Cynarin Powder

Short Description:

Artichoke is a member of the milk thistle family.Artichoke grows to a height of about 2 m and produces a large, violetgreen flower head.The flower petals and fleshy flower bottoms are eaten as a vegetable throughout the world.The artichoke was used as a food and medicine by the ancient Egyptians, Greeks, and Romans.In several countries, standardized herbal drugs of artichoke are manufactured and sold as prescription drugs for high cholesterol and digestive and liver disorders. Artichoke leaf extract cynarin, an active chemical constituent in Cynara, causes an increased bile flow. The majority of the cynarin found in artichoke is located in the pulp of the leaves, though dried leaves and stems of artichoke also contain cynarin.This diuretic vegetable is of nutritional value because of its exhibiting aid to digestion, strengthening of the liver function, gall bladder function, and raising of HDL/LDL ratio. This reduces cholesterol levels, which diminishes the risk for arteriosclerosis and coronary heart disease. Aqueous extracts from artichoke leaves have also shown to reduce cholesterol by inhibiting HMG-CoA reductase and having a hypolipidemic influence, lowering blood cholesterol. Artichoke contains the bioactive agents apigenin and luteolin.

FOB Price: US 5 - 2000 / KG

Min.Order Quantity: 1 KG

Supply Ability: 10000 KG/per Month

Port: Shanghai /Beijing

Payment Terms: L/C,D/A,D/P,T/T,O/A

Shipping Terms: By sea/By Air/By Courier

E-mail:: info@trbextract.com

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Product Detail

Product Tags

Product Name:Artichoke Extract

Latin Name:Cynara Scolymus L.

CAS No.:84012-14-6

Plant Part Used:Root

Assay:Cynarin 0.5%-2.5% by UV

Colour: Brown powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Cynarin Powder: High-Purity Antioxidant Compound for Research and Health Applications

Product Overview
Cynarin Powder (CAS: 30964-13-7), also known as 1,3-Dicaffeoylquinic acid, is a natural bioactive compound derived from plants such as artichokes and sage. With a molecular formula of C25H24O12 and a molecular weight of 516.46 g/mol, it is widely recognized for its potent antioxidant, anti-inflammatory, and immunomodulatory properties . This product is ideal for research purposes, including pharmacological studies and biochemical applications.

Key Features & Benefits

Antioxidant & Anti-Inflammatory Effects
- Exhibits 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL, demonstrating strong free radical scavenging activity against DMPD+, ABTS+, O2-, DPPH1, and H2O2 .
- Reduces inflammation by suppressing TNF-α, IL-1β, and IFN-γ expression via the STAT3/NF-κB pathway, validated in colitis models .
Liver Protection & Anti-Fibrosis
- Inhibits hepatic stellate cell activation by downregulating α-SMA expression and blocking ERK/AKT signaling, suggesting potential in treating liver fibrosis .
Immunosuppressive Activity
- Blocks 87% of CD28-dependent T-cell activation by disrupting CD28-CD80 interactions, making it a candidate for autoimmune disease research .
Neuroprotective Potential
- Protects against Aβ(42)-induced neurotoxicity by activating PI3K/Akt and modulating Bcl-2/Bax pathways .

Specifications & Storage

Purity: ≥98% (HPLC-verified) .
Form: White powder.
Packaging: 20 mg/vial (customizable upon request).
Storage: Store at -20°C in dry conditions. Stable for ≥3 years in powder form .

Applications

Research: Study oxidative stress, liver diseases, neurodegenerative disorders, and immune regulation.
Pharmaceutical Development: Explore formulations targeting inflammation or metabolic syndromes.
Nutraceuticals: Potential ingredient for antioxidant supplements (subject to regulatory approval).

Safety & Compliance

Usage: For research use only. Not for human or veterinary diagnostics/therapy .
Handling: Avoid inhalation, skin contact, or ingestion. Use PPE and refer to the provided Safety Data Sheet (SDS) .