HANA FISETIN

ʻO kahi pūhui kūlohelohe i loaʻa i loko o nā strawberries a me nā huaʻai a me nā mea kanu ʻē aʻe hiki ke kōkua i ka pale ʻana i ka maʻi o Alzheimer a me nā maʻi neurodegenerative e pili ana i ka makahiki, hōʻike ʻia ka noiʻi hou.

Ua ʻike nā mea noiʻi mai ka Salk Institute for Biological Studies ma La Jolla, CA, a me nā hoa hana ʻo ka mālama ʻana i nā hiʻohiʻona ʻiole o ka ʻelemakule me ka fisetin i alakaʻi i ka emi ʻana o ka emi ʻana o ka cognitive a me ka mumū o ka lolo.

ʻO ka mea kākau moʻolelo koʻikoʻi ʻo Pamela Maher, o ka Cellular Neurobiology Laboratory ma Salk, a me nā hoa hana i hōʻike hou aku nei i kā lākou ʻike ma The Journals of Gerontology Series A.

ʻO Fisetin kahi flavanol i loaʻa i nā ʻano huaʻai a me nā mea kanu, e like me nā strawberries, persimmons, nā ʻāpala, nā hua waina, nā aniani, a me nā kukama.

ʻAʻole wale ka hana ʻana o fisetin ma ke ʻano he mea pena kala no nā huaʻai a me nā mea kanu, akā ua hōʻike pū ʻia nā haʻawina he mau waiwai antioxidant ka pūhui, ʻo ia ka mea hiki ke kōkua i ka hoʻopaʻa ʻana i ka pōʻino cell i hana ʻia e nā radical manuahi.Ua hōʻike pū ʻia ʻo Fisetin e hōʻemi i ka mumū.

I nā makahiki he 10 i hala iho nei, ua alakaʻi ʻo Maher a me nā hoa hana i nā haʻawina he nui e hōʻike ana i nā waiwai antioxidant a me nā mea anti-inflammatory o fisetin hiki ke kōkua i ka pale ʻana i nā cell lolo i nā hopena o ka ʻelemakule.

ʻO kekahi o ia noiʻi, i paʻi ʻia ma 2014, ua ʻike ʻo fisetin i hōʻemi i ka nalowale o ka hoʻomanaʻo ʻana i nā hiʻohiʻona ʻiole o ka maʻi o Alzheimer.Eia nō naʻe, ua hoʻopaʻa ʻia kēlā haʻawina i nā hopena o ka fisetin i nā ʻiole me ka ʻohana Alzheimer's, ka mea i ʻike ʻia e ka poʻe noiʻi e pili ana i ka 3 pakeneka o nā hihia Alzheimer āpau.

No ka noiʻi hou, ʻimi ʻo Maher a me ka hui e hoʻoholo inā loaʻa paha i ka fisetin nā pōmaikaʻi no ka maʻi sporadic Alzheimer, ʻo ia ke ʻano maʻamau e kū mai ana me ka makahiki.

No ka loaʻa ʻana o kā lākou ʻike, ua hoʻāʻo ka poʻe noiʻi i ka fisetin i nā ʻiole i hana ʻia i ka genetically engineered a hiki i ka wā ma mua, ka hopena i kahi ʻano ʻiole o ka maʻi sporadic Alzheimer.

I ka piha ʻana o nā ʻiole ʻelemakule ma mua o 3 mau mahina, ua māhele ʻia lākou i ʻelua pūʻulu.Ua hānai ʻia kekahi pūʻulu i ka nui o ka fisetin me kā lākou meaʻai i kēlā me kēia lā no 7 mahina, a hiki i ka makahiki 10.ʻAʻole i loaʻa i ka hui ʻē aʻe ka pūhui.

Hōʻike ka hui i ka 10 mahina o ka makahiki, ua like ke ʻano kino a me ka noʻonoʻo o nā ʻiole me nā ʻiole 2 makahiki.

ʻO nā rodents a pau i hoʻāʻo ʻia i ka noʻonoʻo a me ka hoʻāʻo ʻana i ke aʻo ʻana, a ua loiloi nā mea noiʻi i nā ʻiole no nā pae o nā māka i pili i ke kaumaha a me ka mumū.

Uaʻike nā mea noiʻiʻo nāʻiole 10 mau mahina i loaʻaʻole i ka fisetin i hōʻike i ka piʻiʻana o nā hōʻailona e pili ana i ke kaumaha a me ka mumū, a ua hana nui lākou i nā ho'āʻo cognitive ma mua o nāʻiole i mālamaʻia me ka fisetin.

I loko o ka lolo o nāʻiole i mālamaʻoleʻia, uaʻike nā mea noiʻi heʻelua mauʻano neurons i maʻa mau i ka anti-inflammatory - astrocytes a me microglia - ke hoʻolaha maoli nei i ka mumū.Akā naʻe, ʻaʻole kēia ka hihia no nā ʻiole 10 mau mahina i mālama ʻia me ka fisetin.

ʻO ka mea ʻē aʻe, ua ʻike nā mea noiʻi ua hoʻohālikelike ʻia ka ʻano a me ka hana naʻau o nā ʻiole i mālama ʻia me nā ʻiole o 3 mau mahina i mālama ʻole ʻia.

Manaʻo ka poʻe noiʻi e hōʻike ana kā lākou ʻike e hiki i ka fisetin ke alakaʻi i kahi hoʻolālā pale hou no Alzheimer, a me nā maʻi neurodegenerative e pili ana i ka makahiki.

"Ma muli o kā mākou hana e hoʻomau nei, manaʻo mākou he mea kōkua paha ka fisetin ma ke ʻano he pale no nā maʻi neurodegenerative e pili ana i ka makahiki, ʻaʻole wale ʻo Alzheimer, a makemake mākou e hoʻoikaika i ka noiʻi ikaika ʻana iā ia," wahi a Maher.

Eia naʻe, ʻike nā mea noiʻi e koi ʻia nā hoʻokolohua lapaʻau kanaka e hōʻoia i kā lākou hopena.Manaʻo lākou e hui pū me nā mea noiʻi ʻē aʻe e hoʻokō i kēia pono.

“ʻAʻole nā ​​kānaka ʻiole, ʻoiaʻiʻo.Akā ua lawa nā mea like a mākou e manaʻo ai he pono ke nānā pono ʻo fisetin, ʻaʻole wale no ka mālama ʻana i ka maʻi sporadic AD [Alzheimer's maʻi] akā no ka hōʻemi ʻana i kekahi o nā hopena cognitive e pili ana i ka ʻelemakule, maʻamau.