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Loaʻa ka paʻi ma https://www.gov.uk/government/publications/uknhcc-scientific-opinion-white-mulberry-leaf-extract-and-blood-glucose-levels/scientific-opinion-for-the-substantiation .loaʻa-koi-no-ola-ma-hoʻokahi-component-mai-white-mulberry-extract-a-kōkua-healthy-bl
Ua ʻōlelo ka UKNHCC Code of Conduct e hele nā mea nānā kūhelu i nā hālāwai UKNHCC e hāʻawi i ka ʻike hou e pili ana i nā pilikia ʻepekema a me nā kulekele i kēia manawa ma ko lākou mau ʻāina me ka mahalo i ke kūʻokoʻa o ka UKNHCC.
UKNHCC (UK Nutrition and Health Claims Council), 2023 Reserved Scientific Opinion (EC) No 1924/2006, Nutritional Regulations (Amendments etc.) (Leaving the EU) and Nutritional Regulations (Amendments etc.) .) (withdrawal from EU) 2020 e like me ka hoololi.
ʻAʻole kēia manaʻo a ʻaʻole pono e manaʻo ʻia ma ke ʻano he mana kūʻai aku no ka unuhi ʻana i ka lau mulberry, he loiloi maikaʻi o kona palekana, ʻaʻole hoʻi he manaʻo no ka helu ʻia ʻana o ka lau mulberry ma ke ʻano he meaʻai.Pono e hoʻomaopopo ʻia ʻaʻole i hāʻawi ʻia kēia ʻano hoʻoponopono ma lalo o ka Food (Amendment, etc.) (Leaving the EU) Regulation 2019 and the Food Preservation (Amendment) Regulation (EC) No 1924/2006 [footnote 1], etc. .) (Haʻalele i ka EU) Hoʻoponopono 2020
Pono e hoʻokūpaʻa ʻia e hoʻololi ʻia ka laulā, nā huaʻōlelo i manaʻo ʻia o nā koi a me nā kūlana o ka hoʻohana ʻana i manaʻo ʻia e ka mea noi ma mua o ka pau ʻana o ke kaʻina hana hāʻawi i hāʻawi ʻia ma ka Paukū 18(4) o ka Savings Regulation (EC) ʻAʻole 1924/2006 [footnote 1] E like me ka hoʻololi ʻia, e ka Meaʻai (Amendment, etc.) (Haʻalele i ka EU) Regulations 2019 a me ka Food (Amendments, etc.) (Leaving the EU) Regulations 2020.
Ua loaʻa nā noi e UKNHCC ma 5 ʻAukake 2022 a ua hoʻomaka koke ke kaʻina loiloi ʻepekema.
Ma ʻAukake 19, 2022, ua hoʻokuʻu ʻia ka loiloi ʻepekema ma hope o ke kaʻina hana "hoʻopau i ka uaki" e koi ana i nā mea noi e hāʻawi i ka ʻike hou aku.
Ma ka 4 Kepakemapa 2022, ua loaʻa i ka UKNHCC ka ʻike hou aʻe a hoʻomaka hou i ka loiloi ʻepekema e like me ka Paukū 16(1) o ka Regulation (EC) No 1924/2006.
ʻAe ʻia e hana i nā koi olakino ma lalo o ka Paukū 14(1)(a) Surviving Regulation (EC) No 1924/20061 e like me ka hoʻololi ʻia e ka Nutrition (Amendment, etc.) Regulation (withdrawal from the European Union) 2019 a hoʻopuka ʻia e ka mana kūpono o UK .Mana ma ka palapala noi Ascarit UK.Ma ka Nutrition (Amendment, etc.) (Leaving the EU) Regulations 2020, ua noi ʻia ka UK Nutrition and Health Claims Committee (UKNHCC) e ʻōlelo e pili ana i ke kumu ʻepekema no nā koi olakino o nā lau mulberry (M. alba).ʻO nā extracts i "hōʻoia ʻia e kōkua i ka mālama ʻana i ke kō koko koko maikaʻi."
Ua manaʻo ʻia e kau ʻia ka laulā o ka noi i nā koi olakino e pili ana i ka hōʻemi ʻana i ka maʻi maʻi, me kahi noi no ka pale pilikino, a ua hoʻihoʻi ʻia ma hope.
ʻO ka meaʻai meaʻai i ʻōlelo ʻia he olakino, he ʻāpana hoʻokahi ia o ka lau M. alba (keʻokeʻo mulberry).
I ka manaʻo o ke Kōmike, ʻaʻole lawa ke ʻano o ka meaʻai o ka lau M. alba no nā koi i manaʻo ʻia.
ʻO ka ʻōlelo a ka mea noi, ʻo ia ka ʻāpana lau M. alba i "hōʻoia ʻia e kōkua i ka mālama ʻana i ke kō koko koko maikaʻi."ʻO ke kumu pilikia i hoʻopaʻa ʻia ʻo ia ka hoʻokiʻekiʻe ʻana i ke kō koko a ʻo ka maʻi maʻi pili i ka maʻi diabetes type 2.ʻO ka hui i manaʻo ʻia he "maʻi me ka maʻi diabetes type 2".ʻO ia mau hopena i hoʻopiʻi ʻia ma waho o ke kiko o ka Paukū 14(1)(a) nā koi olakino.E like me ka wehewehe ʻana ma ka Paukū 2(6) o Regulation (EC) No 1924/2006, ʻo ka "koi hōʻemi i ka maʻi maʻi" ʻo ia kekahi koi olakino e ʻōlelo ana, paipai a hōʻike paha i ka ʻai ʻana i kahi ʻano meaʻai, meaʻai a i ʻole kekahi o kāna mau mea.Hoʻemi nui ʻia nā kumu pilikia no ka ulu ʻana o nā maʻi kanaka.Wahi a ka Diet, Nutrition and Allergy (NDA) Panel o ka European Food Safety Authority (EFSA), ke manaʻo nei ke Komisina e pili ana nā koi olakino i ka lehulehu (olakino).Ua noʻonoʻo pū ke Kōmike inā pili ka hoʻopiʻi olakino i kahi hana a i ʻole ka hopena e pili ana i kahi maʻi, ʻaʻole ʻo ka poʻe me ka maʻi ka heluna kanaka i manaʻo ʻia no ka koi (EFSA, 2021).
ʻAʻole ʻike ke Kōmike i ke ʻano i hoʻohana ʻia i ka loiloi puke i waiho ʻia e ka mea noi a no laila ʻaʻole hiki ke loiloi inā ua waiho ʻia nā hōʻike āpau no ka noʻonoʻo ʻana.Ua ʻike ka mea noi i ka huina o 13 mau paʻi i manaʻoʻiʻo e pili ana i nā koi, me:
ʻO nā hōʻike i hāʻawiʻia e ka mea noi, 2 RCTs (Lown et al. 2017; Thondre et al. 2021)ʻaʻole i loiloi i nā hōʻike e kākoʻo ana i kēia koi.ʻO ka hoʻāʻo ʻana i hoʻopaʻa ʻia (Mudra et al., 2007) he hōʻike hōʻuluʻulu a manaʻo ʻia he kiʻekiʻe kiʻekiʻe o ka manaʻo.ʻAʻole i loiloi kahi noiʻi ʻole ʻia (Chatterji a me Fogel, 2018) i nā hōʻike e kākoʻo i kēia koi.ʻElima mau puke (Bensky, 1993; Asano et al., 2001; Saudek et al., 2008; Gomyo et al., 2004; NIH, 2008) ʻaʻole i hōʻike i nā huahana meaʻai a / a i ʻole nā hopena i koi ʻia.ʻEkolu mau puke (Lown, 2017; Drugs.com, 2022; Gordon-Seymour, 2021) he mau puke ʻepekema ʻole.ʻO kekahi paʻi (Thaipitakwong et al., 2018) he ʻatikala loiloi e pili ana i nā lau mulberry a me kā lākou hopena i ka hopena cardiometabolic.I ka manaʻo o ke Kōmike, ʻaʻole hiki ke unuhi ʻia mai kēia mau puke e kākoʻo i kēia ʻōlelo.
Ma muli o ka ʻike i hāʻawi ʻia, ua hoʻoholo ke Kōmike ʻaʻole hiki ke hoʻokumu ʻia kahi pilina kumu ma waena o ka ʻai ʻana i ka lau M. alba a me nā hopena i koi ʻia.Ua hoʻoholo pū ke komite ʻaʻole i hāʻawi ʻia kahi hōʻike no kahi hui ma waena o nā hopena i koi ʻia a me ka pilikia o ka hoʻomohala ʻana i ka maʻi diabetes type 2.
Aia i loko o ka palapala noi kahi noi no ka pale ʻana i ka ʻikepili huna, a ua hoʻihoʻi ʻia ma hope.
ʻO ka meaʻai i loaʻa i ke kuleana olakino ʻo M. alba (mulberry keʻokeʻo), ʻo ia ka 50% o ka ʻiʻo roundworm.
ʻO ka loaʻa ʻana o ka mulberry i hōʻemi nui i ka nui o ka glucose mai ka pae mana i kahi pae haʻahaʻa a hoʻonui nui i ka pae o ka insulin i hoʻohālikelike ʻia i ka pae mana.I loko o kahi noiʻi lapaʻau, ua hoʻāʻo ʻia nā roundworms no ko lākou hiki ke hoʻohaʻahaʻa i nā pae glucose.Ua mālama ʻia kahi haʻawina hoʻopaʻa ʻana i ke kikowaena hoʻokahi ma ka ʻIseraʻela.
Manaʻo ka mea noi i kēia mau huaʻōlelo o ka pono olakino: "Ua hōʻoia ʻia i ke kino e kōkua i ka mālama ʻana i ke kō koko koko maikaʻi."
ʻAʻole i hāʻawi ka mea noi i nā kūlana kūikawā no ka hoʻohana ʻana i ka meaʻai M. alba ke kumuhana o ka haʻi.Hāʻawi ʻia nā ʻōlelo hoʻohana i manaʻo ʻia no ka hoʻohui Ascarit.ʻO ka hui i manaʻo ʻia he poʻe maʻi me ka maʻi diabetes type 2.
Ma muli o ka Paukū 14(1)(a) o Regulation (EC) No 1924/2006 [footnote 1] Hoʻololi ʻia e ka ʻōlelo ʻai meaʻai (hoʻololi) e pili ana i nā koi olakino o ka ʻili lau mulberry a me ka mālama ʻana i nā pae koko koko olakino, etc. d.) (EU Rejection) Hoʻoponopono 2019 a me nā Hoʻoponopono Meaʻai (Hoʻololi, etc.) (Haʻalele i ka EU) Hoʻoponopono 2020 ID noi: 002UKNHCC.Hāʻawi ʻia e Ascarit UK.
1.1 Ma ka pane ʻana i kahi noi UKNHCC no ka wehewehe ʻana i ka huahana meaʻai i ke kumuhana o ke koi olakino, ua hōʻoia ka mea noi i ka huahana meaʻai he extract o M. alba (lau mulberry keʻokeʻo).ʻAʻole i hāʻawi mai ka mea noi i nā kikoʻī e pili ana i ka haku mele ʻana, nā ʻano like ʻole o ka pūʻulu a i ʻole nā haʻawina kūpaʻa o ka M. alba leaf extract.
1.2 Hāʻawi ka mea noi i kahi ʻike o ke kaʻina hana Ascarite i wehewehe ʻia ma ke ʻano he mea hoʻohui multi-component i loaʻa:
Hoʻomaʻemaʻe ʻia nā lau a me nā pua a hoʻomaʻemaʻe hou ʻia (ʻo ia hoʻi ka paʻa ʻana i ko lākou kala mua, ke ʻano, a me ka pehu ʻana) ma o ka hui ʻana o ka ʻokiʻoki, kaomi ʻana, a me ka hoʻoneʻe ʻana i ka wela me ka brewing e hoʻonui i ka hoʻihoʻi ʻana o nā mea kanu, me ka lau latex.Ma hope o kēlā, hoʻomaʻalili koke ka wai i 20-30 degere Celsius, a laila kānana.Hoʻomaʻemaʻe ʻia nā ʻāpana aʻa a me ka ʻili, a laila hana ʻia me ka hoʻohana ʻana i ka wela a me ka hoʻoilo.Aia i loko o ka hopena i hui ʻia (e like me ka pākēneka o ke kaumaha o ka nui o ka hopena) 50% Morus, 20% Artemisia, 10% Urtica, 10% Cinnamon a me 10% Taraxacum.
Ua noi ka mea noi e hoʻopaʻa ʻia ke ʻano waiwai o ka haku mele a me ka hana hana ʻana o Ascarit, akā ma hope ua hoʻihoʻi i kēia koi.
1.3 Ma ka manao o ke Komite, aole i lawa pono ke ano o ka mea ai o na lau o M. alba, oia ke kumuhana o ke ola kino, e pili ana i ka hopena o ke koi i manaoia.
2.1 Ua ʻōlelo ka mea noi ʻo ka maʻi maʻi type 2 he maʻi metabolic i hōʻike ʻia e ke kiʻekiʻe o ka glucose koko.I ka pane ʻana i kahi noi UKNHCC no nā hōʻike e hōʻike ana i ka pilina ma waena o kahi kumu pilikia (kiʻekiʻe ke koko glucose) a me ka pilikia o kahi maʻi pili (type 2 diabetes), ua hāʻawi ka mea noi i nā haʻawina 3 (DCCT, 1995; Rohlfing et al., 2002). Sveta, 2014).ʻO ka hui noiʻi Diabetes Control and Complications Trial (DCCT) (1995) a me Rolfing et al.(2002) hōʻike i nā DCCT me nā poʻe maʻi me ka maʻi diabetes-pili i ka insulin (type 1) akā ʻaʻole me ka maʻi diabetes type 2.ʻano (maʻi e pono ai ka hoʻemi ʻana i ka pilikia).).Ua helu ʻo Swetha (2014) i ka pilina ma waena o HbA1c (glycosylated hemoglobin) a me nā hopena like ʻole (ka hoʻokē ʻai, postprandial a me ka hoʻomaha glucose) e loiloi i ko lākou pono no ka nānā ʻana i ka mana glycemic i nā maʻi maʻi maʻi.I ka manaʻo o ke komite, ʻaʻole i hāʻawi nā mea noi i nā hōʻike o ka pilina kumu ma waena o ke kiʻekiʻe o ka glucose koko kiʻekiʻe a me ka pilikia o ka hoʻomohala ʻana i ka maʻi maʻi type 2, a i ʻole he mea wānana kūʻokoʻa ke kiʻekiʻe o ka glucose koko kiʻekiʻe o ka maʻi diabetes type 2.
2.2 Hāʻawi ka mea noi i kekahi mau ʻike hou e pane ai i kahi noi UKNHCC no ka ʻike e pili ana i ka hopena, nā hopena hopena a me nā hana i manaʻo ʻia no ka loiloi ʻana i nā kumu pilikia i nā haʻawina kanaka.Eia naʻe, ma muli o ka ʻike i hāʻawi ʻia, ʻaʻole maopopo i ke Kōmike nā hopena a nā mea noi e noi nei a pehea e loiloi ʻia ai lākou.
2.3 ʻO ka hopena i ʻōlelo ʻia e ka mea noi "ua hōʻoia ʻia e kōkua i ka mālama ʻana i ke kō koko koko maikaʻi".ʻO ka pūʻulu i manaʻo ʻia e ka mea noi he mau maʻi me ka maʻi diabetes type 2.
2.4 Hoʻomaopopo ke Kōmike ʻaʻole pili ka hui i manaʻo ʻia o nā maʻi me ka maʻi diabetes type 2 i nā koi olakino ma lalo o ka Paukū 14(1)(a) o ka Regulation (EC) No 1924/2006.E like me ka wehewehe ʻana ma ka Paukū 2(6) o Regulation (EC) No 1924/2006, ʻo ka "koi hōʻemi i ka maʻi maʻi" ʻo ia kekahi koi olakino e ʻōlelo ana, paipai a hōʻike paha i ka ʻai ʻana i kahi ʻano meaʻai, meaʻai a i ʻole kekahi o kāna mau mea.Hoʻemi nui ʻia nā kumu pilikia no ka ulu ʻana o nā maʻi kanaka.Wahi a ka Diet, Nutrition and Allergy (NDA) Panel o ka European Food Safety Authority (EFSA), ke manaʻo nei ke Komisina e pili ana nā koi olakino i ka lehulehu (olakino).Ua noʻonoʻo pū ke Kōmike inā pili ka hoʻopiʻi olakino i kahi hana a i ʻole ka hopena e pili ana i kahi maʻi, ʻaʻole ʻo ka poʻe me ka maʻi ka heluna kanaka i manaʻo ʻia no ka koi (EFSA, 2021).
2.5 No ka hoʻokō ʻana i ka hopena i koi ʻia, ʻōlelo ka mea noi e lawe i 2 mau capsule roundworm me ka wai 30 mau minuke ma mua o ka ʻai ʻana 3 manawa i ka lā.ʻAʻole ʻōlelo ka poʻe noi i ka noʻonoʻo, dosage a i ʻole ka lōʻihi o ka hoʻohana ʻana.
2.6 Ua ʻike ke Kōmike he mea maikaʻi paha ka hoʻemi ʻana i ka pane glycemic postprandial no ka poʻe i loaʻa mua i ka hoʻomanawanui ʻana i ka glucose, akā ua manaʻo ke Kōmike ʻaʻole i hoʻokō nā huaʻōlelo i manaʻo ʻia i nā pae no ka noʻonoʻo ʻana ma ka Paukū 14(1)(a) , ʻaʻole hoʻi i hana i nā ʻōlelo e pili ana i nā pōmaikaʻi olakino Nā pae hoʻohālikelike e kūʻē i nā koi no ka hōʻemi ʻana i ka pilikia o ka maʻi.
3.1 Ke noi ʻia e ka UKNHCC, noi ʻia nā mea noi e hāʻawi i nā kikoʻī o ka loiloi puke, e pili ana i ka mea kākau, nā pahuhopu, nā koina kūpono, ka hoʻolālā ʻimi piha a me kēlā me kēia ʻikepili i ʻimi ʻia.Ua kaupalena ʻia ka ʻike i hāʻawi ʻia i hiki ʻole i ke Kōmike ke loiloi inā ua waiho ʻia nā hōʻike a pau no ka noʻonoʻo ʻana.
3.2 Ua hōʻike ka mea noi i ka huina o 13 mau puke i manaʻoʻiʻo e pili ana i nā koi, me:
Manaʻo ke Kōmike ʻaʻole hiki ke unuhi ʻia nā manaʻo mai kēia mau puke no ka mea ʻaʻohe hōʻike hōʻoia e kākoʻo i kēia ʻōlelo.
3.4 Loaʻa i kahi loulou i kahi puke e pili ana i ka lāʻau lapaʻau Kina (Bensky, 1993).ʻAʻohe ʻike mokuna, helu ʻaoʻao, a me nā ʻāpana o ka puke i waiho ʻia i ke komite no ka noʻonoʻo ʻana, no laila ʻaʻole hiki ke helu ʻia.
3.5 Hōʻuluʻulu ka pepa ʻoiaʻiʻo (NIH, 2008) i nā haʻawina e pili ana i ka mālama ʻana i ka maʻi diabetes a me nā pilikia a me nā haʻawina hope, akā ʻaʻole loiloi i nā hōʻike e kākoʻo ana i kēia ʻōlelo, no laila ʻaʻole hiki ke unuhi ʻia mai kēia puke.
ʻO kahi haʻawina hoʻokolohua (Asano et al., 2001) i wehewehe i ka hoʻokuʻu ʻana o M. alba alkaloids a me kā lākou hopena pale i nā glycosidases, akā ʻaʻole i loiloi ʻia nā hōʻike e kākoʻo i kēia koi.Manaʻo ke Kōmike ʻaʻole hiki ke unuhi ʻia nā hopena mai kēia mau puke.
3.7 I loko o ʻekolu RCTs (Lown et al., 2017; Thondre et al., 2021; Mudra et al., 2007), ua hoʻonohonoho ʻia nā mea komo e loaʻa i ka lau mulberry extract.Lown et al.(2017) a me Thondre et al.(2021) he papalua makapō, randomized, hana hou, crossover ho'āʻo loiloi 'ana i ka hoʻohana 'ole ka hoʻohana 'ana i ka proprietary mulberry lau extract (Reducose®) versus placebo i loko o nā kumuhana ola 'glycemic pane i ka carbohydrate pilikia.I ka manaʻo o ke Kōmike, ʻaʻole hiki ke unuhi ʻia nā hopena mai kēia mau puke no ka mea ʻaʻole lākou i loiloi i nā hōʻike e kākoʻo ana i kēia koi.ʻO Mudra et al.(2007) he hōʻike hōʻuluʻulu e hōʻuluʻulu ana i kahi noiʻi crossover randomized i loiloi i ka hopena o ka lau mulberry a i ʻole placebo i ka pane ʻana o ka glucose koko o nā poʻe olakino olakino (10 mau mea komo) a me nā maʻi me ka maʻi diabetes type 2 (10 poʻe).Ua noʻonoʻo ke Kōmike he pilikia nui paha ka haʻawina ma muli o ka nele o ka ʻike e pili ana i ke kaʻina hana randomization, hiki ke hoʻopili ʻia me ka hana i manaʻo ʻia, a me ke ʻano o ke koho ʻana i nā hopena i hōʻike ʻia.
3.8 ʻO kahi haʻawina hoʻopaʻa ʻole ʻia (Chatterji a me Fogel, 2018) i loaʻa i nā maʻi me ka maʻi diabetes type 2.Ua loiloi ʻo Chatterji a me Fogel (2018) i ka hopena o ka mea kanu lāʻau SR2004 (ʻo ia hoʻi nā lau M. alba, nā lau U. dioica, ka ʻili kinamona, nā ʻāpana lau A. dracunculus a me nā ʻāpana aʻa T. officinale) ma nā pae HbA1c hoʻokahi manawa i ka pule no nā lā 12. .pule a laila ma 24 pule.I ka manaʻo o ke Kōmike, ʻaʻohe hopena e hiki ke huki ʻia mai kēia haʻawina hoʻomalu ʻole, ʻaʻole i loiloi i nā hōʻike e kākoʻo ana i nā koi.
3.9 No laila ke noʻonoʻo nei ke Kōmike ʻaʻole hiki ke unuhi ʻia nā manaʻo mai nā hōʻike i hōʻike ʻia e ka mea hoʻopiʻi i ka hopena o ka unuhi ʻana o ka lau albaflora i ka pae koko glucose.
4.1 I ka loiloi ʻana i nā hōʻike, ua noʻonoʻo ke kōmike i ka 1 randomized controlled trial (Mudra et al., 2007) i hiki ke huki ʻia nā hopena.
4.2 Ua hoʻoholo ke Kōmike, ma muli o nā hōʻike i hōʻike ʻia, ʻaʻole hiki ke hoʻokumu i kahi pilina kumu ma waena o ka ʻai ʻana i ka lau Albiflora a me nā hopena i koi ʻia.Ua hoʻoholo pū ke komite ʻaʻole i hāʻawi ʻia kahi hōʻike no kahi hui ma waena o nā hopena i koi ʻia a me ka pilikia o ka hoʻomohala ʻana i ka maʻi diabetes type 2.
Morus Alba (Muscus alba) Leaf Extract ʻAʻole i hōʻike pono ʻia ke kumuhana o nā koi olakino i manaʻo ʻia e pili ana i nā hopena o nā koi.
ʻAʻole kūpono nā koi no nā maʻi me ka maʻi diabetes type 2 i nā koina i hoʻonohonoho ʻia ma Regulation (EC) No 1924/2006.e like me ka Pauku 14(1)(a).
ʻAʻole hiki ke hoʻokumu ʻia kahi pilina kumu ma waena o ka ʻai ʻana i ka lau mulberry a me nā hopena i koi ʻia, a ʻaʻohe hōʻike o ka pilina ma waena o nā hopena i koi ʻia a me ka pilikia o ka hoʻomohala ʻana i ka maʻi diabetes type 2.
Ka manawa hoʻouna: Jan-29-2023