Xyoo 1913, Swedish kws tshawb fawb xibfwb Kylin nrhiav pom cov nplaum nplaum nplaum ntawm kelp, fucoidan, ntawm Uppsala University.Kuj hu ua "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", thiab lwm yam, lus Askiv lub npe yog "Fucoidan".Nws yog cov dej-soluble polysaccharide cov khoom uas muaj fucose uas muaj sulfate pawg.Nws yog tsuas yog tam sim no nyob rau hauv lub nto slime ntawm xim av algae (xws li seaweed, wakame spores, thiab kelp).Cov ntsiab lus yog kwv yees li 0.1%, thiab cov ntsiab lus hauv kelp qhuav yog li 1%.Nws yog ib qho tseem ceeb heev seaweed active tshuaj.
Ua ntej, qhov ua tau zoo ntawm fucodan
Tam sim no Nyiv yog lub teb chaws nrog lub neej ntev tshaj plaws hauv ntiaj teb.Nyob rau tib lub sijhawm, Nyiv muaj ib qho ntawm cov kab mob qis tshaj plaws.Raws li cov kws paub txog zaub mov, ib qho ntawm cov laj thawj tseem ceeb tshaj plaws rau kev noj qab haus huv ntawm cov neeg Nyij Pooj tuaj yeem cuam tshuam nrog kev noj cov seaweed tsis tu ncua.Fucoidan muaj nyob rau hauv xim av algae xws li kelp yog ib yam khoom uas muaj ntau yam physiological functions.Txawm hais tias nws tau tshawb pom los ntawm Xib Fwb Kylin hauv xyoo 1913, nws tsis yog txog xyoo 1996 uas Fucoidan tau luam tawm ntawm 55th Japanese Cancer Society Conference.Daim ntawv tshaj tawm tias "tuaj yeem ua rau mob qog noj ntshav apoptosis" tau ua rau muaj kev txhawj xeeb thoob plaws hauv zej zog kev kawm thiab ua rau muaj kev loj hlob hauv kev tshawb fawb.
Tam sim no, lub zej zog kev kho mob tab tom tshawb fawb txog ntau yam kev ua haujlwm lom neeg ntawm fucoidan, thiab tau luam tawm ntau txhiab daim ntawv hauv cov ntawv kho mob thoob ntiaj teb, lees paub tias fucoidan muaj ntau yam kev ua haujlwm lom neeg, xws li tshuaj tiv thaiv qog, txhim kho plab hnyuv, thiab antioxidant, txhim kho kev tiv thaiv kab mob. , antithrombotic, txo cov ntshav siab, tshuaj tiv thaiv kab mob.
(I) Fucoidan txhim kho txoj hnyuv plab
Helicobacter pylori yog helical, microaerobic, gram-negative bacilli uas xav tau heev ntawm kev loj hlob.Nws yog tib hom kab mob microbial tam sim no paub tias muaj sia nyob hauv tib neeg lub plab.Helicobacter pylori kab mob ua rau gastritis thiab digestive ib ntsuj av.Cov kab mob hauv lub plab, lymphoproliferative gastric lymphomas, thiab lwm yam, muaj qhov tsis zoo rau kev mob qog noj ntshav.
Cov txheej txheem pathogenic ntawm H. pylori muaj xws li: (1) adhesion: H. pylori tuaj yeem dhau los ua ib qho hnoos qeev thiab ua raws li lub plab epithelial hlwb;(2) neutralize gastric acid rau cov txiaj ntsig ntawm kev ciaj sia: H. pylori tso urease, thiab Urea hauv plab reacts los tsim cov roj ammonia, uas neutralizes gastric acid;(3) rhuav tshem lub plab mucosa: Helicobacter pylori tso VacA cov tshuaj lom thiab erodes cov hlwb ntawm lub plab mucosa;(4) tsim cov tshuaj lom chloramine: ammonia roj ncaj qha erodes gastric mucosa, thiab reactive oxygen Cov tshuaj tiv thaiv ua rau cov tshuaj chloramine ntau dua;(5) Ua rau muaj kev mob tshwm sim: Txhawm rau tiv thaiv Helicobacter pylori, ntau cov qe ntshav dawb sib sau ua ke ntawm lub plab mucosa los tsim cov lus teb inflammatory.
Cov teebmeem ntawm fucodan tiv thaiv Helicobacter pylori muaj xws li:
1. Inhibition ntawm Helicobacter pylori proliferation;
Xyoo 2014, pawg tshawb fawb Yun-Bae Kim ntawm Chungbuk National University hauv Kaus Lim Qab Teb tau tshaj tawm txoj kev tshawb fawb qhia tias fucoidan muaj cov kab mob tua kab mob zoo heev, thiab fucoidan ntawm qhov concentration ntawm 100µg / mL tuaj yeem cuam tshuam tag nrho kev loj hlob ntawm H. pylori.(Lab Anim Res2014: 30 (1), 28–34.)
2. Tiv thaiv qhov adhesion thiab ntxeem tau ntawm Helicobacter pylori;
Fucoidan muaj cov pab pawg sulfate thiab tuaj yeem khi rau Helicobacter pylori los tiv thaiv nws los ntawm kev ua raws li lub plab epithelial hlwb.Nyob rau tib lub sijhawm, Fucoidan tuaj yeem cuam tshuam urease ntau lawm thiab tiv thaiv acidic ib puag ncig ntawm lub plab.
3. Antioxidant nyhuv, txo cov tshuaj lom ntau lawm;
Fucoidan yog ib qho antioxidant zoo, uas tuaj yeem tshem tawm cov pa dawb radicals sai sai thiab txo qis kev tsim cov tshuaj lom chloramine.
4. Anti-inflammatory nyhuv.
Fucoidan tuaj yeem cuam tshuam cov kev ua haujlwm ntawm kev xaiv lectin, ntxiv thiab heparanase, thiab txo cov lus teb inflammatory.(Helicobacter, 2015, 20, 89–97.)
Tsis tas li ntawd, cov kws tshawb fawb pom tau tias fucoidan muaj txiaj ntsig zoo rau kev txhim kho txoj hnyuv thiab muaj ob txoj hauv kev ua rau cov hnyuv: txhim kho cem quav thiab enteritis.
Hauv 2017, pab pawg tshawb fawb los ntawm xibfwb Ryuji Takeda ntawm Kansai University of Welfare Sciences hauv Nyij Pooj tau tshawb fawb.Lawv xaiv 30 tus neeg mob cem quav thiab muab faib ua ob pawg.Cov pab pawg sim tau muab 1 g ntawm fucoidan thiab pawg tswj hwm tau muab cov placebo.Ob lub hlis tom qab qhov kev sim, nws tau pom tias tus naj npawb ntawm defecation nyob rau ib lub lim tiam nyob rau hauv lub xeem pab pawg neeg noj fucoidan nce los ntawm qhov nruab nrab ntawm 2.7 hnub mus rau 4.6 hnub, thiab lub defecation ntim thiab softness tau nce ntau.(Functional Foods in Health and Disease 2017, 7:735-742.)
Nyob rau hauv 2015, ib pab neeg ntawm Xib Fwb Nuri Gueven ntawm University of Tasmania, Australia, pom tias fucoidan tuaj yeem txhim kho enteritis hauv nas, ntawm ib sab, nws tuaj yeem pab cov nas rov qab hnyav thiab nce qhov tawv nqaij ntawm qhov quav;ntawm qhov tod tes, nws tuaj yeem txo qhov hnyav ntawm txoj hnyuv thiab tus po.Txo qhov mob ntawm lub cev.(PLoS ONE 2015, 10: e0128453.)
B) Antitumor nyhuv ntawm fucoidan
Kev tshawb fawb ntawm cov nyhuv antitumor ntawm fucoidan yog tam sim no muaj kev txhawj xeeb tshaj plaws los ntawm kev kawm lub voj voog, thiab ntau qhov kev tshawb fawb tau txais.
1. Kev tswj cov qog cell voj voog
Xyoo 2015, Xib Fwb Lee Sang Hun thiab lwm tus ntawm Soonchunhyang University hauv South Kauslim thiab lwm cov kws tshawb fawb pom tias fucoidan inhibits kev qhia ntawm cyclin Cyclin thiab cyclin kinase CDK hauv cov qog hlwb los ntawm kev tswj lub voj voog loj hlob ntawm tib neeg cov kab mob qog noj ntshav, cuam tshuam rau cov mitosis ib txwm muaj. qog hlwb.Stagnate qog hlwb nyob rau hauv pre-mitotic theem thiab inhibit qog cell proliferation.(Molecular Medicine Reports, 2015, 12, 3446.)
2.Induction ntawm qog cell apoptosis
Hauv xyoo 2012, kev tshawb fawb luam tawm los ntawm Quan Li pab pawg tshawb fawb ntawm Qingdao University pom tias fucoidan tuaj yeem qhib lub teeb liab apoptosis ntawm cov qog hlwb-Bax apoptosis protein, ua rau DNA puas rau cov qog nqaij hlav cancer mis, chromosome aggregation, thiab induce spontaneous apoptosis ntawm qog hlwb., Inhibited kev loj hlob ntawm qog hlwb nyob rau hauv nas.(Plos One, 2012, 7, e43483.)
3.Inhibit qog cell metastasis
Hauv xyoo 2015, Chang-Jer Wu thiab lwm tus kws tshawb fawb los ntawm National Taiwan Ocean University tau luam tawm kev tshawb fawb qhia tias fucoidan tuaj yeem ua rau cov nqaij mos inhibitory (TIMP) qhia thiab txo qis kev tswj hwm matrix metalloproteinase (MMP) qhia, yog li inhibiting qog cell metastasis.(Lub Peb Hlis Ntuj 2015, 13, 1882.)
4.Inhibit qog angiogenesis
Hauv xyoo 2015, pab pawg tshawb fawb Tz-Chong Chou ntawm Taiwan Medical Center pom tias fucoidan tuaj yeem txo qhov tsim ntawm vascular endothelial kev loj hlob zoo (VEGF), inhibit qhov neovascularization ntawm cov qog, txiav tawm cov khoom noj khoom haus ntawm cov qog, tshaib plab rau cov qog. Qhov loj tshaj plaws Thaiv kev sib kis thiab metastasis ntawm cov qog hlwb.(Lub Peb Hlis Ntuj 2015, 13, 4436.)
5. Ua kom lub cev tiv thaiv kab mob
Xyoo 2006, xibfwb Takahisa Nakano ntawm Kitasatouniversity University hauv Nyij Pooj tau tshawb pom tias fucodan tuaj yeem txhim kho lub cev tiv thaiv kab mob thiab siv tus neeg mob lub cev tiv thaiv kab mob tshwj xeeb los tua cov qog nqaij hlav cancer.Tom qab fucoidan nkag mus rau hauv txoj hnyuv, nws tuaj yeem lees paub los ntawm lub cev tiv thaiv kab mob, tsim cov teeb liab uas ua rau lub cev tsis muaj zog, thiab ua kom NK hlwb, B hlwb, thiab T hlwb, yog li tsim cov tshuaj tiv thaiv kab mob uas khi rau cov qog nqaij hlav cancer thiab T hlwb uas tua cov qog noj ntshav. hlwb.Tshwj xeeb tua cov qog nqaij hlav cancer, inhibiting qog nqaij hlav qog noj ntshav.(Planta Medica, 2006, 72, 1415.)
Kev tsim tawm ntawm Fucoidan
Cov ntsiab lus ntawm sulfate pawg nyob rau hauv cov qauv molecular ntawm fucoidan yog ib qho tseem ceeb qhia uas txiav txim siab nws physiological kev ua si, thiab nws kuj yog ib qho tseem ceeb cov ntsiab lus ntawm cov qauv-kev sib raug zoo ntawm fucoidan.Yog li ntawd, cov ntsiab lus ntawm sulfate pawg yog ib qho tseem ceeb parameter rau kev ntsuam xyuas fucoidan zoo thiab cov qauv-kev sib raug zoo.
Tsis ntev los no, daim ntawv tso cai tsim khoom noj fucoidan polysaccharide thaum kawg tau lees paub los ntawm Food and Drug Administration thiab muab rau Qingdao Mingyue Seaweed Group, uas txhais tau hais tias Mingyue Seaweed Group tau cog qoob loo hauv hiav txwv ntau tshaj 50 xyoo.Tau txais daim ntawv pov thawj raug cai.Nws tau tshaj tawm tias Mingyue Seaweed Group tau tsim cov kab ntau lawm fucoidan nrog cov khoom tsim tawm txhua xyoo ntawm 10 tons.Nyob rau hauv lub neej yav tom ntej, nws yuav muab tag nrho kev ua si rau nws "tshuaj thiab zaub mov homology" nyhuv thiab ci ntsa iab nyob rau hauv lub functional zaub mov teb ntawm lub loj kev lag luam.
Mingyue Seaweed Group, raws li kev lag luam pom zoo rau kev tsim cov khoom noj fucoidan, muaj ntau xyoo ntawm kev tsim khoom.Lub fucoidan uas ua los ntawm nws yog ib qho kev txhim kho cov khoom ntawm thawj kelp concentrate / hmoov.Siv cov khoom noj zoo-qib xim av algae ua raw khoom, ntxiv purification thiab sib cais raws li ntuj extraction technology, tsis tsuas yog txhim kho cov tsw thiab saj ntawm cov khoom, tab sis kuj tsub kom lub fucoidan polysaccharide cov ntsiab lus (purity), uas yuav siv tau nyob rau hauv ntau yam xws li khoom noj khoom haus thiab khoom noj noj qab haus huv..Nws muaj qhov zoo ntawm cov khoom siab purity thiab cov ntsiab lus siab ntawm cov pab pawg ua haujlwm;Kev tshem tawm cov hlau hnyav, kev nyab xeeb siab;desalination thiab fishiness, saj thiab tsw txhim kho.
Kev siv Fucoidan
Tam sim no, muaj ntau yam khoom fucoidan tsim thiab siv nyob rau hauv Nyiv, Kaus Lim Qab Teb, Tebchaws Asmeskas thiab lwm lub tebchaws, xws li ntxiv cov concentrated fucoidan, fucoidan extract raw capsules, thiab lubricating seaweed super fucoidan.Cov khoom noj muaj txiaj ntsig xws li Seaweed Group's Qingyou Le, Rockweed Treasure, Brown Algae Cog Dej
Nyob rau hauv xyoo tas los no, "Tshaj Tawm Txog Cov Neeg Suav Cov Khoom Noj Khoom Haus thiab Cov Kab Mob Hlwb" qhia tau hais tias cov qauv kev noj haus ntawm cov neeg nyob hauv Suav tau hloov pauv, thiab cov kab mob kis tau nce zuj zus.Cov phiaj xwm kev noj qab haus huv loj nyob rau ntawm "kev kho mob" tau nyiam ntau yam.Siv fucoidan los tsim thiab tsim cov khoom noj muaj txiaj ntsig ntau dua yuav tshawb nrhiav cov txiaj ntsig zoo ntawm fucoidan los muab lub neej thiab kev noj qab haus huv, uas yog qhov tseem ceeb heev rau kev txhim kho "cov tshuaj noj qab haus huv thiab zaub mov homology" kev lag luam kev noj qab haus huv loj.
Khoom Txuas: https://www.trbextract.com/1926.html
Post lub sij hawm: Mar-24-2020