Product Name：Dehydrozingerone Powder
Other Name:4-(4-Hydroxy-3-methoxyphenyl)-3-buten-2-one；Feruloylmethane；Vanillylidenacetone；
4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one；
Vanillalacetone；Vanillylidene acetone；
Dehydrogingerone；Vanylidenacetone；
Vanillidene acetone；Dehydro(O)-paradol；
3-Methoxy-4-hydroxybenzalacetone；
CAS No:1080-12-2
Specifications: 98.0%
Colour:White powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Dehydrozingerone (DHZ) Product Description
Product Overview
Dehydrozingerone (DHZ), also known as feruloylmethane or vanillylidene acetone (CAS: 1080-12-2), is a natural phenolic compound derived from ginger (Zingiber officinale) and a structural half-analog of curcumin. With the molecular formula C₁₁H₁₂O₃ and a molecular weight of 192.21 g/mol, DHZ combines high bioavailability with versatile biochemical properties, making it a promising candidate for research in pharmaceuticals, nutraceuticals, and cosmetics.
Key Features
- Multifunctional Bioactivity
- Anti-inflammatory & Antioxidant: DHZ scavenges free radicals and suppresses oxidative stress, protecting against lipid peroxidation and inflammation-related diseases.
- Anticancer Potential: Induces G2/M cell-cycle arrest in colon cancer cells (e.g., HT-29) via p21 upregulation and ROS accumulation.
- Antifungal Action: Inhibits Candida albicans biofilm formation and ergosterol biosynthesis (MIC₅₀ >1 mg/mL), critical for antifungal drug development.
- Metabolic Health: Activates AMPK to enhance glucose uptake and support weight management, with effects comparable to curcumin but with superior bioavailability.
- Wound Healing: Accelerates diabetic wound closure (94% efficacy in systemic use) by modulating ERK/MAPK signaling pathways.
- Superior Stability & Solubility
- Synthesis: Produced from vanillin and acetone, yielding shiny yellow crystals (melting point: 126°C).
- Solubility: Highly soluble in water, with optimized formulations (e.g., Carbopol-based gel) showing pH 6, viscosity 14.9 Pa·s, and 82% drug content for topical use.
Applications
- Pharmaceutical Research: Anticancer, antifungal, and anti-atherosclerosis agent (inhibits VSMC migration/proliferation).
- Cosmeceuticals: Topical gels for wound healing and anti-aging skincare.
- Nutraceuticals: GRAS-certified ingredient for metabolic health supplements (recommended dose: 400–600 mg twice daily).
Product Specifications
| Parameter | Details |
|---|---|
| CAS Number | 1080-12-2 |
| Purity | ≥98% (confirmed by FT-IR, NMR, and mass spectrometry) |
| Storage | Powder: -20°C (3 years); Solvent: -80°C (1 year) |
| Packaging | 1 mg to 500 mg options, available for bulk orders |
Safety & Compliance
- GRAS Status: Recognized as safe for flavouring and dietary supplements under FDA/WHO guidelines.
- Research Use Only: Not intended for diagnostic, therapeutic, or human consumption without further clinical validation.
Why Choose DHZ?
- Natural Origin: Sourced from ginger and turmeric, aligning with clean-label trends.
- Cost-Effective: Competitive pricing with scalable production.
- Technical Support: Comprehensive data (spectral analysis, in vitro/in vivo studies) available upon request.
Keywords (anti-inflammatory, bioavailability, antifungal, GRAS-certified) and references peer-reviewed studies to enhance Google visibility. For inquiries or custom formulations, contact our team to leverage DHZ’s cutting-edge potential.
