Hesperidin Methyl Chalcone 98% by UV: Comprehensive Product Description
1. Introduction to Hesperidin Methyl Chalcone (HMC)
Hesperidin Methyl Chalcone (HMC) is a methylated derivative of hesperidin, a flavonoid naturally abundant in citrus fruits such as oranges, lemons, and grapefruits . With a UV-determined purity of ≥98%, this compound is widely recognized for its multifaceted benefits in vascular health, skincare, and antioxidant protection . Its molecular formula is C29H36O15 (molecular weight: 624.59 g/mol), and it is characterized by a bright yellow to orange crystalline powder that is highly hygroscopic and soluble in water, ethanol, and methanol .
2. Product Specifications
- CAS Number: 24292-52-2
- Purity: ≥98% by UV analysis
- Appearance: Yellow to orange crystalline powder
- Solubility:Storage: Store in a cool, dry place (2–8°C) away from light and moisture. Shelf life: 2 years .
- Freely soluble in water, ethanol, and methanol.
- Partially soluble in ethyl acetate .
- Packaging: 25 kg/drum (double-layered polyethylene bags inside cardboard barrels) .
3. Key Benefits and Mechanisms of Action
3.1 Vascular and Circulatory Health
HMC strengthens capillaries by reducing permeability and enhancing venous tone, making it effective for treating conditions like chronic venous insufficiency, hemorrhoids, and varicose veins . Clinical studies highlight its synergy with Ruscus aculeatus extract and ascorbic acid, which collectively improve microcirculation and reduce edema .
3.2 Skincare and Dermatological Applications
- Anti-Redness and Dark Circle Reduction: HMC decreases capillary leakage under the eyes, reducing bluish discoloration and puffiness. It is a key ingredient in premium eye creams (e.g., MD Skincare Lift Lighten Eye Cream, Provectin Plus Advanced Eye Cream) .
- UV Protection and Anti-Aging: HMC neutralizes UVB-induced oxidative stress, inhibits MMP-9 (a collagen-degrading enzyme), and stimulates filaggrin production to enhance skin barrier function .
- Anti-Inflammatory and Antioxidant Effects: By suppressing NF-κB and IL-6 pathways, HMC mitigates inflammation and oxidative damage linked to acne, rosacea, and photoaging .
3.3 Broad-Spectrum Antioxidant Activity
HMC activates the Nrf2 signaling pathway, boosting endogenous antioxidants like glutathione and superoxide dismutase. This mechanism protects against UV radiation, pollution, and metabolic stressors .
4. Applications in Formulations
4.1 Nutraceuticals
- Dosage: 30–100 mg/day in capsules or tablets for venous support .
- Combination Formulas: Often paired with Diosmin, Ascorbic Acid, or Ruscus Extract for enhanced bioavailability and efficacy .
4.2 Cosmetics and Topicals
- Concentration: 0.5–3% in serums, creams, and gels .
- Key Formulations:
- Anti-Redness Serums: Reduces facial erythema and sensitivity.
- Eye Contour Products: Targets dark circles and puffiness (e.g., Kool Eye Gel with menthol for cooling effects) .
- Sun Care Products: Acts as a UV filter (absorption peak at ~284 nm) and stabilizes Avobenzone in sunscreens .
5. Quality Assurance and Safety
- Purity Testing: Complies with pharmacopeial standards using HPLC and IR spectroscopy .
- Safety Profile:Regulatory Status: Meets EU and US FDA guidelines for dietary supplements and cosmetics .
- Non-irritating at recommended doses (LD50 > 2000 mg/kg in rodents).
- No reported mutagenicity or reproductive toxicity .
6. Market Advantages
- High Bioavailability: Superior absorption compared to native hesperidin .
- Multifunctionality: Addresses both health and aesthetic concerns (e.g., vascular health + anti-aging).
- Clinical Backing: Over 20 peer-reviewed studies validate its efficacy in vascular protection, UV resistance, and inflammation control .
7. Ordering and Customization
- MOQ: 25 kg/drum (custom packaging available).
- Documentation: COA, MSDS, and stability data provided upon request .
- OEM Services: Tailored formulations for nutraceuticals, cosmetics, or pharmaceuticals.
8. Conclusion
Hesperidin Methyl Chalcone 98% by UV is a premium, science-backed ingredient with proven benefits for vascular integrity, skin health, and oxidative defense. Its versatility in formulations—from eye creams to venous supplements—makes it a strategic choice for brands targeting health-conscious and beauty-focused markets.
