ʻO ka Covid-19, a i ʻole i kapa ʻia ʻo 2019-nCoV a i ʻole SARS-CoV-2 virus, no ka ʻohana o Coronavirus.No ka mea aia ʻo SARS-CoV-2 i ka β genus Coronavirus pili loa ia me MERS-CoV a me SARS-CoV - i hōʻike ʻia hoʻi e hōʻeha i nā hōʻailona koʻikoʻi o ka maʻi maʻi maʻi i nā maʻi maʻi ma mua.Ua hōʻike ʻia a paʻi ʻia ke ʻano genetic o 2019-nCoV.
ʻO ka mea hou o kēia ʻano o ka maʻi maʻi, ʻo ia ka nui o nā kānalua e pili ana i kāna ʻano, no laila ke kakahiaka nui e hoʻoholo ai inā hiki i nā mea kanu lāʻau a i ʻole nā huihui ke kōkua maoli i ke kaiāulu ma ke ʻano he prophylactic agents a i ʻole nā mea kūpono i nā lāʻau anti-coronavirus e kūʻē iā Covid. -19.Eia nō naʻe, ma muli o ka like kiʻekiʻe o Covid-19 me nā maʻi maʻi SARS-CoV a me MERS-CoV i hōʻike mua ʻia, ua paʻi mua ʻia ka noiʻi ʻana e pili ana i nā mea kanu lāʻau, i hōʻike ʻia e hoʻohana i nā hopena anti-coronavirus, he alakaʻi koʻikoʻi ia i ka loaʻa ʻana o ka anti-coronavirus. nā mea kanu lāʻau, hiki ke hoʻoikaika i ka maʻi SARS-CoV-2.
Ma hope o ka haʻalele ʻana o SARS-CoV, i hōʻike mua ʻia i ka makahiki 2003[iii], ua hoʻāʻo ikaika nā ʻepekema e hoʻohana i nā pūhui antiviral e kūʻē iā SARS-CoV.Ua alakaʻi kēia i kahi pūʻulu o ka poʻe loea ma Kina e nānā ma mua o 200 mau mea kanu lāʻau lapaʻau Kina no nā hana antiviral e kūʻē i kēia maʻi coronavirus.
Ma waena o kēia mau mea, ʻehā mau mea i hōʻike ʻia i nā hopena paʻa i ka SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (a fern), Artemisia annua (Sweet wormwood) a me Lindera aggregate (he lālā lāʻau evergreen ʻono o ka ʻohana laurel. ).ʻO nā hopena antiviral o kēia mau mea i hilinaʻi ʻia a mai nā haʻahaʻa haʻahaʻa o ka extract a hiki i ke kiʻekiʻe, e ʻokoʻa ana no kēlā me kēia mea kanu lāʻau.Ua hōʻike ʻo Lycoris radiata i ka hana anti-viral ikaika loa e kūʻē i ka maʻi maʻi.[iv]
Ua kūlike kēia hopena me kēlā o nā pūʻulu noiʻi ʻelua ʻē aʻe, i manaʻo ʻia ua hōʻike ʻia kahi mea hana i loko o nā aʻa Licorice, ʻo Glycyrrhizin, he hana anti-SARS-CoV ma ke kāohi ʻana i kāna hana hou ʻana.[v] [vi] I kekahi ke aʻo ʻana, ua hōʻike pū ʻo Glycyrrhizin i ka hana antiviral i ka wā i hoʻāʻo ʻia no kāna mau hopena antiviral in vitro ma 10 mau ʻokoʻa maʻi maʻi o SARS coronavirus.ʻO Baicalin - kahi mea kanu Scuttelaria baicalensis (Skullcap) - ua hoʻāʻo ʻia i loko o kēia noiʻi ma lalo o nā kūlana like a ua hōʻike pū i ka hana antiviral e kūʻē i ka SARS coronavirus. -1 virus in vitro i nā haʻawina mua.[viii] [ix] Eia naʻe, pono e hoʻomaopopo ʻia ʻaʻole hiki ke hoʻopili ʻia nā ʻike in vitro me ka maikaʻi o ka lāʻau lapaʻau in vivo.ʻO kēia no ka mea ʻaʻole hiki i ka waha waha o kēia mau mea i loko o ke kanaka ke hoʻokō i kahi ʻano serum koko e like me ka mea i hoʻāʻo ʻia i loko o ka vitro.
Ua hōʻike pū ʻo Lycorine i ka hana antiviral ikaika e kūʻē iā SARS-CoV.3 Ua hōʻike ʻia kekahi mau hōʻike ma mua e like me ka Lycorine he mau hana antiviral ākea a ua hōʻike ʻia ua hōʻike ʻo ia i kahi hana pale i ka maʻi Herpes Simplex (type I)[x] a me ka Poliomyelitis virus kekahi.[xi]
"ʻO nā mea kanu ʻē aʻe i hōʻike ʻia e hōʻike ana i ka hana antiviral e kūʻē iā SARS-CoV ʻo Lonicera japonica (Japanese Honeysuckle) a me ka mea kanu Eucalyptus kaulana, a me Panax ginseng (kahi kumu) ma o kāna mea hana ʻo Ginsenoside-Rb1."[xii]
Hōʻike nā hōʻike mai nā haʻawina i ʻōlelo ʻia ma luna a me kekahi mau noiʻi honua ʻē aʻe he nui nā mea kanu lāʻau lapaʻau i hōʻike i nā hana antiviral e kūʻē i nā coronaviruses[xiii] [xiv] a ʻo kā lākou hana nui e like me ke kaohi ʻana i ka hoʻopiʻi viral.[xv] Kina Ua hoʻohana nui ʻo ia i nā lāʻau lapaʻau Kina kuʻuna no ka mālama ʻana i ka SARS i nā hihia he nui.
Hiki paha i ia mau mea kanu ke lilo i mau moho no ka hoʻomohala ʻana i nā lāʻau antiviral hou no ka pale ʻana a i ʻole ka mālama ʻana i ka SARS?
DISCLAMER: Ua kākau ʻia kēia ʻatikala no ka ʻike ʻike wale nō a ʻaʻole i manaʻo ʻia e hoʻololi i ka ʻōlelo aʻoaʻo lapaʻau ʻoihana, ka maʻi a i ʻole ka mālama ʻana.Inā manaʻo ʻoe he mau hōʻailona paha e pili ana i ka Covid-19 a i ʻole kekahi maʻi ʻē aʻe, e kelepona koke i kāu kauka.
[i] Zhou, P., Yang, X., Wang, X. et al., 2020. ʻO kahi maʻi maʻi pneumonia e pili ana me kahi coronavirus hou o ke kumu ʻōpeʻa paha.Natura 579, 270–273 (2020).https://doi.org/10.1038/s41586-020-2012-7
[ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC a me Garry, RF, 2020. Ke kumu kokoke o SARS-CoV-2.Nature Medicine, pp.1-3.
[iii] Ka palena manawa pane CDC SARS.Loaʻa ma https://www.cdc.gov/about/history/sars/timeline.htm.Loaʻa
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG a me Li, RS, 2005. Ka ʻike ʻana o nā pūhui kūlohelohe me nā hana antiviral e kūʻē i ka coronavirus pili i ka SARS.Ka noiʻi antiviral, 67 (1), pp.18-23.
[v] Cinatl, J., Morgenstem, B. a me Bauer, G., 2003. ʻO Glycyrrhizin, kahi mea ikaika o nā aʻa licorice a me ka replication o ka coronovirus pili i ka SARS.Lancet, 361(9374), pp.2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW a me Cinatl, J., 2005. Antiviral Activity of Glycyrrhizic Acid Derivatives against ʻO SARS− Coronavirus.Journal of medicinal chemistry, 48(4), pp.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW a me Guan, Y., 2004. In vitro susceptibility o 10 clinical isolates o SARS coronavirus i waeia antiviral pūhui.Journal of Clinical Virology, 31 (1), pp.69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. a me Tokunaga, T., 1998. ʻO Baicalin, he mea hoʻopale o Hana ʻia ka HIV-1 in vitro.Ka noiʻi antiviral, 37 (2), pp.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW a me Wang, JM, 2000. Flavonoid baicalin inhibits HIV-1 maʻi ma ka pae o ka viral komo.Nā kamaʻilio noiʻi biochemical a me biophysical, 276 (2), pp.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. a me Kobayashi, S., 1989. Ka hopena o nā alkaloids i hoʻokaʻawale ʻia mai Amaryllidaceae ma ka herpes simplex virus.Ka noiʻi ma ka virology, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. a me Alderweireldt, F., 1982. Mea kanu antiviral agents.III.Hoʻokaʻawale ʻia nā alkaloids mai Clivia miniata Regel (Amaryl-lidaceae).Nūpepa o nā mea kūlohelohe, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. and Liang, FS, 2004 .Nā hana o ka National Academy of Sciences, 101 (27), pp.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS a me Hou, CC, 2007. Specific Loaʻa i nā mea kanu terpenoids a me nā lignoids nā hana antiviral ikaika e kūʻē i ka maʻi maʻi maʻi hanu maʻi coronavirus.Journal of medicinal chemistry, 50(17), pp.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW a me nā hale kiaʻi, GHN, 1995. ʻO ka hōʻike antiviral o nā lāʻau lapaʻau British Columbian.Journal of Ethnopharmacology, 49 (2), pp.101-110.
[xv] Jassim, SAA a me Naji, MA, 2003. Novel antiviral agents: a medicinal plant perspective.Journal of applied microbiology, 95(3), pp.412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. a me Liu, JP, 2020. Hiki ke hoʻohana ʻia ka lāʻau Kina no ka pale ʻana i ka maʻi maʻi corona 2019 (COVID -19)?He loiloi o nā moʻolelo kahiko, nā hōʻike noiʻi a me nā papahana pale o kēia manawa.Chinese Journal of Integrative Medicine, pp.1-8.
E like me ka hana maʻamau me nā pūnaewele ʻoihana āpau, hoʻohana kā mākou pūnaewele i nā kuki, nā faila liʻiliʻi i hoʻoiho ʻia i kāu kelepona, e hoʻomaikaʻi i kou ʻike.
Hōʻike kēia palapala i ka ʻike a lākou e hōʻiliʻili ai, pehea mākou e hoʻohana ai a me ke kumu e pono ai mākou e mālama i kēia mau kuki i kekahi manawa.E kaʻana pū mākou pehea e hiki ai iā ʻoe ke pale i kēia mau kuki mai ka mālama ʻana akā hiki ke hoʻohaʻahaʻa a 'haʻi' paha i kekahi mau mea o ka hana pūnaewele.
Hoʻohana mākou i nā kuki no nā kumu like ʻole i hōʻike ʻia ma lalo nei.ʻO ka mea pōʻino, i ka hapanui o nā hihia, ʻaʻohe koho maʻamau o ka ʻoihana no ka hoʻopau ʻana i nā kuki me ka hoʻopau ʻole ʻana i ka hana a me nā hiʻohiʻona a lākou e hoʻohui ai i ka pūnaewele.Manaʻo ʻia ʻoe e waiho i nā kuki āpau inā ʻaʻole ʻoe maopopo inā pono ʻoe iā lākou a ʻaʻole paha, inā hoʻohana ʻia lākou e hāʻawi i kahi lawelawe āu e hoʻohana ai.
Hiki iā ʻoe ke pale i ka hoʻonohonoho ʻana i nā kuki ma ka hoʻoponopono ʻana i nā hoʻonohonoho ma kāu polokalamu kele pūnaewele (e ʻike i ke koho "Kōkua" o kāu polokalamu kele e hana i kēia).E makaʻala e pili ana ka hoʻopau ʻana i nā kuki i ka hana o kēia a me nā pūnaewele ʻē aʻe āu e kipa aku ai.No laila, ʻōlelo ʻia ʻaʻole ʻoe e hoʻopau i nā kuki.
Ma kekahi mau hihia kūikawā hoʻohana pū mākou i nā kuki i hāʻawi ʻia e nā poʻe ʻekolu hilinaʻi.Ke hoʻohana nei kā mākou pūnaewele i [Google Analytics] ʻo ia kekahi o nā hoʻonā ʻikepili laha loa a hilinaʻi ʻia ma ka pūnaewele no ke kōkua ʻana iā mākou e hoʻomaopopo i kāu hoʻohana ʻana i ka pūnaewele a me nā ala e hiki ai iā mākou ke hoʻomaikaʻi i kou ʻike.Hiki i kēia mau kuki ke hahai i nā mea e like me ka lōʻihi o kou hoʻolilo ʻana ma ka pūnaewele a me nā ʻaoʻao āu e kipa aku ai i hiki iā mākou ke hoʻomau i ka hana ʻana i nā mea hoihoi.No ka 'ike hou aku e pili ana i nā kuki Google Analytics, e nānā i ka 'ao'ao Google Analytics official.
ʻO Google Analytics ka mea hana loiloi a Google e kōkua i kā mākou pūnaewele e hoʻomaopopo i ke ʻano o ka hana ʻana o nā malihini me kā lākou waiwai.Hiki iā ia ke hoʻohana i nā kuki e hōʻiliʻili i ka ʻike a hōʻike i nā helu helu hoʻohana pūnaewele me ka ʻole o ka ʻike pilikino i nā malihini kipa iā Google.ʻO ka kuki nui i hoʻohana ʻia e Google Analytics ʻo ka kuki '__ga'.
Ma waho aʻe o ka hōʻike ʻana i nā helu helu hoʻohana pūnaewele, hiki ke hoʻohana pū ʻia ʻo Google Analytics, me kekahi o nā kuki hoʻolaha, e kōkua i ka hōʻike ʻana i nā hoʻolaha e pili ana i nā waiwai Google (e like me Google Search) a ma ka pūnaewele puni honua a e ana i nā pilina me nā hoʻolaha Google hōʻike. .
Hoʻohana i nā IP Address.ʻO kahi helu IP he helu helu e ʻike ai i kāu kelepona ma ka Pūnaewele.Hiki iā mākou ke hoʻohana i kāu helu IP a me kāu ʻano polokalamu kele pūnaewele e kōkua i ka nānā ʻana i nā ʻano hoʻohana a me ka ʻike ʻana i nā pilikia ma kēia pūnaewele a hoʻomaikaʻi i ka lawelawe a mākou e hāʻawi nei iā ʻoe.Akā me ka ʻole o ka ʻike hou aʻe, ʻaʻole ʻike kāu IP IP iā ʻoe ma ke ʻano he kanaka.
Kou Koho.I kou komo ʻana i kēia pūnaewele, ua hoʻouna ʻia kā mākou kuki i kāu polokalamu kele pūnaewele a mālama ʻia ma kāu kelepona.Ma ka hoʻohana ʻana i kā mākou pūnaewele, ʻae ʻoe i ka hoʻohana ʻana i nā kuki a me nā ʻenehana like.
Manaʻolana ua wehewehe ʻia ka ʻike ma luna nei iā ʻoe.E like me ka mea i haʻi mua ʻia, inā ʻaʻole ʻoe maopopo inā makemake ʻoe e ʻae i nā kuki a ʻaʻole paha, ʻoi aku ka palekana o ka waiho ʻana i nā kuki inā pili ia me kekahi o nā hiʻohiʻona āu e hoʻohana ai ma kā mākou pūnaewele.Eia naʻe, inā ʻoe e ʻimi nei i ka ʻike hou aku, a laila e ʻoluʻolu e hoʻokaʻaʻike mai iā mākou ma o ka leka uila ma [email protected]
Pono e ʻae ʻia ka Kuki Pono Pono i nā manawa a pau i hiki iā mākou ke mālama i kāu mau makemake no nā hoʻonohonoho kuki.
Inā hoʻopau ʻoe i kēia kuki, ʻaʻole hiki iā mākou ke mālama i kāu mau makemake.ʻO ia ke ʻano o kēlā me kēia manawa āu e kipa ai i kēia pūnaewele pono ʻoe e hoʻā a hoʻopau hou i nā kuki.
Ka manawa hoʻouna: Apr-10-2020