Cascara Sagrada Extract

Short Description:

A mild laxative action is also induced by the made from the flowers of the cascara sagrada plant. A similar laxative action is also displayed by two related European species of the Cascara, the R. frangula species – the plant and the R.cathartica species – or the , the cascara sagrada is generally preferred to these two plants as it possesses a milder laxative action and is believed to be much safer to use with patients.
Early plant chemists identified the active laxative constituents in cascara sagrada bark: anthraquinone derivatives. These compounds stimulate peristalsis, the vigorous wavelike contractions of the large intestine that keep food moving through the digestive system. When cascara speeds the process up, the body produces a softer, quicker bowel movement because the intestine has had less chance to absorb the liquid from the stool. Several studies have shown that cascara sagrada is effective in easing chronic constipation in elderly people.
Natural Cascara Sagrada Bark Extract is quite bitter to the taste and if it’s used in a liquid form (as a tea or liquid extract in water),taking cascara sagrada will require a sweetener. For this reason, some people simply prefer using cascara sagrada in tablet or capsule form.

FOB Price: US 5 - 2000 / KG

Min.Order Quantity: 1 KG

Supply Ability: 10000 KG/per Month

Port: Shanghai /Beijing

Payment Terms: L/C,D/A,D/P,T/T,O/A

Shipping Terms: By sea/By Air/By Courier

E-mail:: info@trbextract.com

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Product Detail

Product Tags

Product Name:Cascara Sagrada Extract

Latin Name：Rhamnus Purshiana

CAS No.:84650-55-5

Plant Part Used:Bark

Assay:Hydroxyanthracene Glycosides≧10.0%,20.0% by UV 10:1 20:1

Colour: Brown fine powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Cascara Sagrada Extract Hydroxyanthracene Glycosides: Product Description

1. Product Overview
Cascara Sagrada Extract is derived from the dried bark of Rhamnus purshiana (syn. Frangula purshiana), a tree native to the Pacific Northwest. Renowned for its natural laxative properties, this extract is standardized to contain 8.0–25.0% hydroxyanthracene glycosides, with ≥60% cascarosides (expressed as cascaroside A) . This formulation complies with the stringent specifications of the European Pharmacopoeia and British Pharmacopoeia, ensuring consistent potency and safety .

2. Key Active Constituents

Hydroxyanthracene Glycosides:Other Compounds: Emodin, chrysophanic acid, and tannins, which may contribute to secondary therapeutic effects .
- Primary components include cascarosides A, B, C, D (diastereoisomeric pairs) and aloe-emodin-8-O-glucoside .
- Cascarosides constitute 60–70% of total hydroxyanthracene derivatives, responsible for stimulating colonic peristalsis to relieve constipation .

3. Therapeutic Benefits

Natural Laxative: Effectively alleviates occasional and habitual constipation by enhancing intestinal motility .
Colon Tonic: Restores normal bowel function without causing dependency when used short-term .

4. Quality & Production Standards

Source: Bark aged ≥1 year to optimize bioactive content .
Extraction: Uses boiling water or hydroalcoholic solvents (≥60% ethanol) to preserve cascarosides .
Testing:
- TLC and UHPLC-DAD ensure precise quantification of hydroxyanthracene glycosides and cascarosides .
- Absorbance ratios (515 nm/440 nm) validated to avoid false results .

5. Safety & Regulatory Compliance

Contraindications:
- Not for use during pregnancy, breastfeeding, or in individuals with intestinal obstructions, Crohn’s disease, or ulcers .
- Avoid prolonged use (>1–2 weeks) to prevent electrolyte imbalance .
Label Warnings (per EU/US guidelines):
- “Do not use in children under 12 years” .
- “Discontinue if diarrhea or abdominal pain occurs” .

6. Applications

Pharmaceuticals: Core ingredient in laxative tablets and syrups .
Supplements: Available in powder form (2%–50% cascarosides) for capsules or functional foods .
Cosmetics: Potential inclusion in skincare products for anti-inflammatory properties .

7. Packaging & Storage