Product Name:Celastrol Powder
CAS NO.34157-83-0
Botanical Source:The God Vine(Tripterygium wilfordii hook.f)
Specification:98% HPLC
Appearance: Reddish orange crystal powder
Origin: China
Benefits: Anti-inflammatory, antioxidant, anti-cancer
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Celastrol Powder | Natural Anti-Inflammatory Supplement | 98% Purity Lab-Tested
Harness the Power of Traditional Herbal Extract for Modern Health Support
What is Celastrol Powder?
Celastrol is a bioactive compound derived from the root of Tripterygium wilfordii (Thunder God Vine), a plant used in traditional Chinese medicine for centuries. Modern scientific studies, including research published in Nature and PubMed, highlight its potential to support cellular health, metabolic function, and inflammatory response management.
Celastrol Powder: A Multifaceted Proteasome Inhibitor for Research Applications
Product Overview
Celastrol (CAS: 34157-83-0), a bioactive triterpene derived from Tripterygium wilfordii (Thunder God Vine), is a potent proteasome inhibitor with extensive pharmacological properties, including anti-cancer, anti-inflammatory, and neuroprotective effects . With a molecular formula of C₂₉H₃₈O₄ and molecular weight of 450.61 g/mol, it is widely utilized in preclinical research to study mechanisms of disease and therapeutic interventions .
Key Features
- Proteasome Inhibition: Selectively inhibits the chymotrypsin-like activity of the 20S proteasome (IC₅₀ = 2.5 μM), promoting the accumulation of misfolded proteins and inducing apoptosis in cancer cells .
- Anti-Cancer Activity:
- Suppresses tumor growth in prostate (PC-3), breast, and melanoma models by inhibiting NF-κB, AKT/mTOR pathways, and angiogenesis .
- Enhances TRAIL-induced apoptosis and reduces metastasis by downregulating MMP-2/9 .
- Anti-Inflammatory & Immunomodulatory Effects:
- Reduces pro-inflammatory cytokines (TNF-α, IL-1β) and chemokines (MCP-1, RANTES) in rheumatoid arthritis and neuritis models .
- Shifts macrophage polarization from M1 (pro-inflammatory) to M2 (anti-inflammatory) phenotypes .
- Metabolic Regulation:
- Reverses insulin resistance and obesity via hypothalamic leptin signaling, independent of UCP1 .
- Neuroprotection:
- Inhibits Aβ aggregation and tau hyperphosphorylation, showing potential in Alzheimer’s and Parkinson’s disease models .
Applications
- Cancer Research: Study mechanisms of apoptosis, metastasis, and drug resistance in prostate, breast, and oral squamous cell carcinomas .
- Inflammatory Diseases: Investigate therapeutic strategies for rheumatoid arthritis, autoimmune neuritis, and inflammatory bowel disease .
- Metabolic Disorders: Explore anti-obesity and anti-diabetic effects in preclinical models .
- Neurodegenerative Diseases: Assess neuroprotection in Alzheimer’s, Parkinson’s, and ischemic stroke models .
Product Specifications
- Purity: ≥99% (HPLC-validated) .
- Solubility:
- ≥22.55 mg/mL in DMSO; insoluble in H₂O and ethanol .
- For in vitro use: Prepare stock solutions in DMSO (e.g., 10 mM) and dilute in culture medium (final DMSO <0.5%) .
- Storage: -20°C in dark, stable for 3 years .
- Prostate Cancer: Celastrol inhibits PC-3 xenograft growth in nude mice by 70% (2 μM dose) .
- Arthritis: Reduces joint inflammation by 50% in murine models via chemokine suppression (200 μg/day) .
- Bioavailability: Oral bioavailability is ~17%, suggesting optimization for in vivo delivery .
Usage Guidelines
- Reconstitution: Dissolve in DMSO for stock solutions (e.g., 10 mM). Avoid aqueous buffers .
- Working Concentration: Use 0.01–10 μM for in vitro studies; 1–4 mg/kg for in vivo models .
- Safety: Handle with gloves; cytotoxic at high doses (e.g., IC₅₀ = 2 μM in DU145 cells)
