Product Name:Galantamine Hydrobromide

Other Name: Galanthamine hydrobromide;Galantamine HBr; Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,Hydrobromide

CAS NO：1953-04-4

Specifications: 98.0%

Colour:White powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Galanthamine is natural extracted from lycoris radiate,is a tertiary alkaloid derived from snow drop and closely related species. It acts as a reversible competitive acetylcholinesterase (ACHE) inhibitor, while acts weaker on butyrylcholinesterse(BuChE).it is used in the treatment of disorders of the central nerbous system and may be used as an antidote to nonpolarizing muscle relaxants.Galanthamine hydrobromide is a white to almost white powder; sparingly soluble in water; insoluble chloroform, ether and alcohol .

Galantamine hydrobromide is a benzazepine derived from the bulbs and flowers of narcissus, osmanthus, or canna. It is also an oral cholinesterase inhibitor. As a ligand for nicotinic acetylcholine receptors, it has been widely used to enhance neurocognitive function. Its function is to competitively and reversibly inhibit acetylcholinesterase, thereby increasing the concentration of acetylcholine. When absorbed into the bloodstream, galantamine hydrobromide is readily absorbed into various parts of the body, including the brain. It binds to nicotinic acetylcholine receptors, causing conformational changes and increasing acetylcholine release. It also works by competing with and reversing the effects of cholinesterase inhibitors. By inhibiting cholinesterase, it prevents the breakdown of acetylcholine, thereby increasing the levels and duration of this powerful neurotransmitter. Galantamine may also improve learning and memory, prevent brain inflammation, and maintain high levels of neurotransmitters by maintaining the integrity of neurons and synapses

Galantamine Hydrobromide: Product Description
Optimized for Search Engines & Global Compliance

Overview

Galantamine Hydrobromide (CAS: 1953-04-4) is a reversible, competitive acetylcholinesterase inhibitor approved by the U.S. FDA and European Medicines Agency (EMA) for the treatment of mild-to-moderate Alzheimer’s disease (AD). It uniquely combines AChE inhibition with allosteric modulation of nicotinic acetylcholine receptors (nAChRs), enhancing cholinergic neurotransmission and cognitive function .

Key Features

1. Dual Mechanism of Action
   • AChE Inhibition: Slows acetylcholine breakdown, increasing its concentration in the brain .
   • nAChR Modulation: Enhances receptor sensitivity, improving synaptic plasticity and memory .
2. Chemical Properties
   • Molecular Formula: C₁₇H₂₁NO₃·HBr
   • Molecular Weight: 368.27 g/mol
   • Appearance: White to off-white powder, sparingly soluble in water .
   • Storage: Stable at -20°C in inert conditions .
3. Formulations & Dosage
   • Immediate-Release Tablets: 4 mg, 8 mg, 12 mg .
   • Extended-Release Capsules: 8 mg, 16 mg, 24 mg (color-coded for ease of use) .
   • Dosing Regimen:

• Initial: 4 mg twice daily, increased to 8 mg after 4 weeks.
• Maintenance: 16–24 mg/day, adjusted for hepatic/renal impairment .

Clinical Benefits

• Cognitive Improvement: Preserves memory, learning, and daily functioning in AD patients for up to 12 months .
• Neuroprotection: Reduces β-amyloid plaques and neuroinflammation via cholinergic anti-inflammatory pathways .
• Caregiver Support: Lowers caregiver burden by stabilizing patient behavior .

Regulatory Compliance

• FDA & EMA Approved: Listed under USP Reference Standards (USP ID: 121587) for quality assurance .
• Global Trade Codes: HS 29399900, SITC 54149 for tariff classification .
• GMP-Certified Suppliers: Verified manufacturers (e.g., LGM Pharma) provide batch-specific Certificates of Analysis (CoA) and FDA/CEP compliance .

Safety & Precautions

• Contraindications: Hypersensitivity, gastrointestinal/urinary obstructions, post-surgical recovery .
• Side Effects: Nausea, vomiting, dizziness (minimized via dose escalation) .
• Drug Interactions: Metabolized via CYP2D6/CYP3A4; caution with enzyme inhibitors (e.g., ketoconazole) .

Applications Beyond Alzheimer’s

• Neurodegenerative Research: Potential in vascular dementia and Parkinson’s-related cognitive decline .
• Anti-Inflammatory Effects: Modulates TNF-α and NF-κB pathways, relevant for diabetes and autoimmune conditions .

 Keywords

• Galantamine HBr for Alzheimer’s
• FDA-approved acetylcholinesterase inhibitor
• Extended-release galantamine capsules
• USP-standard Galantamine Hydrobromide

Why Choose Our Product?

• Quality Assurance: HPLC-tested purity (≥98%) per USP Monographs .
• Global Logistics: HS code-compliant, fast shipping with cold-chain support .
• Technical Support: Access to SDS, clinical trial data, and regulatory documentation

 used in Alzheimer’s disease, has the principal function for dement and dysmnesia caused by organic brain damage.