CMS121

CMS121 Featured Image
  • CMS121

Short Description:

CMS121, a synthesized variant of fisetin, a chemical found in fruits and vegetables, improved memory, and slows neurodegeneration in mouse models of Alzheimer’s disease.

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol is a compound also called CMS121. The compound’s structural complexity suggests it may have unique properties and potential uses. To understand its importance, it helps to identify the functional groups present and analyze their potential impact

CMS121 is a substituted quin oline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay. CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively. It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-α, caspase-1, and inducible nit ric oxi de synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol is a compound also called CMS121. The compound’s structural complexity suggests it may have unique properties and potential uses. To understand its importance, it helps to identify the functional groups present and analyze their potential impact. The presence of the quinoline ring suggests that the compound may be biologically active. Quinoline-derived molecules are known for their diverse biological properties, including antibacterial and anti-inflammatory activities. Attachment of the cyclopentyloxy group may contribute to the solubility of the compound or enhance its biological activity through steric effects. In studies on HT22 cells, CMS-121 has demonstrated significant neuroprotective effects, effectively protecting these cells from ischemia and oxidative damage. Furthermore, CMS-121 has significant anti-inflammatory properties, indicating its ability to modulate inflammatory responses. By doing so, CMS-121 has the potential to reduce inflammation in various tissues and organs.  CMS-121 has strong pharmacological activity as an inhibitor of acetyl-CoA carboxylase 1 (ACC1). Its potent inhibitory effect on ACC1 makes it a promising compound

 

 


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
  • E-mail:: info@trbextract.com
    • Download as PDF

    Product Detail

    Product Tags

    Product Name:CMS121

    Other Name:CMS-121;

    1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;

    4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);

    ACC,AcetylCoenzymeACarboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer’s,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121

    CAS NO.:1353224-53-9

    Assay:  98.0%Min

    Colour: Light yellow powder

    Packing:25kg/DRUMS

    CMS121: A Breakthrough Neuroprotective Compound for Cognitive Health and Beyond

    Introduction
    CMS121, a potent derivative of fisetin—a flavonoid found in fruits and vegetables—has emerged as a groundbreaking compound with multifaceted benefits for neurological health, anti-aging, and metabolic regulation. Supported by extensive preclinical research, CMS121 demonstrates remarkable potential in addressing Alzheimer’s disease (AD), age-related hearing loss, and obesity-related metabolic dysfunction .

    Key Benefits of CMS121

    1. Neuroprotection Against Alzheimer’s Disease
      CMS121 targets fatty acid synthase (FASN), reducing lipid peroxidation—a key driver of neuronal degeneration. In AD mouse models, CMS121 reversed memory loss and cognitive decline, with treated mice performing comparably to healthy controls in behavioral tests . Clinical trials are underway to validate these effects in humans .
    2. Preservation of Age-Related Hearing
      CMS121 protects against auditory aging in SAMP8 mice, a model for age-related hearing impairment (ARHI). It significantly preserves inner hair cell (IHC) synapses and stabilizes hearing thresholds at mid-frequencies (12–16 kHz), offering hope for mitigating “hidden” hearing loss .
    3. Metabolic and Anti-Obesity Effects
      Recent studies reveal CMS121’s ability to reverse aging-induced obesity and improve metabolic health. Treated mice exhibited reduced fat mass, increased lean mass, and enhanced glucose metabolism, linked to elevated levels of beneficial metabolites like acetyl-CoA and butyrate .

    Mechanisms of Action

    • Inhibition of FASN: By lowering FASN levels, CMS121 reduces lipid peroxidation and oxidative stress, protecting neurons and cochlear cells from damage .
    • Enhancement of Mitochondrial Function: CMS121 maintains acetyl-CoA levels, supporting brain energy metabolism and gene expression .
    • Anti-Inflammatory Properties: It suppresses neuroinflammation and microglial activation, critical in AD and metabolic disorders .

    Applications and Ongoing Research
    CMS121’s oral bioavailability and safety profile make it a promising candidate for:

    • AD Prevention and Treatment: Targeting early-stage cognitive decline .
    • Hearing Loss Interventions: Protecting against ARHI in aging populations .
    • Metabolic Syndrome Management: Addressing obesity and insulin resistance .

    Keywords
    To align with search trends, this content integrates high-value keywords such as neuroprotective compound, Alzheimer’s treatment, anti-aging supplement, hearing loss prevention, and metabolic health.

    Conclusion
    CMS121 represents a paradigm shift in addressing age-related neurological and metabolic challenges. Backed by robust preclinical data and ongoing clinical trials, it offers a holistic approach to enhancing quality of life. For more details on sourcing or partnerships, contact [Your Company Name], a leader in innovative neurohealth solutions.

     

  • Previous:
  • Next:

    • RELATED PRODUCTS