Citicoline Sodium Bulk Powder

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  • Citicoline Sodium Bulk Powder

Short Description:

CITICOLINE belongs to a group of medications called ‘psychostimulants’ used to treat stroke, head trauma or injury, Alzheimer’s disease, Parkinson’s disease, and glaucoma. A stroke occurs due to insufficient blood supply to the brain. Alzheimer’s disease is a progressive age-related memory loss.

Citicoline (CDP-choline or cytidine 5′-diphosphocholine) is an endogenous nootropic compound that occurs in the body naturally. It is a critical intermediate in synthesizing phospholipids in the cell membrane. Citicoline plays several significant roles in human physiology, such as improvement of structural integrity and signal conduction for cell membranes, and synthesis of phosphatidylcholine and acetylcholine.

Citicoline is commonly referred to as a “brain nutrient.” It is taken orally and converts to choline and cytidine, the latter of which turns into uridine in the body. Both of them protect brain health and help promote learning behaviors.


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
  • E-mail:: info@trbextract.com
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    Product Detail

    Product Tags

    Product Name:Citicoline Sodium powder

    CAS NO.:33818-15-4

    Specification:99%

    Appearance: Fine white to off-white crystal Powder

    Origin: China

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    Citicoline Sodium Bulk Powder: High-Purity Neuroprotective Agent for Cognitive & Ocular Health

    Product Overview

    Citicoline Sodium (CAS 33818-15-4), also known as CDP-Choline sodium, is a naturally occurring endogenous compound critical for phospholipid synthesis in cellular membranes. With a molecular formula of C₁₄H₂₅N₄NaO₁₁P₂ and molecular weight 510.31, this white crystalline powder is highly soluble in water (200 mg/mL) and meets USP 41 standards for purity (98.0%-102.0%) . Sourced from premium manufacturers like Kyowa Hakko Bio, it is widely utilized in pharmaceuticals, dietary supplements, and ophthalmic solutions .

    Key Benefits & Applications

    1. Neuroprotection & Cognitive Enhancement
      • Mechanism: Citicoline Sodium hydrolyzes into cytidine and choline, precursors for phosphatidylcholine synthesis—essential for neuronal membrane repair and neurotransmitter regulation .
      • Clinical Applications:
    • Cognitive Decline: Shown to improve memory, focus, and learning in Alzheimer’s and dementia models .
    • Stroke & Brain Injury: Enhances post-stroke recovery by reducing oxidative stress and promoting neural repair .
    • Traumatic Brain Injury (TBI): While some trials indicate no significant improvement in severe TBI, it remains approved in 59 countries for TBI support due to its neurorepair potential .
    1. Ocular Health
      • Glaucoma & AMD: Topical 2% citicoline ophthalmic solutions (e.g., OMK1®-LF) improve visual acuity and optic nerve function, with vitreous concentrations reaching 406.72 μg/mL in clinical studies .
      • Retinal Protection: Reduces oxidative damage in age-related macular degeneration (AMD) .
    2. Industrial & Cosmetic Uses
      • Skincare: Enhances skin hydration and elasticity in creams/lotions .
      • Supplements: Available in capsules (250-1000 mg), tablets, and oral solutions (500 mg/day) for cognitive support .

    Product Specifications

    • Purity: ≥98% (HPLC-verified) .
    • Storage:
      • Powder: Stable for 3 years at -20°C.
      • Solutions: Store at -80°C for 1 year.
    • Packaging: 25 mg, 100 mg, 200 mg bulk powder options; customizable OEM solutions .
    • Safety: Well-tolerated with minimal side effects; contraindicated in shellfish allergy patients .

    Quality Assurance

    • Analytical Methods: Validated HPLC using C18 columns (L1 filler) with UV detection (262 nm), ensuring compliance with USP and EMA standards .
    • Certifications: Listed in WHO ATC, FDA Unique Ingredient Identifier (536BQ2JVC7), and EU Novel Food approvals (2014/423/EU) .

    Why Choose Our Citicoline Sodium?

    • Global Compliance: Meets USP, EP, and ICH guidelines for pharmaceutical use.
    • Bulk Supply: Annual production capacity of 200 tons, ensuring scalable and cost-effective solutions .
    • Research-Backed: Supported by 50+ clinical studies on neuroprotection and ocular efficacy .

    Contact Us Today
    For pricing, COA, or custom formulations, reach out to our team. Elevate your product line with Citicoline Sodium—trusted by leading pharmaceutical and nutraceutical brands worldwide.

    Keywords: Citicoline Sodium bulk powder, CDP-Choline supplier, neuroprotective agent, cognitive enhancer, ocular health supplement, USP-certified nootropic.

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