Citicoline Sodium Powder

Short Description:

Citicoline (CDP-choline or cytidine 5′-diphosphocholine) is an endogenous nootropic compound that occurs in the body naturally. It is a critical intermediate in synthesizing phospholipids in the cell membrane.Citicoline is commonly referred to as a “brain nutrient.” It is taken orally and converts to choline and cytidine, the latter of which turns into uridine in the body.Citicoline Sodium was originally a nutritional supplement rich in choline and cytosine with neuroprotective activity. Citicoline Sodium, also known as cytidine-5-bisphosphocholine or CDP-choline, is hydrolyzed in the intestine into cytidine and choline. Citicoline Sodium is found in all animal and plant cell membranes and occurs naturally in small amounts in some foods. Sodium helps improve memory, brain function, and mood because it supports brain cell synthesis, brain energy, and concentration. Citicoline Sodium is produced endogenously as an intermediate in the production of phosphatidylcholine from choline and is then hydrolyzed in the small intestine, making choline and cytidine available for further biosynthesis. is a compound that helps increase blood flow and neurotransmitter levels in the brain. It can help protect and enhance brain function in areas such as cognition, attention and memory by increasing the synthesis and release of phosphatidylcholine in brain cells.

FOB Price: US 5 - 2000 / KG

Min.Order Quantity: 1 KG

Supply Ability: 10000 KG/per Month

Port: Shanghai /Beijing

Payment Terms: L/C,D/A,D/P,T/T,O/A

Shipping Terms: By sea/By Air/By Courier

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Product Detail

Product Tags

Product Name:Citicoline Sodium Bulk Powder

Other Names:citicoline sodium; Cytidine 5′-diphosphocholine sodium salt; CDP-choline sodium salt

CAS NO.:33818-15-4

Specification:90.0% Granule or 98.0% White powder

Molecular Weight: 510.31

Molecular Formula: C14H25N4NaO11P2
Appearance:White crystalline powder
Particle Size: 100% pass 80 mesh

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Citicoline Sodium Powder: Enhance Cognitive Function & Neuroprotection

Product Overview
Citicoline Sodium Powder (CAS No. 33818-15-4) is a high-purity, water-soluble compound renowned for its neuroprotective and cognitive-enhancing properties. As a sodium salt of citicoline (CDP-choline), it serves as a critical intermediate in phosphatidylcholine synthesis, essential for maintaining cellular membrane integrity and neuronal function . With a molecular formula of C₁₄H₂₅N₄NaO₁₁P₂ and a molecular weight of 510.31, this white crystalline powder is widely utilized in dietary supplements, pharmaceuticals, and cosmetic formulations .

Key Features

Neuroprotective Effects:
- Supports recovery from traumatic brain injury (TBI) and ischemic stroke by reducing neuronal damage and enhancing phospholipid metabolism .
- Improves cognitive functions such as memory, attention, and learning in individuals with age-related decline or neurodegenerative conditions (e.g., Alzheimer’s disease) .
High Bioavailability:
- Rapidly absorbed orally with near-complete bioavailability, efficiently crossing the blood-brain barrier to exert central nervous system (CNS) effects .
Dual Applications:
- Brain Health: Enhances brain energy metabolism and acetylcholine synthesis, crucial for neurotransmission .
- Ocular Benefits: Improves visual acuity and optic nerve function, particularly in glaucoma and age-related macular degeneration (AMD) .
Safety & Stability:
- Well-tolerated in long-term use with minimal adverse effects (e.g., mild headache or gastrointestinal discomfort) .
- Stable under recommended storage conditions (-20°C for powder, -80°C for solutions) .

Applications

Dietary Supplements: Ideal for formulations targeting cognitive enhancement, mood regulation, and brain energy support .
Pharmaceuticals: Used in treating stroke, TBI, dementia, and glaucoma. Clinical studies support its role in post-stroke recovery and neurorepair .
Cosmetics: Enhances skin hydration and elasticity in topical products due to phospholipid-regulating properties .

Product Specifications

Parameter	Details
Purity	≥98% (HPLC-verified)
Appearance	White to off-white crystalline powder
Solubility	200 mg/mL in water (ultrasonic treatment recommended)
Storage	-20°C (powder, 3 years); -80°C (solutions, 1 year)
Packaging	25 mg, 100 mg, 200 mg; customizable bulk quantities

Clinical Evidence & Compliance

COBRIT Trial: While citicoline did not show significant improvement in TBI outcomes, it remains effective for stroke and cognitive decline .
Regulatory Approvals: Complies with USP 41 standards, FDA regulations, and international pharmacopeias (e.g., EMA, WHO) .
Manufacturing: Produced under GMP-certified conditions with scalable annual capacity (200+ tons), ensuring consistent quality .

Why Choose Our Citicoline Sodium Powder?

Certified Quality: Rigorous HPLC and stability testing for batch-to-batch consistency .
Custom Solutions: Available in multiple formulations (capsules, oral solutions, injectables) to meet diverse needs .
Global Compliance: Meets HTS, SITC, and ISO standards for seamless international distribution .

Ordering Information
Contact us for certificates of analysis (COA), MSDS, and bulk pricing. No minimum order quantity (MOQ) required .

References