Product Name:6-Paradol
CAS No.:27113-22-0
Botanical Source:Aframomum Melegueta (Seed) Extract
Assay:50% 98% powder paradol , 6-paradol
Appearance:White Fine powder
Particle Size: 100% pass 80 mesh
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
6-Paradol Product Description
1. Product Overview
6-Paradol ([6]-Gingerone) is a bioactive phenolic compound naturally derived from ginger (Zingiber officinale) and other plants in the Zingiberaceae family. Renowned for its potent biological activities, it exhibits anti-cancer, anti-inflammatory, antioxidant, and neuroprotective properties, making it a valuable ingredient in pharmaceutical and nutraceutical applications .
2. Key Benefits
- Neuroprotective Effects: Demonstrated efficacy in improving symptoms of experimental autoimmune encephalomyelitis (EAE) in mice, with significant reduction in cumulative clinical scores after oral administration (5–10 mg/kg) .
- Anti-Inflammatory Action: Reduces microglial activation (Iba1-positive cells) in ischemic brain injury models, indicating strong anti-neuroinflammatory potential .
- Antioxidant Activity: Neutralizes oxidative stress in the central nervous system, supporting cellular health .
- Cancer Research: Binds to COX-2 in skin carcinogenesis models, suggesting a role in cancer therapy development .
3. Technical Specifications
- Chemical Name: Heptyl 4-hydroxy-3-methoxyacetophenone
- Molecular Formula: C₁₇H₂₆O₃
- Molecular Weight: 278.39 g/mol
- CAS Number: 27113-22-0
- Appearance: Pink to pale yellow powder or oil (depending on formulation) .
- Purity: 50.0%–55.0% (HPLC-verified) with ≤1.0% moisture and ≤10 ppm heavy metals .
4. Applications
- Pharmaceuticals: Used in preclinical studies for neurodegenerative diseases (e.g., multiple sclerosis) and pain management .
- Nutraceuticals: Incorporated into supplements targeting inflammation and oxidative stress .
- Cosmeceuticals: Explored for skin health due to antioxidant properties .
5. Storage & Handling
- Powder Form: Store at -20°C for up to 3 years; avoid light and moisture .
- Solution Form: Store at -80°C (in DMSO) for 1 year .
6. Safety & Compliance
- Animal Studies: Well-tolerated in mice at 5–10 mg/kg doses with no reported adverse effects .
- Regulatory: Complies with ISO standards for heavy metals, microbial limits, and solvent residues
