Guaiazulene

Short Description:

Guaiazulene has anti-inflammatory effects and promotes the regeneration of tissue granules. It can promote burns, burn wounds, and prevent heat, radiation and chapping.

Guaiazulene is a CTFA-approved cosmetic auxiliaries that can relieve skin irritations and allergic reactions to other substances. It is a common topical anti-allergic agent and has significant anti-inflammatory properties. Used in sunscreen products to prevent or treat sunlight burns. Can be antibacterial, oral hygiene products added 0.1% can inhibit microbial growth. Guaiac wood can also be used as a cosmetic pigment.

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Product Detail

Product Tags

Product Name:Guaiazulene

CAS No: 489-84-9

Ingredient: 98% by HPLC

Colour: Dark blue crystals liquid or powder

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Guaiazulene (CAS 489-84-9) Product Description: Key Features and Applications

1. Product Overview
Guaiazulene, a bicyclic sesquiterpene (C₁₅H₁₈), is a natural compound derived from chamomile oil, guaiac wood, and marine organisms . Known for its vivid blue hue, it transitions to green upon oxidation, making it a unique colorant in cosmetics . Its molecular weight is 198.3, with a melting point of 27–29°C and a density of 0.976 g/mL .

2. Key Benefits and Mechanisms

Anti-Inflammatory & Antioxidant Activity: Inhibits pro-inflammatory cytokines (TNF-α, IL-6) and COX-2 enzymes, reducing prostaglandin synthesis and oxidative stress . Neutralizes reactive oxygen species (ROS), protecting skin from UV-induced damage .
Cellular Protection: Stabilizes cell membranes, prevents lipid peroxidation, and exhibits cytotoxic effects against cancer cells (e.g., non-small cell lung cancer) by triggering apoptosis .
Antimicrobial Properties: Effective against acne and dermatitis, enhancing its role in skincare .

3. Applications

Cosmetics: FDA-approved color additive (external use only) for creams, serums, and hair dyes. Featured in products like Winni Rose Soothing Oil and Charm Vary Cleansing Mask for its calming effects .
Pharmaceuticals: Used in anti-ulcer formulations (e.g., sodium guaiazulene sulfonate) and wound healing solutions .
Research: Studied for neuroprotective and hepatoprotective effects in Drosophila and rodent models .

4. Safety & Handling

Storage: Keep in cool, dry conditions (-20°C recommended) to maintain stability .
Safety Precautions: Harmful if swallowed (H302). Use PPE to avoid inhalation/contact . Toxicity data limited; handle per OSHA/GHS guidelines .

5. Market and Suppliers

Global Suppliers: Major distributors in Europe (Aladdin Scientific), Asia (TCI Chemicals), and North America (Sigma-Aldrich) .
Pricing: Varies by quantity (e.g., ¥113–1,470 for 25 mg–5 g) . Market trends show growing demand in skincare and pharmaceuticals .

6. Why Choose Guaiazulene?

Natural Origin: Sourced sustainably from chamomile and marine extracts .
Multifunctional: Combines aesthetic appeal with therapeutic benefits, ideal for premium formulations.
Compliance: Meets FDA and EU cosmetic regulations for safe external use .

Contact Us
For bulk orders or COA inquiries, reach out to certified suppliers like Aladdin Scientific (US) or TCI Chemicals (Asia) .