Aniracetam: Cognitive Enhancer for Brain Health and Research
Product Overview
Aniracetam is a nootropic compound belonging to the racetam class, originally developed in the 1970s for cognitive enhancement. It is widely used to support memory, learning, and neuroprotection, with emerging research suggesting potential benefits in Alzheimer’s disease (AD) prevention by reducing amyloid-beta (Aβ) plaque accumulation . Available as capsules or powder, it is formulated for research and dietary supplementation (not FDA-approved for medical use in the U.S.) .
Key Features
- Mechanism of Action
- AMPA Receptor Modulation: Enhances synaptic plasticity by slowing AMPA receptor desensitization, improving excitatory neurotransmission .
- BDNF Activation: Increases brain-derived neurotrophic factor (BDNF), promoting neurogenesis and synaptogenesis .
- Neuroprotection: Reduces oxidative stress and inflammation linked to Aβ toxicity, potentially delaying AD progression .
- Indications
- Cognitive enhancement in healthy individuals (memory, focus, learning).
- Research applications for neurodegenerative diseases (e.g., Alzheimer’s, dementia) .
- Mood support (anxiety reduction, emotional well-being) .
Product Specifications
- CAS No.: 72432-10-1 | Purity: ≥98% (HPLC)
- Molecular Formula: C₁₂H₁₃NO₃ | Molecular Weight: 219.24 g/mol
- Form: White crystalline powder or capsules.
- Storage: -20°C in airtight containers; stable for ≥5 years .
Available Sizes
- 1g: 618.00∣5g:2136.00 (pre-order) .
Usage Guidelines
- Dosage: 500–1500 mg/day, divided into 2–3 doses. Take with fatty foods (e.g., olive oil) to enhance bioavailability .
- Duration: Effects onset within 10–30 minutes, lasting 4–6 hours .
- Combination Therapy: Pair with cholinergics (e.g., Alpha-GPC) to optimize cognitive effects .
Safety & Side Effects
- Common Side Effects: Mild anxiety, insomnia, headache, or gastrointestinal discomfort. Most symptoms resolve with continued use .
- Contraindications: Avoid during pregnancy or lactation (suspected reproductive toxicity) .
- Precautions: Consult a healthcare provider before use, especially with pre-existing conditions or medications .
Research Highlights
- Alzheimer’s Disease: Aniracetam may reduce Aβ production by upregulating α-secretase activity via BDNF and mGluR pathways .
- Clinical Trials: Demonstrated safety and tolerability in elderly populations over 6-month periods .
Regulatory & Compliance
- Intended Use: For research purposes only. Not for human consumption or diagnostic/therapeutic applications .
- Legal Status: Available as a dietary supplement in the U.S.; prescription-only in Europe .
References
- Mizuki et al., 1984: Efficacy in senile dementia .
- Cumin et al., 1982: Cognitive improvement in rodent models .
- Love, 2024: Aβ reduction and neuroprotection .