Sialic acid foda

Sialic acid (SA), a kimiyance aka sani da “N-acetylneuraminic acid,” carbohydrate ne da ke faruwa ta halitta.An samo asali ne daga mucin glandon submandibular, saboda haka sunan.Sialic acid yawanci yana cikin nau'in oligosaccharides, glycolipids ko glycoproteins.A cikin jikin mutum, kwakwalwa tana da mafi girman abun ciki na sialic acid.Abun da ke cikin sialic acid a cikin al'amarin launin toka ya ninka sau 15 na gabobin ciki kamar hanta da huhu.Babban tushen abinci na sialic acid shine madarar nono, wanda kuma ana samunsa a cikin madara, kwai da cuku.

A cikin magani, glycolipids dauke da sialic acid ana kiransa gangliosides, wanda ke taka muhimmiyar rawa wajen samarwa da ci gaban kwakwalwa da tsarin juyayi.A lokaci guda kuma, nazarin dabbobi ya nuna cewa raguwar matakan ganglioside yana da alaƙa da rashin abinci mai gina jiki da wuri da kuma rage ikon ilmantarwa, yayin da kari tare da sialic acid zai iya inganta halayyar ilmantarwa na dabba.isassun wadatar sialic acid na iya zama mahimmanci musamman ga ci gaban al'ada na aikin kwakwalwa a cikin yara masu ƙarancin nauyin haihuwa.Bayan an haifi jariri, sialic acid a cikin madarar nono yana da mahimmanci don tabbatar da ci gaban su na yau da kullum.Bincike ya nuna cewa matakan sialic acid a cikin iyaye mata bayan haihuwa suna raguwa a kan lokaci.Sabili da haka, ci gaba da cin isasshen adadin sialic acid yayin daukar ciki da kuma bayan daukar ciki na iya taimakawa wajen kiyaye matakan sialic acid a cikin jiki.Bugu da ƙari, abin da ke cikin sialic acid yana da alaƙa da mahimmanci tare da abun ciki na DHA, yana nuna cewa yana yiwuwa a haɗa shi da tsarin kwakwalwa da haɓaka aikin kwakwalwa a cikin jarirai, dukansu biyu na iya zama masu amfani ga farkon ci gaban kwakwalwa.

Bincike ya nuna cewa lokacin zinari na ci gaban kwakwalwar ɗan adam yana tsakanin shekarun 2 zuwa 2 shekaru.Wannan mataki lokaci ne mai mahimmanci don daidaita lambar tantanin halitta, haɓaka ƙara, kamalar aiki, da samuwar hanyar sadarwa na jijiyoyi.Don haka, a dabi'ance iyaye mata masu hankali za su kula da shan isassun adadin sialic acid yayin daukar ciki.Bayan an haifi jariri, nono shine hanya mai mahimmanci don ƙara sialic acid ga jariri, saboda kimanin 0.3-1.5 na sialic acid a kowace millilita na madarar nono.A zahiri, duk dabbobi masu shayarwa, gami da mutane, suna iya haɗa sialic acid daga hanta da kansu.Duk da haka, ci gaban hanta na jarirai bai yi girma ba tukuna, kuma buƙatar saurin girma da ci gaban kwakwalwa na iya iyakance haɗin sialic acid, musamman ga jarirai da ba su kai ba.Saboda haka, sialic acid a cikin madarar nono yana da mahimmanci don tabbatar da girma da ci gaban jariri.
Masu bincike a Ostiraliya sun gano cewa jariran da ake shayar da nono suna da yawan adadin sialic acid a cikin kurwar gaba fiye da jarirai masu cin nama.Wannan na iya inganta samuwar synapses, taimakawa ƙwaƙwalwar jariri don samar da ingantaccen tsarin tsari, da ƙarfafa ci gaban tsarin juyayi.

Menene Sialic acid

Sialic acidrukuni ne na abubuwan da suka samo asali na neuraminic acid (N- ko O-musanya abubuwan da suka samo asali neuraminic acid).Yawancin lokaci a cikin nau'i na oligosaccharides, glycolipids ko glycoproteins.

Sialic acidHakanan shine sunan mafi yawan mamba na wannan rukunin - N-acetylneuramine acid (Neu5Ac ko NANA).

Sialic acid iyali

An san shi ga kusan membobi 50, duk abubuwan da suka samo asali daga mummunan cajin 9-carbon sugar neuraminic acid.

N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic

acid (Neu5Gc) da deaminoneuramine (KDN) su ne ainihin monomer ɗin sa.

N-acetylneuraminic acid shine kawai nau'in Sialic Acid a jikinmu.

Sialic Acid da Bird's Nest

Saboda Sialic acid yana da wadata a cikin gidan tsuntsu, ana kuma kiransa acid nest tsuntsu, wanda shine muhimmiyar alamar ƙaddamar da gidan tsuntsaye.

Sialic acid shine babban kayan abinci mai gina jiki a cikin gida na Bird, kusan 3% -15% ta nauyi.

Daga cikin duk sanannun abinci, gidan Tsuntsaye ya ƙunshi mafi girman abun ciki na Sialid acid, kusan sau 50 fiye da sauran abinci.

Gidan tsuntsu 1g yana daidai da kwai 40 idan muka sami adadin Sialic Acid iri ɗaya.

Sialic acid tushen abinci

Gabaɗaya, tsire-tsire ba su ƙunshi Sialic acid ba.Babban wadatar Sialic acid shine madarar ɗan adam, nama, kwai, da cuku.

Abubuwan da ke cikin jimlar Sialic acid a cikin abinci na al'ada (µg/g ko µg/ml).

Za mu iya ganin cewa Sialic acid a cikin madarar ɗan adam yana da yawa, wanda shine babban sinadari don haɓaka kwakwalwar jariri.

Amma abun ciki na Sialic acid ya sha bamban a lokuta daban-daban Nonon Dan Adam

Ruwan nono colostrum 1300 +/- 322 mg/l

Bayan kwanaki 10 983 +/- 455 mg/l

Ruwan madarar jaririn da ba a kai ba 197 +/- 31 mg/l

Matsalolin madara da aka daidaita 190 +/- 31 mg/l

Matsalolin madara da aka daidaita 100 +/- 33 mg/l

Maganin madara mai biyo baya 100 +/- 33 mg/l

Tsarin madara na tushen soya 34 +/- 9 mg/l

Idan aka kwatanta da madarar nono, madarar jarirai ta ƙunshi kusan 20% Sialic acid daga madarar ɗan adam, yayin da jariri zai iya samun 25% Sialic acid daga madarar nono kawai.

Ga jaririn da ba a kai ba, Sialic acid ya fi mahimmanci fiye da lafiyayyan jariri a cikin ci gaban Brain.

Nazarin Sialic Acid akan Foda Milk

"Sakamakon ya nuna cewa abun ciki na sialic acid na kwakwalwa yana taka muhimmiyar rawa wajen tantance hali.Wata ƙungiya ta lura da ingantaccen koyo tare da jiyya na sialic acid kyauta a cikin rodents."

Bayanin CAB: Ra'ayoyi a Noma, Kimiyyar Dabbobi, Abinci, da Halitta

Albarkatun 2006 1, No. 018, Shin sialic acid a cikin abincin madara ga kwakwalwa? ， Bing Wang

"Ƙarshen ita ce mafi girma ganglioside na kwakwalwa da kuma glycoprotein sialic acid maida hankali a cikin jarirai da ke ciyar da madarar ɗan adam yana nuna karuwar synaptogenesis da bambance-bambance a ci gaban neurodevelopment."

Am J Clin Nutr 2003;78:1024–9.An buga a Amurka.© 2003 American Society for Clinical Nutrition, Brain ganglioside, da glycoprotein sialic acid a cikin shayarwa idan aka kwatanta da jarirai masu cin nama, Bing Wang

"Magungunan ƙwayoyin jijiyoyi sun ƙunshi sialic acid sau 20 fiye da sauran nau'in membranes, yana nuna cewa sialic acid yana da muhimmiyar rawa a tsarin jijiyoyi."

Jaridar European Journal of Clinical Nutrition, (2003) 57, 1351-1369, Matsayi da yuwuwar sialic acid a cikin abincin ɗan adam, Bing Wang

Aikace-aikacen N-Acetylneuramine

Madara Foda

A halin yanzu, Garin nonon uwa masu shayarwa da nono, foda madarar jarirai, da abubuwan gina jiki sun ƙunshi Sialic Acid akan Kasuwa.

Ga Mata masu shayarwa

Ga Baby Milk foda 0-12 watanni

Don samfurin Kiwon lafiya

Don Abin Sha

Tun da Sialic acid yana da kyakkyawan ikon iya narkewar ruwa, kamfanoni da yawa suna ƙoƙarin haɓaka abubuwan sha na Sialic acid don lafiyar Brain ko ƙara cikin samfuran madara.

N-Acetylneuraminic acid Tsaro

N-Acetylneuraminic acid yana da aminci sosai.A halin yanzu, babu wani labari mara kyau da aka ruwaito akan Sialic acid.

Amurka, China, da gwamnatocin EU sun amince da Sialic acid da za a yi amfani da su a cikin kayayyakin Kula da Abinci da Lafiya.

Amurka

A cikin 2015, N-Acetyl-D-neuraminic acid (Sialic acid) an ƙaddara Gabaɗaya An gane shi azaman Safe (GRAS)

China

A cikin 2017, Gwamnatin China ta amince da N-Acetylneuraminic acid a matsayin Sabon Kayan Abinci na Albarkatun.

EU

Amintaccen acid N-acetyl-d-neuramine na roba azaman abincin labari a ƙarƙashin Ka'ida (EC) No 258/97

A ranar 16 Oktoba 2015, Hukumar Tarayyar Turai ta ba da zaɓin marayu (EU/3/12/972) zuwa Ultragenyx UK Limited, United Kingdom, don sialic acid (wanda aka fi sani da aceneuramic acid) don maganin GNE myopathy.

Ra'ayin Kimiyya game da tabbatar da da'awar lafiya da ke da alaƙa da sialic acid da koyo da ƙwaƙwalwa (ID 1594) bisa ga Mataki na 13 (1) na Dokokin (EC) No 1924/2006

Sashi

CFDA yana ba da shawarar 500mg / rana

Abincin novel yana ba da shawarar 55mg/rana ga Jarirai da 220mg/rana ga Matasa matasa da masu matsakaicin shekaru

Ayyukan N-acetylneuramine

Ƙwaƙwalwar ƙwaƙwalwa da haɓakar hankali

Ta hanyar yin hulɗa tare da membranes cell membranes da synapses, Sialic acid yana ƙara yawan amsawar synapses a cikin ƙwayoyin jijiya na kwakwalwa, don haka inganta haɓaka ƙwaƙwalwar ajiya da hankali.

Masana kimiyyar New Zealand sun yi jerin gwaje-gwaje don tabbatar da muhimmiyar rawar da acid nest na tsuntsu ke takawa wajen haɓaka hankalin yara.A karshe, masu binciken sun yi ittifaki da cewa, kara yawan acid din gida na tsuntsaye a cikin jarirai, zai iya kara yawan sinadarin tsuntsu a cikin kwakwalwa, ta yadda kwakwalwa za ta iya koyo.

Inganta iya sha na hanji

Dangane da yanayin yanayi mai sauƙi na kishiyar jinsi, ma'adanai masu inganci da wasu bitamin da ke shiga cikin hanji ana samun sauƙin haɗuwa tare da ƙaƙƙarfan caja na gida na tsuntsu, don haka shawar bitamin da ma'adanai na hanji.An inganta iyawa daga gare ta.

Haɓaka ƙaƙƙarfan kawar da ƙwayoyin cuta na hanji

Sialic acid akan furotin tantanin halitta yana taka muhimmiyar rawa wajen haɓaka ikon ganewar tantanin halitta, detoxification na cutar kwalara, rigakafin kamuwa da cutar Escherichia coli, da daidaita tsarin furotin na jini.

Tsawon rai

Sialic acid yana da tasiri mai karewa da daidaitawa akan sel, kuma rashin sialic acid na iya haifar da raguwar rayuwar kwayoyin jini da raguwar glycoprotein metabolism.

Haɓaka sabon magani don Sialic Acid

Masana kimiyya suna ƙoƙarin magance cututtukan gastrointestinal tare da sialic acid anti-adhesion kwayoyi.Magungunan sialic acid na anti-adhesive na iya maganin Helicobacter pylori don magance ciwon ciki da duodenal ulcers.

Sialic acid shine glycoprotein.Yana ƙayyade fahimtar juna da ɗaurin sel kuma yana da tasirin maganin kumburi na asibiti kamar aspirin.

Sialic acid magani ne don cututtuka na tsakiya ko na waje da cututtuka na demyelinating;sialic acid shima maganin tari ne.

Sialic acid a matsayin albarkatun kasa na iya haɓaka jerin mahimman magunguna masu sukari, anti-virus, anti-tumor, anti-inflammatory, da kuma kula da ciwon daji na tsofaffi suna da sakamako mai ban mamaki.

Tsarin samar da Sialic Acid

Abubuwan da aka fara farawa sune glucose, masara steep barasa, glycerin, da magnesium sulfate.Kuma muna amfani da fasahar fermented.Yayin wannan tsari, muna amfani da hanyar haifuwa don kiyaye kayan tsabta.Sannan ta hanyar hydrolysis, maida hankali, bushewa, da fasa.Bayan duk matakai, muna samun samfurin ƙarshe.Kuma QC ɗinmu za ta yi amfani da HPLC don gwada ingancin kayan kowane tsari kafin mu isar da shi ga abokan ciniki.

Sunan samfur: Sialic acid;N-Acetylneuraminic acid

Wani Suna: 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactononulosonic acid Lactaminic acid NANA N-Acetylsialic acid

Asalin: Gidan tsuntsu mai cin abinci
Musamman: 20% - 98%
Bayyanar: farin farin foda
KASA NO.: 131-48-6
MW: 309.27
Saukewa: C11H19NO9

Wurin Asalin: China

Adana: Ajiye a wuri mai sanyi & busassun wuri, nisantar hasken kai tsaye da zafi.
Inganci: Shekaru biyu idan an adana su da kyau.

AIKI:

1. Anti-virus aiki.
2. Aikin rigakafin ciwon daji.
3. Anti-kumburi aiki.
4. Ayyukan kariya daga cututtukan ƙwayoyin cuta.
5. Sarrafa ikon tsarin rigakafi.
6. Ƙarfafawa ga pigmentation.
7. Canjin sigina a cikin ƙwayoyin jijiya.
8. taka muhimmiyar rawa wajen haɓaka kwakwalwa da koyo.
9. A matsayin precursor don kera magunguna da yawa.