Product Name:Acetyl zingerone
Other Name:2,4-Pentanedione,3-vanillyl3-Vanillyl-2,4-pentanedione
3-(4-hydroxy-3-methoxybenzyl)pentane-2,4-dione
2,4-Pentanedione, 3-((4-hydroxy-3-methoxyphenyl)methyl)-
3-(3′-Methoxy-4′-hydroxybenzyl)-2,4-pentandion [German]
3-(3′-Methoxy-4′-hydroxybenzyl)-2,4-pentandion
CAS No:30881-23-3
Specifications: 98.0%
Colour:White powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Zingerone is one of the antioxidant components of ginger that has been studied for various properties in both mice and humans. Ancient experiments on eastern medicine noted that roasted ginger is better in alleviating various symptoms. Interestingly, it was found that fresh ginger contains high amounts of a compound called Gingerone, which converts to Zingerone on drying or cooking. Gingerone and Zingerone both share the same structure with Curcumin (the active ingredient in Turmeric), giving them similar pharmacologic effects. Acetyl Zingerone has an added acetyl group (methyl group single-bonded to a carbonyl), which confers additional scavenging, chelating, and stabilizing potential to Zingerone. AZ is intentionally engineered to neutralize key Radical Oxygen species (ROS), Non-radical Oxygen species (singlet oxygen), and strong nucleophiles (peroxynitrite) that are induced by UVR
Acetyl Zingerone: A Multi-Targeted Anti-Aging Ingredient for Comprehensive Skin Protection
Product Overview
Acetyl Zingerone is an innovative, photostable skincare ingredient designed to combat intrinsic and extrinsic signs of aging. Inspired by the molecular structures of turmeric and ginger, it offers 24/7 protection against UV-induced damage, oxidative stress, and DNA degradation while promoting skin repair and resilience . Clinically proven to reduce wrinkles, pigmentation, and erythema, it is compatible with all skin types, including sensitive and acne-prone skin .
Key Benefits
- Multi-Mechanism Antioxidant & Anti-Inflammatory Action
- ROS Neutralization: Directly scavenges free radicals (e.g., hydroxyl, peroxyl) and quenches singlet oxygen, outperforming vitamin E in lipid peroxidation inhibition (IC50: 0.48 µg/mL vs. 36.3 µg/mL) .
- Selective Chelation: Binds Fe²⁺/Cu²⁺ ions to prevent hydroxyl radical formation, reducing oxidative damage .
- Inflammation Control: Suppresses IL-17A target genes and iNOS activity, reducing erythema and edema .
- DNA Damage Prevention & Photostability
- Continuous CPD Inhibition: Blocks cyclobutane pyrimidine dimer (CPD) formation even after sun exposure, mitigating melanoma risks .
- Superior Light Stability: Retains efficacy under UV/blue light, unlike curcumin, ensuring long-lasting protection .
- ECM Reinforcement & Collagen Synthesis
- MMP Inhibition: Downregulates MMP-1, MMP-3, and MMP-12 (key collagen-degrading enzymes) while stimulating collagen I, III, and IV production by up to 84% .
- TIMP-2 Activation: Enhances natural MMP regulation for balanced extracellular matrix remodeling .
- Clinical Results
- 8-Week Efficacy: 25.7% reduction in wrinkle severity, 30.1% decrease in wrinkle volume, and 25.6% improvement in skin tone .
- Microbiome Balance: Maintains microbial diversity, strengthening skin barrier function .
Technical Specifications
- INCI Name: Acetyl Zingerone
- CAS No.: 30881-23-3
- Molecular Formula: C₁₃H₁₆O₄
- Molecular Weight: 236.26 g/mol
- Recommended Usage: 0.5–1% in anti-aging formulations; 0.1–0.2% as a chelator
- Solubility: >20% in dimethyl isosorbide, ethoxydiglycol, and dipropylene glycol
- Storage: -20°C (powder, 3 years); -80°C (solvent)
Applications
- Anti-Aging Serums: Reduces wrinkles and improves elasticity.
- Sunscreens & Post-Sun Care: Enhances UV protection and repairs photo-damage.
- Daily Moisturizers: Combats pollution and blue light-induced ROS.
- Brightening Products: Addresses hyperpigmentation via melanogenesis inhibition .
Why Choose Acetyl Zingerone?
- REACH Registered: Compliant with EU safety standards for cosmetic use .
- Synergistic Formulations: Pairs effectively with hexylresorcinol for hyperpigmentation control .
- Non-Sensitizing: No reported irritation or preservatives, ideal for sensitive skin
