.
   • Investigate BDNF/TrkB signaling in synaptic plasticity and mood disorders.
2. Cognitive Health Supplements
   • Potential use in nootropics for memory enhancement and neuroplasticity.
3. Therapeutic Development
   • Explore dual-target strategies (TrkB + PDXP) for vitamin B6 deficiency-related cognitive decline.

Safety & Dosage

• Toxicity: Preclinical studies show no significant toxicity at therapeutic doses.
• Recommended Dosage (research use only):
  • In vitro: 250 nM–10 µM.
  • In vivo (mice): 50–100 mg/kg/day orally or via intraperitoneal injection.

Why Choose 7,8-DHF?

• Dual-Action Profile: Combines TrkB activation and PDXP inhibition for multifaceted benefits.
• Blood-Brain Barrier Penetration: Effective in central nervous system targeting.
• Research-Backed: Validated in over 50 preclinical studies for neuroprotection, cognitive enhancement, and metabolic regulation.

 Keywords: TrkB agonist, PDXP inhibitor, neuroprotective agent, cognitive enhancer, flavonoid benefits, 7,8-DHF solubility, Alzheimer’s research, BDNF mimic.