A cikin 1913, masanin kimiyyar Sweden Farfesa Kylin ya gano abin da ke daure da kelp, fucoidan, a Jami'ar Uppsala.Har ila yau, an san su da "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", da dai sauransu, sunan Ingilishi "Fucoidan".Abu ne na polysaccharide mai narkewa da ruwa wanda ya ƙunshi fucose mai ɗauke da ƙungiyoyin sulfate.Yana da yawa a cikin saman slime na algae launin ruwan kasa (kamar ciyawa, wakame spores, da kelp).Abinda ke ciki shine kusan 0.1%, kuma abun ciki a cikin busassun kelp shine kusan 1%.Abu ne mai matukar amfani ga ciyawa mai kima.
Na farko, tasirin fucoidan
A halin yanzu Japan ita ce kasa mafi tsayi a duniya.A lokaci guda kuma, Japan tana ɗaya daga cikin mafi ƙasƙanci na cututtukan cututtuka.A cewar masana abinci mai gina jiki, daya daga cikin muhimman dalilai na lafiyar mutanen Japan na iya kasancewa da alaka da cin abincin teku akai-akai.Fucoidan da ke cikin algae mai launin ruwan kasa kamar kelp abu ne mai aiki tare da ayyuka daban-daban na ilimin lissafi.Ko da yake Farfesa Kylin ya gano shi a cikin 1913, sai a 1996 ne aka buga Fucoidan a taron Ƙungiyar Ciwon daji na Japan na 55.Rahoton da ke cewa "na iya haifar da apoptosis cell ciwon daji" ya tayar da damuwa a cikin al'ummar ilimi kuma ya haifar da haɓaka a cikin bincike.
A halin yanzu, ƙungiyar likitocin suna gudanar da bincike kan ayyuka daban-daban na ilimin halitta na fucoidan, kuma sun buga dubban takardu a cikin mujallolin likita na duniya, suna tabbatar da cewa fucoidan yana da ayyuka daban-daban na kwayoyin halitta, irin su anti-tumor, inganta gastrointestinal tract, da antioxidant , Inganta rigakafi. , antithrombotic, rage karfin jini, antiviral effects.
(I) Fucoidan yana inganta tasirin gastrointestinal
Helicobacter pylori shine helical, microaerobic, gram-negative bacilli wanda ke da matukar bukata akan yanayin girma.Ita ce kawai nau'in ƙwayoyin cuta da aka sani a halin yanzu suna rayuwa a cikin ɗan adam.Helicobacter pylori kamuwa da cuta yana haifar da gastritis da fili na narkewa.Ulcers, lymphoproliferative gastric lymphomas, da dai sauransu, suna da mummunan tsinkaye ga ciwon daji na ciki.
Hanyoyin cututtuka na H. pylori sun haɗa da: (1) adhesion: H. pylori zai iya wucewa a matsayin laka mai laushi kuma yana manne da ƙwayoyin epithelial na ciki;(2) kawar da acid na ciki don amfanin rayuwa: H. pylori yana sakin urease, kuma Urea a cikin ciki yana amsawa don samar da iskar ammonia, wanda ke kawar da acid na ciki;(3) yana lalata mucosa na ciki: Helicobacter pylori yana fitar da gubar VacA kuma yana lalata sel na saman mucosa na ciki;(4) yana samar da chloramine mai guba: iskar ammonia kai tsaye yana lalata mucosa na ciki, kuma yana mai da iskar oxygen Halin yana haifar da chloramine mai guba;(5) Yana haifar da amsa mai kumburi: Domin kare kariya daga Helicobacter pylori, adadi mai yawa na fararen jini suna taruwa akan mucosa na ciki don samar da amsa mai kumburi.
Sakamakon fucoidan akan Helicobacter pylori sun haɗa da:
1. Hana yaduwar Helicobacter pylori;
A cikin 2014, ƙungiyar binciken Yun-Bae Kim a Jami'ar Kasa ta Chungbuk a Koriya ta Kudu ta buga wani bincike da ke nuna cewa fucoidan yana da sakamako mai kyau na ƙwayoyin cuta, kuma fucoidan a cikin adadin 100µg / ml na iya hana yaduwar H. pylori gaba daya.(Lab Anim Res2014: 30 (1), 28-34.)
2. Hana mannewa da mamayewa na Helicobacter pylori;
Fucoidan ya ƙunshi ƙungiyoyin sulfate kuma yana iya ɗaure zuwa Helicobacter pylori don hana shi mannewa ga ƙwayoyin epithelial na ciki.A lokaci guda, Fucoidan na iya hana samar da urease da kare yanayin acidic na ciki.
3. Sakamakon Antioxidant, rage yawan samar da guba;
Fucoidan shine maganin antioxidant mai kyau, wanda zai iya saurin lalata oxygen free radicals kuma ya rage samar da chloramine mai cutarwa.
4. Anti-mai kumburi sakamako.
Fucoidan na iya hana ayyukan lectin zaɓaɓɓu, haɓakawa da heparanase, da rage amsawar kumburi.(Helicobacter, 2015, 20, 89-97.)
Bugu da ƙari, masu binciken sun gano cewa fucoidan yana da tasiri mai mahimmanci wajen inganta lafiyar hanji kuma yana da tasiri mai tasiri na hanyoyi biyu a kan hanji: inganta maƙarƙashiya da enteritis.
A cikin 2017, ƙungiyar bincike daga Farfesa Ryuji Takeda na Jami'ar Kansai na Kimiyyar Jin Dadin Jama'a a Japan sun gudanar da bincike.Sun zabi marasa lafiya 30 masu fama da maƙarƙashiya kuma sun raba su gida biyu.An ba ƙungiyar gwaji 1 g na fucoidan kuma an ba ƙungiyar kulawa da wuribo.Watanni biyu bayan gwajin, an gano cewa adadin kwanakin bayan gida a kowane mako a cikin rukunin gwajin fucoidan ya karu daga matsakaicin kwanaki 2.7 zuwa kwanaki 4.6, kuma ƙarar bayan gida da laushi ya ƙaru sosai.(Ayyukan Abinci a Lafiya da Cuta 2017, 7: 735-742.)
A cikin 2015, ƙungiyar Farfesa Nuri Gueven na Jami'ar Tasmania, Ostiraliya, ta gano cewa fucoidan na iya inganta ciwon ciki a cikin mice yadda ya kamata, a gefe guda, yana iya taimakawa beraye su dawo da nauyi da kuma ƙara taurin bayan gida;a daya bangaren kuma, zai iya rage nauyin hanji da magudanar ruwa.Yana rage kumburi a cikin jiki.(PLoS DAYA 2015, 10: e0128453.)
B) Antitumor sakamako na fucoidan
Bincike kan tasirin antitumor na fucoidan a halin yanzu ya fi damuwa da da'irar ilimi, kuma an sami sakamako mai yawa na bincike.
1. Tsarin sake zagayowar kwayar cutar tumo
A cikin 2015, Farfesa Lee Sang Hun da sauran su a Jami'ar Soonchunhyang a Koriya ta Kudu da sauran masu bincike sun gano cewa fucoidan yana hana bayyanar cyclin Cyclin da cyclin kinase CDK a cikin ƙwayoyin tumor ta hanyar daidaita yanayin ci gaban ƙwayoyin ciwon daji na hanji, yana tasiri ga al'ada mitosis. kwayoyin cutar kansa.Stagnate ƙwayoyin ƙwayar cuta a cikin lokaci na pre-mitotic kuma suna hana haɓakar ƙwayar ƙwayar cuta.(Rahoton Magungunan Kwayoyin Halitta, 2015, 12, 3446.)
2.Induction of tumor cell apoptosis
A cikin 2012, wani binciken da ƙungiyar Quan Li ta buga a Jami'ar Qingdao ta gano cewa fucoidan na iya kunna siginar apoptosis na ƙwayoyin tumor-Bax apoptosis protein, haifar da lalacewar DNA ga ƙwayoyin kansar nono, haɗuwar chromosome, da haifar da apoptosis na ƙwayoyin tumor., Hana haɓakar ƙwayoyin ƙwayar cuta a cikin mice.(Plos One, 2012, 7, e43483.)
3.Hana ƙwayar ƙwayar ƙwayar cuta
A cikin 2015, Chang-Jer Wu da sauran masu bincike daga Jami'ar Tekun Taiwan ta kasa sun buga binciken da ke nuna cewa fucoidan na iya kara yawan maganganun da ke hana nama (TIMP) magana da kuma daidaita maganganun matrix metalloproteinase (MMP), don haka yana hana metastasis cell tumor.(Magungunan Maris 2015, 13, 1882.)
4.Hana kumburin angiogenesis
A cikin 2015, ƙungiyar bincike ta Tz-Chong Chou a Cibiyar Kiwon Lafiya ta Taiwan ta gano cewa fucoidan na iya rage yawan haɓakar haɓakar haɓakar ƙwayoyin cuta (VEGF), hana haɓakar ciwace-ciwacen ciwace-ciwacen ciwace-ciwacen ciwace-ciwacen ciwace-ciwacen ciwace-ciwace, da yunwar ciwace-ciwace. Mafi girman toshe yaduwa da metastasis na ƙwayoyin ƙari.(Magungunan Maris 2015, 13, 4436.)
5. Kunna garkuwar jiki
A shekara ta 2006, Farfesa Takahisa Nakano na Jami'ar Kitasatouniversity da ke Japan ya gano cewa fucoidan na iya inganta garkuwar jiki da kuma amfani da na'urar rigakafi ta majiyyaci don kashe kwayoyin cutar kansa musamman.Bayan fucoidan ya shiga cikin hanji, ana iya gane shi ta hanyar ƙwayoyin rigakafi, yana haifar da siginar da ke kunna tsarin rigakafi, kuma yana kunna kwayoyin NK, kwayoyin B, da kwayoyin T, ta haka ne ke samar da kwayoyin da ke daure ga kwayoyin cutar kansa da kuma kwayoyin T masu kashe kansa. Kwayoyin.Ƙaddamar da kashe kwayoyin cutar kansa, yana hana ci gaban kwayar cutar kansa.(Planta Medica, 2006, 72, 1415.)
Production na Fucoidan
Abubuwan da ke cikin rukunin sulfate a cikin tsarin kwayoyin halittar fucoidan muhimmin alama ne wanda ke ƙayyade ayyukan ilimin halittarsa, kuma yana da mahimmancin abun ciki na tsarin-ayyukan dangantakar fucoidan.Don haka, abun ciki na rukunin sulfate muhimmin ma'auni ne don kimanta ingancin fucoidan da alaƙa-aiki-aiki.
Kwanan nan, Hukumar Kula da Abinci da Magunguna ta tabbatar da lasisin samar da abinci na fucoidan polysaccharide, kuma ta ba da shi ga rukunin Qingdao Mingyue Seaweed, wanda ke nufin cewa rukunin ruwan teku na Mingyue ya daɗe yana noman teku sama da shekaru 50.Sami takaddun shaida na hukuma.An ba da rahoton cewa, Mingyue Seaweed Group ya gina layin samar da fucoidan tare da fitowar tan 10 na shekara-shekara.A nan gaba, zai ba da cikakken wasa ga tasirin "maganin magani da abinci" da haske a cikin aikin abinci na manyan masana'antar kiwon lafiya.
Mingyue Seaweed Group, a matsayin kamfani da aka amince da shi don samar da abinci na fucoidan, yana da shekaru masu yawa na ƙwarewar samarwa.Fucoidan da aka samar da shi samfurin haɓaka fasaha ne na ainihin kelp maida hankali / foda.Yin amfani da ingantaccen abinci mai launin ruwan kasa algae a matsayin albarkatun kasa, ƙarin tsarkakewa da rarrabuwa bisa ga fasahar hakar halitta, ba wai kawai inganta dandano da ɗanɗanon samfurin ba, har ma yana haɓaka abun ciki na polysaccharide fucoidan (tsarki), wanda za'a iya amfani dashi a ciki. fannoni da yawa kamar abinci mai aiki da abinci na lafiya..Yana da abũbuwan amfãni daga high samfurin tsarki da kuma babban abun ciki na ayyuka kungiyoyin;nauyi cire karafa, babban aminci;desalination da kifi, dandano da kuma dandano inganta.
Aikace-aikacen Fucoidan
A halin yanzu, akwai samfuran fucoidan da yawa waɗanda aka haɓaka kuma ana amfani da su a Japan, Koriya ta Kudu, Amurka da sauran ƙasashe, irin su fucoidan mai daɗaɗɗa, fucoidan cire ɗanyen capsules, da mai mai super fucoidan ruwan teku.Abinci na aiki kamar su Qingyou Le Group na Seaweed, Rockweed Treasure, Brown Algae Shuka Abin sha
A cikin 'yan shekarun baya-bayan nan, "Rahoton Matsayin Gina Jiki da Cututtukan Mazaunan Sinawa" ya nuna cewa, tsarin abinci na mazauna kasar Sin ya canza, kuma ana samun karuwar cututtuka masu saurin kisa.Manyan ayyukan kiwon lafiya da suka shafi "maganin cututtuka" sun jawo hankali sosai.Yin amfani da fucoidan don haɓakawa da samar da ƙarin abinci mai aiki zai bincika cikakken amfani da ƙimar fucoidan don ba da rai da lafiya, wanda ke da mahimmanci ga ci gaban "maganin lafiya da abinci mai gina jiki" babban masana'antar kiwon lafiya.
Haɗin samfur: https://www.trbextract.com/1926.html
Lokacin aikawa: Maris 24-2020