Product Name:Daidzein
Botanical Source: Soybean Extract
CAS No:486-66-8
Plant Part Used:Seed
Ingredient: Daidzein Assay: Daidzein 98% by HPLC
Colour: off-white to light yellow powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Daidzein Phytoestrogen: Comprehensive Product Description for Research and Health Applications
Overview
Daidzein (CAS: 486-66-8), a naturally occurring isoflavone and phytoestrogen, is primarily derived from soybeans, red clover, and kudzu . As a key bioactive compound, it exhibits estrogenic/antiestrogenic activity by binding to nuclear estrogen receptors, making it valuable in hormone-related research and nutraceutical development . Its multifaceted biological roles include antioxidant, anti-inflammatory, and anticancer properties, supported by extensive in vitro and in vivo studies .
Key Features
- High Purity: ≥98% (HPLC grade) for precise experimental results .
- Solubility: Soluble in DMSO (10–100 mM, depending on formulation) .
- Storage Stability:Safety Compliance: Non-hazardous for transportation (non-DOT classified) .
- Powder: Stable for 3 years at -20°C or 2 years at 4°C.
- Solution: Store at -80°C (6 months) or -20°C (1 month) .
Chemical Properties
- Molecular Formula: C₁₅H₁₀O₄
- Molecular Weight: 254.24 g/mol
- Appearance: Off-white to pale yellow crystalline powder .
- Melting Point: 247°C .
Biological Activities
- Estrogenic Modulation:
- Binds selectively to estrogen receptor-beta (ERβ), influencing gene transcription in ERβ-dependent pathways .
- Alleviates menopausal symptoms (e.g., hot flashes) by mimicking endogenous estrogen .
- Anticancer Potential:
- Induces apoptosis in cancer cells (e.g., BEL-7402 hepatoma) via ROS generation and mitochondrial membrane depolarization .
- Reduces breast and prostate cancer risk through antioxidant mechanisms .
- Cardiovascular Benefits:
- Lowers LDL cholesterol and improves lipid metabolism, supporting heart health .
- Neuroprotective and Anti-inflammatory Effects:
- Activates PPAR-α/γ receptors, reducing pro-inflammatory gene expression .
- Nanoformulations (e.g., PLGA nanoparticles) enhance bioavailability and reduce neurotoxicity for glioblastoma treatment .
Applications
- Research Fields:
- Hormone-dependent cancer studies .
- Metabolic syndrome and lipid regulation .
- Neurodegenerative disease models .
- Industrial Uses:
- Nutraceuticals for bone health (osteoporosis prevention) .
- Cosmetic formulations targeting skin aging .
Safety & Handling
- Hazards: May cause skin/eye irritation (GHS Category 2) .
- Precautions:
- Use PPE (gloves, goggles) to avoid direct contact .
- Work in a well-ventilated area to prevent inhalation of dust .
- First Aid:
- Skin contact: Wash with soap and water.
- Eye exposure: Rinse with water for 15 minutes .
Storage & Shipping
- Powder: Store desiccated at -20°C; stable for 12 months .
- Solutions: Aliquot and freeze to avoid repeated thawing .
- Transport: Shipped with ice packs for temperature-sensitive batches .
Why Choose Our Daidzein?
- Certified Quality: Rigorous HPLC/GC-MS validation .
- Custom Formulations: Available in bulk quantities (20 mg to 1 kg) for diverse applications .
- Expert Support: Detailed SDS and technical guidance provided .
Keywords
Phytoestrogen, Soy Isoflavone, Anti-Cancer Agent, PPAR Activator, Cardiovascular Health, Neuroprotection, High-Purity Daidzein, CAS 486-66-8
