I ka makahiki 1913, ua ʻike ke kanaka ʻepekema Suedena ʻo Professor Kylin i ka ʻāpana paʻa paʻa o ke kelp, fucoidan, ma ke Kulanui ʻo Uppsala.ʻIke ʻia ʻo "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", etc., ʻo ka inoa Pelekane ʻo "Fucoidan".He mea wai-soluble polysaccharide i haku ʻia me ka fucose me nā pūʻulu sulfate.Aia ma ka ʻili o ka limu ʻeleʻele (e like me ka limu, wakame spores, a me ke kelp).ʻO ka maʻiʻo ma kahi o 0.1%, a ʻo ka mea i loko o ka kelp maloʻo ma kahi o 1%.He mea waiwai nui ia i ka limu.
ʻO ka mea mua, ka pono o ka fucoidan
ʻO Iapana i kēia manawa ka ʻāina me ka lōʻihi o ke ola ma ka honua.I ka manawa like, aia ʻo Iapana kekahi o nā helu haʻahaʻa loa o nā maʻi maʻi.Wahi a ka poʻe meaʻai meaʻai, ʻo kekahi o nā kumu koʻikoʻi o ke olakino o ka poʻe Kepani e pili ana i ka ʻai mau ʻana i nā meaʻai limu.ʻO Fucoidan i loko o nā algae ʻeleʻele e like me ke kelp he mea ikaika me nā hana physiological like ʻole.ʻOiai ua ʻike ʻia e Professor Kylin i ka makahiki 1913, ʻaʻole hiki i ka makahiki 1996 i paʻi ʻia ka Fucoidan ma ka 55th Japanese Cancer Society Conference.ʻO ka hōʻike e "hiki ke hoʻoulu i ka apoptosis cell cancer" ua hoʻāla i ka hopohopo nui i ka kaiāulu kula a ua hoʻoulu i ka noiʻi.
I kēia manawa, ke alakaʻi nei ke kaiāulu lapaʻau i ka noiʻi ʻana i nā hana olaola like ʻole o fucoidan, a ua paʻi i nā kaukani o nā pepa i loko o nā nūpepa lapaʻau honua, e hōʻoiaʻiʻo ana i ka fucoidan he mau hana olaola like ʻole, e like me ka anti-tumor, hoʻomaikaʻi i ka ʻōpū o ka ʻōpū, a me antioxidant , Hoʻonui i ka palekana. , antithrombotic, haʻahaʻa ke koko, hopena antiviral.
(I) Hoʻomaikaʻi ʻo Fucoidan i ka maikaʻi o ka ʻōpū
ʻO Helicobacter pylori he helical, microaerobic, gram-negative bacilli e koi nui ana i nā kūlana ulu.ʻO ia wale nō ka ʻano microbial i ʻike ʻia e ola i loko o ka ʻōpū o ke kanaka.ʻO ka maʻi Helicobacter pylori ke kumu o ka gastritis a me ka digestive tract.ʻO nā maʻi maʻi maʻi, lymphoproliferative gastric lymphomas, a me nā mea ʻē aʻe, he maikaʻi ʻole ka wānana no ka maʻi maʻi ʻōpū.
ʻO nā hana pathogenic o H. pylori e komo pū ana: (1) adhesion: Hiki i ka H. pylori ke hele ma ke ʻano he papa mucus a pili i nā cell epithelial gastric;(2) hoʻokaʻawale i ka ʻakika ʻōpū no ka pono o ke ola ʻana: Hoʻokuʻu ʻo H. pylori i ka urease, a ʻo ka Urea i loko o ka ʻōpū e hoʻoulu ai i ke kinoea amonia, kahi e hoʻopau ai i ka ʻakika ʻōpū;(3) hoʻopau i ka ʻōpū o ka ʻōpū: hoʻokuʻu ʻo Helicobacter pylori i ka ʻawaʻawa VacA a hoʻopau i nā ʻili o ka ʻōpū o ka ʻōpū;(4) hoʻopuka i ka chloramine toxin: hoʻopau pololei ke kinoea amonia i ka mucosa o ka ʻōpū, a me ka oxygen reactive.(5) Hoʻoulu i ka pane ʻeha: I mea e pale aku ai iā Helicobacter pylori, ʻākoakoa ka nui o nā keʻokeʻo keʻokeʻo ma luna o ka mucosa ʻōpū e hana i kahi pane ʻeha.
ʻO nā hopena o ka fucoidan e kūʻē iā Helicobacter pylori penei:
1. Kāohi i ka hoʻonui ʻana o Helicobacter pylori;
I ka makahiki 2014, ua paʻi ka hui noiʻi ʻo Yun-Bae Kim ma Chungbuk National University ma South Korea i kahi haʻawina e hōʻike ana i ka fucoidan he hopena antibacterial maikaʻi loa, a ʻo ka fucoidan ma kahi ʻano o 100µg / mL hiki ke pale i ka hoʻonui ʻana o H. pylori.(Lab Anim Res2014: 30 (1), 28-34.)
2. Kāohi i ka hoʻopili ʻana a me ka hoʻouka ʻana o Helicobacter pylori;
Loaʻa iā Fucoidan nā pūʻulu sulfate a hiki iā ia ke hoʻopaʻa iā Helicobacter pylori e pale aku iā ia mai ka pili ʻana i nā cell epithelial gastric.I ka manawa like, hiki iā Fucoidan ke kāohi i ka hana ʻana o ka urease a pale i ke kaiapuni acidic o ka ʻōpū.
3. ʻO ka hopena Antioxidant, hoʻemi i ka hana toxin;
He antioxidant maikaʻi ʻo Fucoidan, hiki iā ia ke ʻoki koke i nā radical manuahi a hoʻemi i ka hana ʻana o ka chloramine toxin ʻino.
4. Ka hopena anti-inflammatory.
Hiki i ka Fucoidan ke kāohi i ka hana o ka lectin koho, hoʻohui a me ka heparanase, a hoʻemi i ka pane inflammatory.(Helicobacter, 2015, 20, 89–97.)
Eia kekahi, ua ʻike ka poʻe noiʻi he hopena koʻikoʻi ka fucoidan i ka hoʻomaikaʻi ʻana i ke olakino o ka ʻōpū a loaʻa iā ia ka hopena ʻelua ala i ka ʻōpū: hoʻomaikaʻi i ka constipation a me enteritis.
I ka makahiki 2017, ua hana kahi hui noiʻi mai Professor Ryuji Takeda o Kansai University of Welfare Sciences ma Iapana i kahi noiʻi.Ua koho lākou i 30 mau maʻi me ka constipation a māhele iā lākou i ʻelua pūʻulu.Ua hāʻawi ʻia ka hui hoʻokolohua i ka 1 g o fucoidan a ua hāʻawi ʻia ka hui hoʻomalu i kahi placebo.ʻElua mau mahina ma hope o ka hoʻāʻo ʻana, ua ʻike ʻia ka nui o nā lā defecation i kēlā me kēia pule ma ka hui hoʻāʻo e lawe ana i ka fucoidan i hoʻonui ʻia mai ka awelika o 2.7 mau lā a hiki i 4.6 mau lā, a piʻi nui ka defecation a me ka palupalu.(Functional Foods in Health and Disease 2017, 7: 735-742.)
Ma 2015, ua ʻike kahi hui o Professor Nuri Gueven o ke Kulanui o Tasmania, Australia, hiki i ka fucoidan ke hoʻomaikaʻi maikaʻi i ka enteritis i nā ʻiole, ma kekahi ʻaoʻao, hiki ke kōkua i nā ʻiole e hoʻihoʻi i ke kaumaha a hoʻonui i ka paʻakikī o ka defecation;ma ka ʻaoʻao ʻē aʻe, hiki ke hoʻemi i ke kaumaha o ke kolonā a me ka spleen.Hoʻemi i ka ʻāʻī ma ke kino.(PLoS ONE 2015, 10: e0128453.)
B) Ka hopena antitumor o fucoidan
ʻO ka noiʻi e pili ana i ka hopena antitumor o fucoidan i kēia manawa ka mea hopohopo nui e nā poʻe hoʻonaʻauao, a ua loaʻa ka nui o nā hopena noiʻi.
1. Hoʻoponopono i ka pōʻaiapili o ke kino
I ka makahiki 2015, ua ʻike ʻo Polofesa Lee Sang Hun a me nā mea ʻē aʻe ma ke Kulanui o Soonchunhyang ma South Korea a me nā mea noiʻi ʻē aʻe ua pale ʻo fucoidan i ka hōʻike ʻana o ka cyclin Cyclin a me ka cyclin kinase CDK i loko o nā cell tumor ma o ka hoʻoponopono ʻana i ka pōʻai o ka ulu ʻana o nā maʻi maʻi maʻi colon kanaka, e pili ana i ka mitosis maʻamau o nā pūnaeʻa tumora.E hoʻopaʻa i nā pūnaʻi maʻi maʻi i ka wā pre-mitotic a keʻakeʻa i ka hoʻonui ʻana o nā cell tumor.(Molecular Medicine Reports, 2015, 12, 3446.)
2.Induction o ka tumor cell apoptosis
I ka makahiki 2012, he noiʻi i paʻi ʻia e ka hui noiʻi ʻo Quan Li ma ke Kulanui ʻo Qingdao ua ʻike ʻo fucoidan hiki ke hoʻāla i ka hōʻailona apoptosis o nā pūnaewele tumora-Bax apoptosis protein, hoʻopōʻino i ka DNA i nā puʻupuʻu maʻi maʻi umauma, chromosome aggregation, a hoʻoulu i ka apoptosis kūʻokoʻa o nā pūnaewele tumo., Kāohi i ka ulu ʻana o nā ʻiole maʻi maʻi.(Plos One, 2012, 7, e43483.)
3.Inhibit tumor cell metastasis
I ka makahiki 2015, ua hoʻopuka ʻo Chang-Jer Wu a me nā mea noiʻi ʻē aʻe mai ka National Taiwan Ocean University i ka noiʻi e hōʻike ana e hiki i ka fucoidan ke hoʻonui i ka ʻike ʻana o ka tissue inhibitory factor (TIMP) a me ka hoʻoponopono ʻana i ka matrix metalloproteinase (MMP) hōʻike, no laila ke kāohi nei i ka metastasis cell tumor.(Mar. Drugs 2015, 13, 1882.)
4.Inhibit tumor angiogenesis
I ka makahiki 2015, ua ʻike ka hui noiʻi ʻo Tz-Chong Chou ma Taiwan Medical Center e hiki i ka fucoidan ke hōʻemi i ka hana ʻana o ka vascular endothelial growth factor (VEGF), kaohi i ka neovascularization o nā ʻōpū, ʻoki i ka lako meaʻai o nā ʻōpū, pōloli i nā maʻi koko. ʻoi loa Kāohi i ka hoʻolaha a me ka metastasis o nā pūnaewele tumo.(Mar. Drugs 2015, 13, 4436.)
5.E hoʻoikaika i ke kino o ke kino
I ka makahiki 2006, ua ʻike ʻo Polofesa Takahisa Nakano o ke Kulanui ʻo Kitasatouniversity ma Iapana e hiki i ka fucoidan ke hoʻoikaika i ka pale ʻana o ke kino a hoʻohana i ka ʻōnaehana pale ponoʻī o ka mea maʻi no ka pepehi ʻana i nā maʻi kanesa.Ma hope o ke komo ʻana o ka fucoidan i loko o ka ʻāpana ʻōpū, hiki ke ʻike ʻia e nā cell immune, hoʻopuka i nā hōʻailona e hoʻāla ai i ka ʻōnaehana pale, a hoʻāla i nā pūnaewele NK, B, a me T cell, a laila e hana ana i nā antibodies e hoʻopaʻa i nā pūnaeau maʻi kanesa a me nā cell T e pepehi ai i ka maʻi kanesa. pūnaewele.Pepehi kikoʻī o nā pūnaewele maʻi maʻi, kaohi ʻana i ka ulu ʻana o ka maʻi kanesa.(Planta Medica, 2006, 72, 1415.)
Hana ʻia ʻo Fucoidan
ʻO ka maʻiʻo o nā pūʻulu sulfate i loko o ka molecular structure o fucoidan he hōʻailona koʻikoʻi ia e hoʻoholo ai i kāna hana physiological, a he mea koʻikoʻi hoʻi ia o ka pilina hana-hana o fucoidan.No laila, ʻo ka maʻiʻo o ka pūʻulu sulfate kahi mea koʻikoʻi no ka loiloi ʻana i ka maikaʻi fucoidan a me ka pilina hana-hana.
I kēia mau lā, ua hōʻoia hope ʻia ka laikini hana ʻai meaʻai fucoidan polysaccharide e ka Food and Drug Administration a hāʻawi ʻia iā Qingdao Mingyue Seaweed Group, ʻo ia hoʻi ka Mingyue Seaweed Group e mahi hohonu ana i ka moana no nā makahiki he 50.E kiʻi i ka palapala hōʻoia.Ua hōʻike ʻia ua kūkulu ʻo Mingyue Seaweed Group i kahi laina hana fucoidan me ka puka makahiki he 10 tons.I ka wā e hiki mai ana, e hāʻawi ʻo ia i ka pāʻani piha i kāna hopena "lāʻau lapaʻau a me ka homology meaʻai" a hoʻomālamalama i ke kahua meaʻai hana o ka ʻoihana olakino nui.
ʻO Mingyue Seaweed Group, ma ke ʻano he ʻoihana i ʻae ʻia no ka hana ʻana i ka meaʻai fucoidan, he mau makahiki o ka ʻike hana.ʻO ka fucoidan i hana ʻia e ia he huahana hoʻomaikaʻi ʻenehana o ke kumu kelp concentrate / pauka.ʻO ka hoʻohana ʻana i ka algae brown algae meaʻai kiʻekiʻe e like me ka mea maka, hoʻomaʻemaʻe hou a hoʻokaʻawale ʻia ma muli o ka ʻenehana unuhi kūlohelohe, ʻaʻole wale e hoʻomaikaʻi i ka ʻono a me ka ʻono o ka huahana, akā hoʻonui pū i ka fucoidan polysaccharide content (purity), hiki ke hoʻohana ʻia i loko. nui nā ʻano e like me nā meaʻai hana a me nā meaʻai olakino..Loaʻa iā ia nā pōmaikaʻi o ka maʻemaʻe huahana kiʻekiʻe a me nā ʻike kiʻekiʻe o nā hui hana;ka wehe ʻana i nā metala kaumaha, palekana kiʻekiʻe;desalination a me ka iʻa, ka ʻono a me ka hoʻomaikaʻi ʻana i ka ʻono.
Ka hoohana ana o Fucoidan
I kēia manawa, nui nā huahana fucoidan i hoʻomohala ʻia a hoʻohana ʻia ma Iapana, South Korea, ʻAmelika Hui Pū ʻIa a me nā ʻāina ʻē aʻe, e like me ka fucoidan concentrated, fucoidan extract maka capsules, a me ka lubricating seaweed super fucoidan.ʻO nā meaʻai kūpono e like me ka Qingyou Le o Seaweed Group, Rockweed Treasure, Brown Algae Plant Inu
I nā makahiki i hala iho nei, ua hōʻike ʻia ka "Report on the Status of Chinese Resident' Nutrition and Chronic Diseases" ua loli ke ʻano o ka ʻai ʻana o nā kamaʻāina Kina, a ke piʻi nei ka piʻi ʻana o nā maʻi maʻi.ʻO nā papahana olakino nui e pili ana i ka "mālama ʻana i nā maʻi" ua huki nui ʻia.ʻO ka hoʻohana ʻana i ka fucoidan e hoʻomohala a hana i nā meaʻai ʻoi aku ka maikaʻi e ʻimi piha i ka waiwai o ka fucoidan e hāʻawi i ke ola a me ke olakino, he mea nui ia no ka hoʻomohala ʻana i kahi "lāʻau olakino olakino a me ka homology meaʻai" ʻoihana olakino nui.
Huahana Huahana:https://www.trbextract.com/1926.html
Ka manawa hoʻouna: Mar-24-2020