Agaricus Blazei Extract (Polysaccharides 10%-50% by UV & Beta Glucan 10%-30% by UV): Comprehensive Product Profile

1. Product Overview

INCI Name: Agaricus Blazei (Mushroom) Extract
Standardization:

• Polysaccharides: 10%-50% by UV Spectrophotometry
• Beta Glucan: 10%-30% by UV Spectrophotometry
  Appearance: Light brown to amber powder/liquid
  Solubility: Water-soluble, compatible with glycols and glycerin
  Certifications: ISO 9001, Halal, Kosher, Non-GMO

Target Markets:

• Cosmetics: Anti-aging creams, serums, sunscreens 
• Nutraceuticals: Immune-boosting supplements
• Pharmaceuticals: Antiviral formulations 

2. Key Bioactive Components & Mechanisms

2.1 Polysaccharides (10%-50% UV Standardized)

• Function:
  • Immune Modulation: Activates macrophages and NK cells via β-glucan receptor binding
  • Antioxidant Activity: Scavenges free radicals (DPPH assay, EC50 5692.31 μg/mL) , reduces oxidative stress-induced skin aging
  • Skin Hydration: Enhances hyaluronic acid synthesis, improves moisture retention

2.2 Beta Glucan (10%-30% UV Standardized)

• Function:
  • Wound Healing: Stimulates collagen synthesis (collagenase inhibition shown in vitro)
  • UV Protection: Strengthens skin barrier against UV-induced damage
  • Anti-inflammatory: Reduces cytokine production (IL-6, TNF-α) in clinical models

3. Proven Efficacy & Applications

3.1 Cosmetic Applications

• Anti-Aging:
  • Collagen Enhancement: Reduces wrinkle depth by 42% in 12-week trials (UV spectrophotometry at 517nm)
  • Elasticity Improvement: 75% increase in skin firmness with 30% polysaccharide formulations
• Sun Care:
  • SPF Booster: Synergizes with zinc oxide for broad-spectrum UV protection

3.2 Nutraceutical Applications

• Immune Support:
  • Antiviral Activity: Inhibits RSV replication (SI = 10.85 for aqueous extract)
  • Adaptogenic Effect: Reduces fatigue biomarkers in clinical studies

3.3 Pharmaceutical Potential

• Antiviral Formulations: Potential alternative to ribavirin for RSV treatment (EC50 = 4433.28 μg/mL) 
• Adjuvant Therapy: Enhances efficacy of chemotherapy drugs via immunomodulation

4. Quality Assurance & Technical Specifications

4.1 UV Standardization Process

• Method: UV-Vis spectrophotometry at 500nm for polysaccharides, validated per ICH guidelines 
• Batch Consistency: ±2% variance in polysaccharide content

4.2 Safety Profile

• Non-toxic: CC50 > 4433 μg/mL in cytotoxicity tests 
• Compliance: EU Cosmetic Regulation (EC) No 1223/2009, FDA GRAS status 

5. Usage Guidelines

5.1 Cosmetic Formulations

• Recommended Dosage:
  • Serums/Creams: 1%-5% (Polysaccharides 10%-30%)
  • Masks: 2%-8% (Beta Glucan 10%-20%)
• Synergistic Combinations:
  • With Glycolic Acid: Enhances exfoliation and collagen synthesis
  • With Hyaluronic Acid: Boosts hydration and elasticity

6. Global Market Insights

• Top Importers: United States (33,360 transactions), Uzbekistan (12,873 transactions) 
• Leading Brands: Excel Herbal Industries (Malaysia), Sunny Care (Peru) 
• Trends: 87% YoY growth in nutraceutical applications (2024 data) 

7. Frequently Asked Questions (FAQs)

Q: Can this extract be used in sensitive skin formulations?
A: Yes. The extract has a high safety profile (CC50 > 4433 μg/mL) and is suitable for sensitive skin when used at ≤3% concentration. Always conduct patch testing. 

Q: How does UV standardization ensure product quality?
A: UV spectrophotometry quantifies bioactive polysaccharides and beta glucans, ensuring batch-to-batch consistency and efficacy. 

8. Why Choose Us?

• End-to-End Compliance: Full documentation for EU/US market entry 
• Customization: Adjust polysaccharide/beta glucan ratios per application needs
• Sustainability: Ethically wildcrafted in Brazil, carbon-neutral production

References Embedded:

• Anti-aging data from DPPH assays 
• Antiviral efficacy against RSV 
• UV standardization methods 
• Cosmetic safety assessments
• Keywords: Agaricus Blazei Mushroom Extract, Beta Glucan UV Standardized, Polysaccharides for Immunity, Anti-aging Skincare, Antiviral Applications