Fasoracetam

Short Description:

Fasoracetam is a research compound and member of the racetam family of nootropics,primarily known for their cognitive enhancing abilities.Fasoracetam is also an axiolytic and may be able to improve mood as well. This racetam works by affecting three receptors within the brain: acetylcholine,GABA and glutamate, all of three of which are involved in the creation and retention of memories.

FOB Price: US 5 - 2000 / KG

Min.Order Quantity: 1 KG

Supply Ability: 10000 KG/per Month

Port: Shanghai /Beijing

Payment Terms: L/C,D/A,D/P,T/T,O/A

Shipping Terms: By sea/By Air/By Courier

Send email to us Download as PDF

Product Detail

Product Tags

Product name : Fasoracetam

Other name: NS-105, LAM-105, Piperidine, 1-[[(2R)-5-oxo-2-pyrrolidinyl]carbonyl]-

(5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one

CAS Number: 110958-19-5

Molecular Formula: C10H16N2O2

Molecular Weight : 196.2484

Assay : 99.5%

Appearance: White crystalline powder

Fasoracetam: A Comprehensive Overview for Research Use

Product Name: Fasoracetam (NS-105, AEVI-001)
CAS Number: 110958-19-5
Molecular Formula: C₁₀H₁₆N₂O₂
Molecular Weight: 196.25
Purity: ≥98% (crystalline solid)
Storage: Store at -20°C, stable for ≥2 years .

Introduction

Fasoracetam, a member of the racetam family, is a research chemical initially developed by Nippon Shinyaku for dementia treatment. Although ineffective for vascular dementia , it has gained attention for its potential cognitive-enhancing properties and applications in neurological research. Current clinical trials focus on ADHD, anxiety, and memory disorders, particularly in individuals with mGluR gene mutations .

Mechanism of Action

Fasoracetam primarily acts on metabotropic glutamate receptors (mGluRs) and indirectly modulates GABA and acetylcholine systems:

Glutamate Agonism: Enhances mGluR activity, improving synaptic plasticity and cognitive functions .
GABA Regulation: Indirectly increases GABA synthesis by elevating glutamate availability, potentially reducing anxiety and stabilizing mood .
Cholinergic Effects: Boosts acetylcholine release in the cerebral cortex, supporting memory and learning .

Note: Most mechanisms are derived from animal studies; human data remain limited .

Potential Benefits

Cognitive Enhancement:
- Improves focus and memory recall in ADHD patients (400 mg/day in adolescents showed significant behavioral improvements) .
- Enhances learning capacity and mental performance in animal models .
Mood Stabilization:
- Reduces anxiety and depression-like symptoms via GABA modulation .
Neuroprotection:
- Prevents memory deficits induced by scopolamine or baclofen in rats .

Caution: Benefits are based on preliminary research and require further clinical validation .

Safety and Handling

Classification: Not classified as hazardous under OSHA HCS guidelines. No GHS labeling required .
Side Effects:Handling: Use impermeable gloves; avoid inhalation/ingestion. Collect spills mechanically to prevent environmental contamination .
- Mild: Headache, fatigue, digestive discomfort (may relate to choline depletion; consider stacking with citicoline) .
- Severe: Bradycardia (>1,000 mg/day) .

Research Applications

ADHD and Autism: Phase 3 trials ongoing for mGluR-related ADHD (10% of cases) .
Substance Abuse: Reduces stimulant preference in animal models, suggesting potential anti-addiction applications .
Cognitive Disorders: Investigated for dementia, epilepsy, and schizophrenia .