ʻAka Azelaic 98%na HPLC | Laʻau Laʻau & Mea Hoʻomaʻamaʻa
1. Nānā Huahana
Azelaic Acid(CAS123-99-9) he ʻakika dicarboxylic saturated maoli me ke kumu molekala C₉H₁₆O₄ a me ke kaumaha molekala 188.22 g/mol. ʻO kā mākou papa hoʻomaʻemaʻe 98% i hōʻoia ʻia e HPLC e hoʻokō i nā kūlana USP/EP, i hoʻopaʻa ʻia no ka hoʻokumu ʻana i nā dermatological a me nā noi ʻoihana.
Nā mea kiko'ī
- Maʻemaʻe: ≥98% (HPLC-ELSD i hōʻoia ʻia, pau nā haumia <0.2%)
- Nānā: ʻO ka pauka kristal keʻokeʻo
- Lae hehee: 109-111°C
- Puni paila: 286°C ma 100 mmHg
- Solubility: 2.14 g/L i ka wai (25°C), hiki ke hoʻoheheʻe ʻia i ka ethanol/alkali
2. Hoʻohālikelike Kemika
2.1 Hōʻoia Hana
- Palapala NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H, 4.10 (t, 2H kēlā me kēia), 4.10 (t, 2H kēlā me kēia), 4.10 COOH) - HPLC Chromatogram:
Manawa Hoʻopaʻa: 20.5 min (nui kiʻekiʻe), nā kiʻekiʻe haumia <0.1% ma 31.5 / 41.5 min
2.2 Kūlana Kūlana maikaʻi
| ʻĀpana | ʻano hana | Koina ʻae |
|---|---|---|
| Hoʻāʻo | HPLC-ELSD (Agilent 1200) Kona: Purospher Star RP-C18 Māhele Mobile: Methanol/Water/Acetic Acid gradient | 98.0-102.0% |
| Metala Kaumaha | ICP-MS | ≤10 ppm |
| Nā mea hoʻoheheʻe koena | GC-FID (HP-5MS kolamu) Derivatization me HMDS | Ethanol <0.5% |
3. Laau Laau Laau
3.1 Ka Pono Dermatological
- Acne Vulgaris:
Hoʻemi i nā comedones e 65% i nā hoʻokolohua 12-wiki (20% cream) ma o:- Ka hana antimicrobialC. acnes(MIC₅₀ 256 μg/mL)
- ʻO Tyrosinase inhibition (IC₅₀ 3.8 mM) no ka hyperpigmentation post-inflammatory
- Rosacea:
Hōʻike ka 15% gel i 72% ka emi ʻana o ka erythema (vs 43% placebo) ma o:- ʻO ka hoʻopale ʻana i ka ROS Antioxidant (EC₅₀ 8.3 μM)
- Hoʻopau MMP-9 i nā keratinocytes
3.2 Nā Kūlana Kūlana
| Puka Puka | Manaʻo ʻia % | Nā memo kūpono |
|---|---|---|
| Kalima/Gela | 15-20% | Hōʻalo i ka methylparaben (ke kumu 42% degradation) |
| Liposomal | 5-10% | E hoʻohana i ka phosphate buffer pH7.4 + soybean lecithin |
4. Nā mea hoʻonani
4.1 Whitening Synergy
- ʻO nā hui ʻoi loa:
- 2% AzA + 5% Vitamin C: 31% hoʻemi melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x hoʻonui i ka hoʻohuihui collagen
4.2 ʻIkepili Paʻa
| Kūlana | Ka helu hoʻohaʻahaʻa |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Hōʻike UV | 1.2% (me ka pale o TiO₂) |
5. Hoohana Hana Hana
- Polimer precursor:
- ʻO ka nylon-6,9 synthesis (ka hopena hopena> 85% ma 220°C)
- ʻO ka mea hoʻoheheʻe ʻino no nā mea hao hao (0.1M solution e hōʻemi i ka corrosion e 92%)
6. Palekana & Hooponopono
6.1 Hōʻikeʻike kino
| ʻĀpana | Ka hopena |
|---|---|
| LD₅₀ (ʻIole) | >5000 mg/kg |
| ʻIli ʻIli | Māmā (OECD 404) |
| Pilikia Ocular | Māhele 2B |
6.2 Hoʻokō honua
- Nā palapala hōʻoia:
- US FDA Drug Master File
- EU REACH Kakau
- ISO 9001:2015 Pūnaehana Pono
7. Packaging & Storage
| Ka nui | pahu pahu | Kumukuai (EXW) |
|---|---|---|
| 25 kg | Pahu HDPE + ʻeke Alu | $4,800 |
| 1 kg | ʻOmole aniani ʻAmber | $220 |
| 100 g | ʻeke paʻa pālua | $65 |
Ka mālama ʻana: 2-8°C ma kahi maloʻo (ʻae ʻia ka mahana o ka lumi inā <25°C/60% RH)
8. NUI
Nīnau: Hiki iaʻu ke hoʻohana i ka waikawa azelaic me ka niacinamide?
A: ʻAe, hōʻike ka ʻikepili lapaʻau i ka 10% AzA + 4% niacinamide e hoʻomaikaʻi i ka hoʻomanawanui 37% vs AzA wale nō
Nīnau: He aha ke ola o ka papa?
A: 36 mahina ke mālama pono ʻia. Hāʻawi ʻia ka COA kikoʻī
9. Hoike
- ʻIkepili kikoʻī NMR
- Hana HPLC-ELSD
- Haʻawina kūpaʻa
- Hoʻoikaika kino
