Palmitoylethanolamide(PEA), ib qho peroxisome proliferator-activated receptor alpha (PPAR-�) ligand uas exerts anti-inflammatory, analgesic, thiab neuroprotective ua, rau kev kho mob ntawm neuro- o, tshwj xeeb tshaj yog muaj feem xyuam rau mob ntev, glaucoma thiab ntshav qab zib retinopathy.
- Cov txheej txheem ntawm kev txiav txim ntawm PEA koom nrog nws cov teebmeem ntawm nuclear receptor PPARα (Gabrielsson li al., 2016).
- Nws tseem cuam tshuam nrog mast cells,cannabinoid tus neeg txais kev pab hom 2 (CB2)-zoo li cannabinoid receptors, ATP-sensitive potassium-channels, transient receptor peev (TRP) channels, thiab nuclear factor kappa B (NFkB).
- Nws tuaj yeem cuam tshuam rau endocannabinoid signaling los ntawm kev ua raws li kev sib tw substrate rau endocannabinoid homologue anandamide (N-arachidonoylethanolamine).
Thawj qhov kev soj ntsuam yog nyob rau hauv 1943 los ntawm Coburn li al.Raws li ib feem ntawm txoj kev tshawb fawb txog kev kis mob tau tsom mus rau cov menyuam yaus rheumatic fever, qhov tshwm sim ntawm cov menyuam yaus noj cov zaub mov qis hauv qe.
- Cov neeg tshawb xyuas no tau sau tseg tias qhov tshwm sim tau txo qis hauv cov menyuam yaus noj cov qe qe hmoov, thiab tom qab ntawd lawv tau pom cov khoom tiv thaiv anaphylactic hauv guinea npua nrog lipid extract los ntawm qe qe.
1957 Kuehl Jr. thiab cov neeg ua hauj lwm tau tshaj tawm tias tau ua tiav hauv kev cais cov crystalline tiv thaiv kab mob los ntawm cov taum pauv.Lawv cais cov compound kuj los ntawm ib feem ntawm phospholipid feem ntawm qe qe thiab los ntawm hexane-extracted txiv laum huab xeeb pluas noj.
- Hydrolysis ntawm PEA ua rau palmitic acid thiab ethanolamine thiab yog li cov compound tau txheeb xyuas raws liN-(2-hydroxyethyl)- palmitamide (Kepple Hesselink li al., 2013).

Flow Chart of Semi-synthesize Palmitoylethanolamide

Mass Spectra (ESI-MS: m / z 300 (M + H +) thiab Nuclear Magnetic Resonance (NMR) ntawm PEA

Food Science & Nutrition DOI 10.1002/fsn3.392

Kev nyab xeeb ntawm micronized palmitoylethanolamide (microPEA): tsis muaj tshuaj lom thiab muaj peev xwm genotoxic

Palmitoylethanolamide (PEA) yog lub ntuj fatty acid amide pom nyob rau hauv ntau yam khoom noj, uas tau xub pom nyob rau hauv lub qe qe.
MicroPEA ntawm cov particle loj (0.5-10μm) raug soj ntsuam rau mutagenicity nyob rau hauvSalmonella typhimurium,rau clastogenicity/aneuploidy nyob rau hauv cultured human lymphocytes, thiab rau mob thiab subchronic nas toxicity nyob rau hauv cov nas, ua raws li tus qauv OECD xeem raws tu qauv, raws li zoo Laboratory Practice (GLP).
PEA tsis tau ua kom muaj kev hloov pauv hauv cov kab mob sib kis uas siv cov kab mob TA1535, TA97a, TA98, TA100, thiab TA102, nrog lossis tsis muaj kev ua kom metabolic, hauv kev sib koom ua ke los yog cov txheej txheem ua kua dej.Ib yam li ntawd, PEA tsis ua rau muaj kev cuam tshuam genotoxic hauv tib neeg lub hlwb kho rau 3 lossis 24 teev yam tsis muaj kev ua haujlwm metabolic, lossis rau 3 teev nrog kev ua haujlwm metabolic.
PEA tau pom tias muaj LD50 ntau dua li qhov txwv ntawm 2000 mg / kg lub cev qhov hnyav (bw), siv OECD Tus Txheej Txheem Qhov ncauj Qhov Ncauj Up thiab Down.Cov koob tshuaj rau 90-hnub nas qhov ncauj toxicity txoj kev tshawb fawb yog raws li cov txiaj ntsig los ntawm kev tshawb fawb ua ntej 14-hnub, uas yog, 250, 500, thiab 1000 mg / kg bw / hnub.
Qib Tsis Muaj Teebmeem (NOEL) hauv ob qhov kev tshawb fawb subchronic yog qhov kev sim tshuaj ntau tshaj.

Br J Clin Pharmacol. Peb Hlis 2016, 82(4): 932-42.

Palmitoylethanolamide rau kev kho mob ntawm qhov mob: pharmacokinetics, kev nyab xeeb thiab kev ua tau zoo

Kaum rau qhov kev sim tshuaj, rau qhov xwm txheej / kev tshawb nrhiav kev sim thiab ib qho kev tshuaj ntsuam xyuas ntawm PEA raws li kev kho mob analgesic tau luam tawm hauv cov ntaub ntawv.
- Rau lub sijhawm kho mob txog li 49 hnub, cov ntaub ntawv kho mob tam sim no tau sib cav tawm tsam cov tshuaj tiv thaiv tsis zoo (ADRs) ntawm qhov xwm txheej ntawm

Rau kev kho mob ntev dua 60 hnub, tus naj npawb ntawm cov neeg mob tsis txaus los txiav txim qhov zaus ntawm ADRs tsawg dua 1/100.
Rau qhov luam tawm randomized soj ntsuam sim yog qhov sib txawv ntawm qhov zoo.Kev nthuav qhia cov ntaub ntawv tsis muaj cov ntaub ntawv ntawm cov ntaub ntawv sib kis thiab tsis qhia cov ntaub ntawv nyob rau lub sij hawm uas tsis yog qhov kev ntsuas zaum kawg yog cov teeb meem uas tau txheeb xyuas.
Tsis tas li ntawd, tsis muaj lub taub hau-rau-lub taub hau kev soj ntsuam kev sib piv ntawm unmicronized vs. micronized formulations ntawm PEA, thiab yog li cov pov thawj rau superiority ntawm ib formulation tshaj lwm yam tam sim no tsis muaj.
Txawm li cas los xij, cov ntaub ntawv kho mob uas muaj txhawb nqa kev sib cav hais tias PEA muaj cov tshuaj tua kab mob thiab txhawb kev tshawb fawb ntxiv ntawm qhov sib xyaw no, tshwj xeeb tshaj yog hais txog kev sib piv ntawm lub taub hau ntawm unmicronized vs. micronized formulations ntawm PEA thiab kev sib piv nrog cov kev kho mob tam sim no.

Cov pov thawj kho mob

Tshwj xeebKhoom noj rau Lub Hom Phiaj Kho Mob, hauvKev kho mobof Ntev Mob
Micronized palmitoylethanolamide txo covcov tsos mobof mob neuropathichauv ntshav qab zib cov neeg mob
Palmitoylethanolamide, a neutraceutical, in paj hlwb compression syndromes: kev ua tau zoo thiab kev nyab xeeb in mob sciatic thiab carpal qhov syndrome
Palmitoylethanolamide in Fibromyalgia: Cov txiaj ntsig los ntawm Yav tom ntej thiab Rov qab los Kev soj ntsuam Kev kawm
Ultra-micronized palmitoylethanolamide: ib qho ua tau zookev kho mob adjuvantrauParkinson tus kab mob

kab mob.

Ntev pelvic mob, zoo of lub neej thiab kev sib deev noj qab haus huv of poj niam kho nrog palmitoylethanolamide thiab α- lipoic acid
Randomized kho mob kev sim: tus tshuaj tua kab mob khoom of noj zaub mov kev pab ntxivnrog palmitoylethanolamide thiab polydatin hauvchim siab plob tsis so tswj syndrome.
Co-ultramicronized Palmitoylethanolamide / Luteolin in tus Kev kho mob of Cerebral Ischemia: los ntawm Nas to

Txiv neej

Palmitoylethanolamide, a Ntuj Cov tshuaj Retinoprotectant: Nws Putative Qhov tseeb rau tus Kev kho mobof Glaucomathiab Ntshav Qab Zib Retinopathy
N-palmitoylethanolamine thiab N-acetylethanolamine yog siv tau in asteatotic eczema: tshwm sim of randomized, ob-dig muag, tswj kev kawm hauv 60 cov neeg mob

Tus kws kho mob mob. 2016 Peb; 19(2:11-24).

Palmitoylethanolamide, Khoom Noj Tshwj Xeeb rau Kev Kho Mob Lub Hom Phiaj, hauv Kev Kho Mob Kho Mob: Ib Daim Ntawv Qhia Meta-analysis.

POB ZEB: Lub cev loj hlob ntawm cov pov thawj qhia tau hais tias neuroinflammation, uas yog tus cwj pwm los ntawm kev nkag mus ntawm lub cev tiv thaiv kab mob, ua kom cov hlwb mast thiab glial hlwb, thiab tsim cov inflammatory mediators nyob rau hauv lub peripheral thiab central paj hlwb, muaj lub luag hauj lwm tseem ceeb nyob rau hauv induction thiab kev kho mob. mob.Cov kev tshawb pom no txhawb cov kev xav tias kev kho mob tshiab rau cov mob ntev yuav ua raws li kev tiv thaiv kab mob thiab kev daws teeb meem uas ua rau lub cev tiv thaiv kab mob, tshwj xeeb tshaj yog cov hlwb mast thiab glia, txo qis lossis tshem tawm cov kab mob neuroinflammation.

Ntawm cov tshuaj tiv thaiv kab mob thiab kev daws teeb meem lipid mediators, palmitoylethanolamide (PEA) tau tshaj tawm rau txo qis-modulate mast cell activation thiab tswj glial cell cwj pwm.

Lub Hom Phiaj:Lub hom phiaj ntawm txoj kev tshawb no yog los ua ib qho kev sib koom ua ke ntawm kev tshuaj ntsuam xyuas los ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm micronized thiab ultra- micronizedpalmitoylethanolamide (PEA) ntawm qhov mob hnyav hauv cov neeg mob uas mob ntev thiab / lossis mob neuropathic.
KawmDESIGN:Cov ntaub ntawv txheeb xyuas suav nrog ob qhov muag tsis pom kev, tswj tau, thiab qhib-label kev sim tshuaj.
Txoj kev:Ob qhov muag tsis pom kev, tswj tau, thiab qhib-daim ntawv soj ntsuam kev sim tau raug xaiv los sab laj rau PubMed, Google Scholar, thiab Cochrane databases, thiab cov txheej txheem ntawm cov rooj sib tham neuroscience.Cov ntsiab lus mob ntev, mob neuropathic, thiab micronized thiab ultra-micronized PEA tau siv rau kev tshawb nrhiav.Cov txheej txheem xaiv suav nrog muaj cov ntaub ntawv nyoos thiab kev sib piv ntawm cov cuab yeej siv los kuaj xyuas thiab ntsuas qhov mob hnyav.Cov ntaub ntawv nyoos tau los ntawm cov kws sau ntawv tau muab sib sau ua ke hauv ib lub database thiab tshuaj xyuas los ntawm Generalized Linear Mixed Model.Cov kev hloov pauv ntawm qhov mob nyob rau lub sijhawm, ntsuas los ntawm cov cuab yeej sib piv, kuj tau soj ntsuam los ntawm linear regression post-hoc tsom xam thiab kev kwv yees Kaplan-Meier.Kaum ob txoj kev tshawb fawb tau suav nrog hauv kev sib koom ua ke ntawm kev tshuaj ntsuam xyuas, 3 ntawm qhov kev sim ob qhov muag tsis pom kev piv rau cov neeg sib piv sib piv thiab cov placebo, 2 yog kev sim qhib-label vs cov qauv kev kho mob, thiab 7 yog qhib-label sim yam tsis muaj kev sib piv.
TSEEM CEEB:Cov txiaj ntsig tau pom tias PEA txhawb nqa kev txo qis ntawm qhov mob hnyav dua li kev tswj hwm.Qhov loj ntawm kev txo qis sib npaug

1.04 cov ntsiab lus txhua 2 lub lis piam nrog 35% cov lus teb sib txawv piav qhia los ntawm cov qauv kab.Nyob rau hauv sib piv, nyob rau hauv lub tswj pab pawg neeg mob, txo kev siv sib npaug sib npaug 0.20 ntsiab lus txhua 2 lub lis piam nrog tsuas yog 1% ntawm tag nrho cov variance piav qhia los ntawm regression.Tus kwv yees Kaplan-Meier qhia qhov mob tau = 3 ntawm 81% ntawm PEA kho cov neeg mob piv rau tsuas yog 40.9% hauv kev tswj cov neeg mob los ntawm hnub 60 ntawm kev kho mob.PEA cov teebmeem yog ywj siab ntawm tus neeg mob hnub nyoog lossis poj niam txiv neej, thiab tsis cuam tshuam rau hom mob ntev.

TXOJ CAI:Qhov tseem ceeb, cov xwm txheej tsis zoo uas cuam tshuam nrog PEA tsis tau sau npe thiab / lossis tshaj tawm hauv ib qho ntawm cov kev tshawb fawb.
NYEEM NTXIV:Cov txiaj ntsig no tau lees paub tias PEA tuaj yeem sawv cev rau qhov zoo siab, kho tshiab lub tswv yim los tswj kev mob ntev thiab mob neuropathic

txuam nrog neuroinflamation.

Pain Res Kho Mob. Xyoo 2014; 2014: 849623.

Micronized palmitoylethanolamide txo cov tsos mob ntawm qhov mob neuropathic hauv cov neeg mob ntshav qab zib.

Qhov kev tshawb fawb tam sim no tau ntsuas qhov ua tau zoo ntawm

micronized palmitoylethanolamide (PEA-m) kev kho mob hauv kev txo qis cov tsos mob uas tshwm sim los ntawm cov neeg mob ntshav qab zib nrog peripheral neuropathy.

PEA-m tau muab tshuaj (300 mg ob zaug ib hnub) rau 30 tus neeg mob ntshav qab zib

kev txom nyem los ntawm mob ntshav qab zib neuropathy.

Ua ntej kev kho mob pib, tom qab 30 thiab 60 hnub cov kev ntsuas hauv qab no tau soj ntsuam: mob cov tsos mob ntawm tus mob ntshav qab zib peripheral neuropathy siv Michigan Neuropathy kuaj ntsuas;kev siv ntawm cov tsos mob yam ntxwv ntawm tus mob ntshav qab zib neuropathic mob los ntawm Tag Nrho Cov Symptom Score;thiab kev siv ntawm cov subcategories sib txawv ntawm cov mob neuropathic los ntawm Neuropathic Pain Symptoms Inventory.Hematological thiab ntshav chemistry kuaj los ntsuas kev tswj cov metabolism thiab kev nyab xeeb kuj tau ua.
Kev txheeb xyuas txheeb cais (ANOVA) tau qhia txog qhov txo qis ntawm qhov mob hnyav (P <0.0001) thiab cov tsos mob ntsig txog (P <0.0001) soj ntsuam los ntawm Michigan Neuropathy Screening instrument, Tag Nrho Cov Symptom Score, thiab Neuropathic Pain Symptoms Inventory.
Kev soj ntsuam hematological thiab tso zis tsis tau qhia txog kev hloov pauv cuam tshuam nrog kev kho PEA-m, thiab tsis muaj qhov tshwm sim tsis zoo tshwm sim.
Cov txiaj ntsig no qhia tau tias PEA-m tuaj yeem suav tias yog qhov kev cog lus thiab ua tau zoo rau kev kho mob tshiab rau cov tsos mob uas tau ntsib los ntawm cov neeg mob ntshav qab zib uas raug kev txom nyem los ntawm peripheral neuropathy.

J Pain Res. Peb Hlis 23, 2015; 8:729-34.

Palmitoylethanolamide, ib tug neutraceutical, nyob rau hauv paj hlwb compression syndromes: kev ua tau zoo thiab kev nyab xeeb nyob rau hauv sciatic mob thiab carpal tunnel syndrome.

Ntawm no peb piav qhia txog cov txiaj ntsig ntawm txhua qhov kev sim tshuaj ntsuam xyuas PEA qhov ua tau zoo thiab kev nyab xeeb hauv cov hlab ntsha compression syndromes: mob sciatic thiab mob vim carpal tunnel syndrome, thiab tshuaj xyuas cov pov thawj preclinical hauv cov paj hlwb impingement qauv.
- Nyob rau hauv tag nrho, yim qhov kev sim tshuaj tau luam tawm nyob rau hauv xws li mob khaub thuas, thiab 1,366 tus neeg mob tau suav nrog hauv cov kev sim no.
- Hauv ib qho piv txwv, ob qhov muag tsis pom kev, cov placebo tswj kev sim hauv 636 tus neeg mob sciatic mob, tus lej xav tau los kho kom ncav cuag 50% qhov mob txo qis piv rau cov hauv paus yog 1.5 tom qab 3 lub lis piam kho.
- PEA tau ua pov thawj tias muaj txiaj ntsig zoo thiab muaj kev nyab xeeb hauv cov hlab ntsha compression syndromes, tsis muaj kev cuam tshuam tshuaj los yog teeb meem tshwm sim tau piav qhia.
- PEA yuav tsum raug suav hais tias yog qhov kev xaiv kho tshiab thiab nyab xeeb rau cov paj hlwb compression syndromes.
  - Txij li feem ntau cov tshuaj co-analgesic pregabaline tau raug pov thawj

kom tsis muaj txiaj ntsig hauv qhov mob sciatic hauv kev sim ob qhov muag tsis pom kev ntxiv.

Cov kws kho mob tsis yog ib txwm paub txog PEA uas yog ib qho tseem ceeb thiab muaj kev nyab xeeb rau kev siv tshuaj opioids thiab co-analgesics hauv kev kho mob neuropathic.

NNT ntawm PEA kom ncav cuag 50%

txo qhov mob

PEA, palmitoylethanolamide;VAS, visual analog scale;NNT, tus lej xav tau los kho

Mob Ther. Kaum Ib Hlis 2015; 4(2): 169-78.

Palmitoylethanolamide hauv Fibromyalgia: Cov txiaj ntsig los ntawm Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab Kev Tshawb Fawb Txog Kev Tshawb Fawb.

(Duloxetine + Pregabalin)

Txo tus naj npawb ntawm cov ntsiab lus zoo sib tw

Txo qhov mob hnyav los ntawm kev ntsuas VAS.

CNS Neurol Disord Drug Targets. 21 Peb 2017.

Ultra-micronized palmitoylethanolamide: ib qho kev kho mob zoo rau Parkinson's disease.

POB ZEB:Parkinson's disease (PD) yog qhov kev mob siab rau kev tsim cov tswv yim uas ua rau qeeb lossis nres kev kis kab mob thiab kev tsis taus.Cov ntaub ntawv pov thawj tseem ceeb qhia txog lub luag haujlwm tseem ceeb rau neuroinflamation nyob rau hauv lub hauv paus dopaminergic cell tuag.Ultramicronized palmitoylethanolamide (um-PEA) paub zoo txog nws lub peev xwm los txhawb kev daws teeb meem ntawm neuroinflammation thiab tawm dag zog neuroprotection.Txoj kev tshawb no tau tsim los ntsuas qhov ua tau zoo ntawm um-PEA raws li kev kho mob ntxiv rau cov neeg mob uas muaj PD siab heev.

Txoj kev:Peb caug PD cov neeg mob tau txais levodopa tau suav nrog hauv txoj kev tshawb no.Daim ntawv kho dua- Movement Disorder Society/Unified Parkinson's Disease Rating Scale (MDS-UPDRS) cov lus nug tau siv los tshuaj xyuas cov tsos mob ntawm lub cev muaj zog thiab tsis yog lub cev muaj zog.Kev soj ntsuam kev soj ntsuam tau ua ua ntej thiab tom qab ntxiv um-PEA (600 mg).MDS-UPDRS daim ntawv nug tag nrho cov qhab nia rau seem I, II, III, thiab IV raug tshuaj xyuas siv Generalized Linear Mixed Model, ua raws li Wilcoxon kos npe-qib xeem los ntsuas qhov sib txawv ntawm txhua yam ntsiab lus qhab nia nruab nrab ntawm lub hauv paus thiab qhov kawg ntawm um-PEA kev kho mob.

TSEEM CEEB:Ntxiv ntawm um-PEA rau PD cov neeg mob tau txais kev kho mob levodopa tau txo qis qhov tseem ceeb thiab nce zuj zus ntawm tag nrho cov qhab nia MDS-UPDRS (chaw I, II, III thiab IV).Rau txhua yam khoom, qhov qhab nia nruab nrab qhov sib txawv ntawm qhov pib thiab qhov kawg ntawm um-PEA kev kho mob pom tau tias txo qis hauv feem ntau cov tsos mob uas tsis yog lub cev muaj zog thiab lub cev muaj zog.Tus naj npawb ntawm cov neeg mob uas muaj cov tsos mob ntawm basal tau txo qis tom qab ib xyoos ntawm kev kho um-PEA.Tsis muaj leej twg ntawm cov neeg koom tau tshaj tawm cov kev mob tshwm sim los ntawm qhov sib ntxiv ntawm um-PEA.

NYEEM NTXIV:um-PEA ua rau qeeb zuj zus ntawm cov kab mob thiab kev xiam oob qhab hauv cov neeg mob PD, qhia tias um-PEA yuav yog ib qho kev kho mob zoo rau PD.

Minerva Ginecol. Peb Hlis 2015; 67(5:413-9.

Mob pelvic mob ntev, lub neej zoo thiab kev sib deev kev noj qab haus huv ntawm cov poj niam kho nrog palmitoylethanolamide thiab α-lipoic acid.

Lub hom phiaj ntawm daim ntawv no yog los ntsuas qhov cuam tshuam ntawm lub koom haum

nruab nrab ntawm palmitoylethanolamide (PEA) thiab α-lipoic acid (LA) ntawm lub neej zoo (QoL) thiab kev ua haujlwm ntawm kev sib deev hauv cov poj niam cuam tshuam los ntawm kev mob endometriosis-uas cuam tshuam pelvic mob.

Tsib caug-rau tus poj niam koom nrog pawg kawm thiab tau muab PEA 300 mg thiab LA 300mg ob zaug ib hnub.
Txhawm rau txheeb xyuas qhov mob endometriosis-uas cuam tshuam nrog lub plab, qhov pom kev sib piv (VAS) tau siv.Daim Ntawv Qhia luv luv-36 (SF-36), Cov Poj Niam Kev Ua Haujlwm Kev Ua Haujlwm Zoo (FSFI) thiab Cov Poj Niam Kev Nyuaj Siab Scale (FSDS) tau siv los ntsuas QoL, kev ua haujlwm ntawm kev sib deev thiab kev sib deev kev nyuaj siab, raws li.Txoj kev tshawb no suav nrog peb qhov kev soj ntsuam ntawm 3, 6 thiab 9 lub hlis.
Tsis muaj kev hloov pauv hauv qhov mob, QoL thiab kev ua haujlwm ntawm kev sib deev ntawm lub hlis thib 3 (P = NS).Thaum lub hli 6 thiab 9, cov tsos mob mob (P<0.001) thiab txhua pawg ntawm QoL (P<0.001) tau txhim kho.FSFI thiab FSDS cov qhab nia tsis tau hloov pauv ntawm 3rd lub hlis tom qab (P = ns).Ntawm qhov tsis sib xws, ntawm 3rd thiab 9th lub hlis tom qab lawv tau txhim kho raws li cov hauv paus ntsiab lus (P<0.001).
Kev txo qis ntawm qhov mob tshwm sim los ntawm cov poj niam nyob rau lub sijhawm kho mob tuaj yeem pab txhim kho QoL thiab kev sib deev lub neej ntawm cov poj niam ntawm PEA thiab LA.

Arch Ital Urol Androl. 2017 Mar 31;89(1:17-21.

Kev ua tau zoo ntawm kev koom tes ntawm palmitoylethanolamide thiab alpha-lipoic acid hauv cov neeg mob uas muaj mob prostatitis / chronic pelvic pain syndrome: Kev sim tshuaj ntsuam xyuas randomized.

POB ZEB:Chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS) yog ib qho mob nyuaj, uas yog tus cwj pwm los ntawm qhov tsis paub meej etiology thiab los ntawm cov lus teb rau kev kho.Lub ntsiab lus ntawm CP / CPPS suav nrog qhov mob genitourinary nrog lossis tsis muaj cov tsos mob tshwm sim thaum tsis muaj cov kab mob uropathogenic, raws li kuaj pom los ntawm cov txheej txheem microbiological, lossis lwm yam ua rau muaj xws li malignancy.Kev ua tau zoo ntawm ntau yam kev kho mob, tau raug soj ntsuam hauv kev tshawb fawb soj ntsuam, tab sis cov pov thawj tsis muaj lossis tsis sib haum.Peb piv Serenoa Repens hauv monotherapy piv rau Palmitoylethanolamide (PEA) ua ke nrog Alpha-lipoic acid (ALA) thiab ntsuas qhov ua tau zoo ntawm cov kev kho mob no hauv cov neeg mob CP / CPPS.
Txoj kev:Peb tau ua qhov kev sim randomized, ib leeg dig muag.44 tus neeg mob kuaj pom muaj CP/CPPS (lub hnub nyoog nruab nrab

41.32 ± 1.686 xyoo) raug muab tso rau kev kho mob nrog Palmitoylethanolamide 300 mg ntxiv rau Alpha-lipoic acid 300 mg (Peanase®), lossis Serenoa Repens ntawm 320 mg.Peb daim ntawv nug (NIH-CPSI, IPSS thiab IIEF5) tau muab coj los siv rau ntawm qhov pib thiab tom qab 12 lub lis piam ntawm kev kho mob hauv txhua pab pawg.

TSEEM CEEB:12 lub lis piam kev kho mob nrog Peanase tau txhim kho qhov qhab nia IPSS piv rau tib lub sijhawm ntawm kev kho mob nrog Serenoa Repens, thiab txo qis NIH-CPSI qhab nia.Cov txiaj ntsig zoo sib xws tau pom hauv qhov sib txawv NIH-CPSI subscores tawg.Txawm li cas los xij, tib txoj kev kho mob tsis ua rau muaj kev txhim kho tseem ceeb ntawm qhov qhab nia IIEF5.Ob txoj kev kho mob tsis tau tsim cov teebmeem uas tsis xav tau.
Cov ntsiab lus: Cov txiaj ntsig tam sim no sau txog kev ua tau zoo ntawm kev koom tes ntawm Palmitoylethanolamide (PEA) thiab Alpha-lipoic acid (ALA) siv rau 12 lub lis piam rau kev kho cov neeg mob nrog CP / CPPS, piv nrog Serenoa Repens monotherapy.

Aliment Pharmacol Ther. 2017 Peb 6.

Randomized soj ntsuam sim: lub analgesic zog ntawmnoj zaub mov kev pab ntxiv

nrog palmitoylethanolamide thiab polydatin nyob rau hauv chim siab plob tsis so tswj syndrome.

POB ZEB:Kev ua kom lub plab zom mov yog koom nrog hauv kev chim siab plob tsis so tswj (IBS) pathophysiology.Thaum feem ntau txoj hauv kev noj zaub mov hauv IBS koom nrog kev zam zaub mov, muaj tsawg qhov qhia txog kev noj zaub mov ntxiv.Palmithoylethanolamide, structurally ntsig txog endocannabinoid anandamide, thiab polydatin yog cov khoom noj khoom haus uas ua haujlwm sib koom ua ke los txo cov kev ua haujlwm ntawm tes.
AIM:Txhawm rau soj ntsuam cov txiaj ntsig ntawm mast cell suav thiab kev ua tau zoo ntawm palmithoylethanolamide / polydatin hauv cov neeg mob IBS.
Txoj kev:Peb tau ua tus tsav, 12-lub lim tiam, randomised, ob-dig muag, placebo-tswj, multicentre txoj kev tshawb fawb soj ntsuam cov nyhuv ntawm palmithoylethanolamide / polydatin 200 mg / 20 mg lossis placebo bd ntawm qib qis tiv thaiv kab mob, endocannabinoid system thiab cov tsos mob hauv IBS cov neeg mob. .Cov qauv kuaj biopsy, tau txais ntawm kev kuaj xyuas thiab thaum kawg ntawm txoj kev tshawb no, tau soj ntsuam los ntawm immunohistochemistry, enzyme-txuas immunoassay, kua chromatography thiab Western blot.
TSEEM CEEB:Tag nrho ntawm 54 tus neeg mob nrog IBS thiab 12 kev tswj hwm kev noj qab haus huv tau tso npe los ntawm tsib lub chaw nyob sab Europe.Piv nrog rau kev tswj hwm, IBS cov neeg mob tau pom ntau dua mucosal mast cell suav (3.2 ± 1.3 vs. 5.3 ± 2.7%,

P = 0.013), txo fatty acid amide oleoylethanolamide (12.7 ± 9.8 vs. 45.8 ± 55.6 pmol/mg, P = 0.002) thiab nce kev qhia ntawm cannabinoid receptor 2 (0.7 ± 0.1 vs. 1.0 ± 0.8, P = 0.01).Cov kev kho mob tsis tau hloov kho IBS lom neeg profile, suav nrog mast cell suav.Piv nrog rau cov placebo, palmithoylethanolamide/polydatin tau txhim kho qhov mob plab (P <0.05).

Cov ntsiab lus:Cov txiaj ntsig ntawm kev noj zaub mov ntxiv palmithoylethanolamide / polydatin ntawm qhov mob plab hauv cov neeg mob IBS qhia tias qhov no yog txoj hauv kev zoo rau kev tswj qhov mob hauv qhov xwm txheej no.Cov kev tshawb fawb ntxiv tam sim no yuav tsum tau piav qhia txog cov txheej txheem ntawm kev ua ntawm palmithoylethanolamide / polydatin hauv IBS.ClinicalTrials.gov tus lej,NCT01370720.

Transl Stroke Res. 2016 Feb; 7(1:54-69.

Co-ultramicronized Palmitoylethanolamide / Luteolin hauv Kev Kho Mob Cerebral Ischemia: Los ntawm Rodent rau Txiv Neej.

Cov neeg mob tau muab Glialia® rau lub sijhawm 60 hnub.

Barthel Index qhov tseem ceeb yog 26.6 ± 1.69, 48.3 ± 1.91, thiab 60.5 ± 1.95 ntawm T0 (242

T30 (229 tus neeg mob), thiab T60 (218

cov neeg mob), feem.

Muaj qhov sib txawv tseem ceeb hauv kev txhim kho ntawm T0 thiab T30 (***p<0.0001) thiab nruab nrab ntawm T0 thiab T60 (###p<0.0001).Ntxiv mus, muaj qhov sib txawv tseem ceeb ntawm T30 thiab T60 (p<0.0001).

Cov poj niam cov neeg mob pom cov qhab nia qis dua li cov txiv neej, thiab kev xiam oob khab hnyav dua hauv cov neeg mob

Drug Des Devel Ther. 2016 Sep 27; 10:3133-3141.

Resolvins thiab aliamides: lipid autacoids hauv ophthalmology - lawv cog lus li cas?

Resolvins (Rvs) yog chav kawm tshiab ntawmlipid-derived endogenous molecules(autacoids) nrog lub zog immunomodulating zog, uas tswj cov theem kev daws teeb meem ntawm lub cev tiv thaiv kab mob.
- Cov kev hloov pauv no tau tsim hauv zos, cuam tshuam rau kev ua haujlwm ntawm cov hlwb thiab / lossis cov ntaub so ntswg, uas yog tsim los ntawm kev thov thiab tom qab metabolized hauv tib lub hlwb thiab / lossis cov ntaub so ntswg.
- Autacoid pharmacology, tsim nyob rau hauv lub xyoo 1970s, cov tshuaj autacoid yog lub cev-tus kheej cov ntsiab lus lawv tus kheej los yog cov precursors los yog lwm yam derivatives ntawm no, nyiam dua raws li yooj yim chemistry, xws li 5- hydroxytryptophan, precursor rau serotonin.
- Lub luag haujlwm tseem ceeb ntawm autacoids teej tug mus rau cov chav kawm no yog inhibit hyperactivated immune cascades thiab yog li ua zoo li "stop" teeb liab nyob rau hauv cov txheej txheem o txwv tsis pub ua pathological.
  - Xyoo 1993, Nobel laureate Rita Levi-Montalcini (1909-2012) tau tsim lub sij hawm "aliamides" rau cov tebchaw no, thaum ua haujlwm ntawm inhibiting thiab modulating luag hauj lwm ntawm palmitoylethanolamide (PEA) nyob rau hauv overactive mast hlwb.
  - Lub tswv yim ntawm aliamides tau muab los ntawm lub ntsiab lusALIA: autacoid hauv zos mob antagonist.
  - Lub sij hawm pom nws txoj hauv kevN-acetylethanolamides autacoids, xws li PEA, txawm hais tias "aliamide" tau txhais los ntawm Levi-Montalcini raws li lub ntsiab lus ntim rau tag nrho cov lipid-inhibiting thiab -modulating mediators.Qhov ntawd tseem yuav suav nrog Rvs, tiv thaiv, thiab maresins.
  - Rvs yog metabolites ntawm polyunsaturated ω-3 fatty acids: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), thiab docosapentaenoic acid (DPA).
    - Cov metabolites ntawm EPA yog hu ua E Rvs (RvEs), cov DHA yog hu ua D Rvs (RvDs), thiab cov DPA yog hu ua Rvs D.

(RvDsn-3DPA) thiab Rvs T (RvTs).

Protectins thiab maresins yog muab los ntawm ω-3 fatty acid DHA.

J Ophthalmol. Xyoo 2015; 2015: 430596.

Palmitoylethanolamide, Ib Lub Ntuj Retinoprotectant: Nws Cov Ntsiab Lus Tseem Ceeb rau Kev Kho Mob Glaucoma thiab Diabetic Retinopathy.

Retinopathy yog ib qho kev hem thawj rau lub qhov muag, thiab glaucoma thiab ntshav qab zib yog lub ntsiab ua rau kev puas tsuaj ntawm cov hlwb retinal.Cov kev pom tsis ntev los no tau taw qhia txog txoj hauv kev uas muaj kab mob rau ob qho tib si, raws li kev mob ntev.

PEA tau raug tshuaj xyuas rau glaucoma, ntshav qab zib retinopathy, thiab uveitis, pathological xeev raws li mob ntev, ua pa tsis zoo, thiab ntau yam mob mob hauv ntau qhov kev sim tshuaj txij li xyoo 70s ntawm xyoo pua 20th.

PEA tau raug sim nyob rau hauv tsawg kawg 9 ob qhov muag tsis pom cov placebo kev tshawb fawb, ntawm ob qhov kev tshawb fawb tau nyob rau hauv glaucoma, thiab pom tias muaj kev nyab xeeb thiab siv tau txog li 1.8 g / hnub, nrog rau kev ua tau zoo heev.PEA yog li ntawd tuav cov lus cog tseg hauv kev kho mob ntawm ntau tus kab mob retinopathies.

PEA muaj nyob rau hauv cov khoom noj ntxiv (PeaPure) thiab ua zaub mov noj rau kev kho mob hauv tebchaws Ltalis (Normast, PeaVera, thiab Visimast).

Cov khoom no tau ceeb toom nyob rau hauv ltalis rau cov khoom noj khoom haus kev txhawb nqa hauv glaucoma thiab neuroinflamation.Peb tham txog PEA ua cov tshuaj tiv thaiv kab mob thiab retinoprotectant compound hauv kev kho mob retinopathies, tshwj xeeb tshaj yog muaj feem xyuam rau glaucoma thiab ntshav qab zib.

Txawv molecular hom phiaj ntawm PEA.PPAR: peroxisome proliferator activated receptor;GPR-55: 119- menyuam ntsuag G-protein coupled receptors;CCL: chemokine ligand;COX: cyclooxygenase;iNOS: inducible nitric oxide synthase;TRPV: ib ntus receptor muaj peev xwm cation channel subfamily V;IL: interleukin;Kv1.5,4.3: potassium voltage gated channels;Tus xov tooj hu-4 R: hu xov tooj zoo li receptor.

Clin Interv Aging. 2014 Lub Xya Hli 17; 9: 1163-9.

N-palmitoylethanolamine thiab N-acetylethanolamine muaj txiaj ntsig zoo hauv asteatotic eczema: cov txiaj ntsig ntawm kev sib tw, ob-dig muag, tswj kev kawm hauv 60 tus neeg mob.

POB ZEB:Asteatotic eczema (AE) yog cov tsos mob khaus, qhuav, ntxhib, thiab scaling ntawm daim tawv nqaij.Cov kev kho mob rau AE feem ntau yog emollients, feem ntau muaj urea, lactic acid, los yog lactate ntsev.N-palmitoylethanolamine (PEA) thiab N- acetylethanolamine (AEA) yog ob qho tib si endogenous lipids siv los ua cov cuab yeej kho tshiab hauv kev kho mob ntawm ntau yam kab mob ntawm daim tawv nqaij.Lub hom phiaj ntawm txoj kev tshawb no yog los sib piv PEA/AEA emollient nrog ib txwm emollient hauv kev kho mob ntawm AE.
Txoj kev:Ib qho monocentric, randomized, ob qhov muag tsis pom kev, kev sib piv tau ua nyob rau hauv 60 AE cov neeg mob los ntsuas thiab sib piv qhov ua tau zoo ntawm ob lub emollients.Cov theem ntawm daim tawv nqaij dryness ntawm cov kev kawm ranges ntawm me me mus rau nruab nrab.Cov neeg ua haujlwm ntawm daim tawv nqaij barrier muaj nuj nqi thiab qhov kev nkag siab tam sim no tau sim rau 28 hnub los ntawm kev soj ntsuam cov qhab nia thiab bioengineering technology.
TSEEM CEEB:Cov txiaj ntsig tau pom tias, txawm hais tias qee yam tau txhim kho hauv ob pawg, cov pab pawg siv cov emollient uas muaj PEA / AEA tau nthuav tawm cov tawv nqaij zoo dua ntawm kev hloov pauv hauv lub peev xwm.Txawm li cas los xij, qhov kev pom zoo tshaj plaws yog lub peev xwm ntawm PEA / AEA emollient kom nce 5 Hz tam sim no kev nkag siab qhov pib mus rau qib qub tom qab 7 hnub, nrog qhov sib txawv ntawm qhov tseem ceeb ntawm qhov pib thiab tom qab 14 hnub.Qhov kev nkag siab tam sim no ntawm 5 Hz tau zoo thiab cuam tshuam nrog cov tawv nqaij hydration thiab tsis zoo cuam tshuam nrog cov dej tsis zoo hauv PEA / AEA emollient pawg.
CONLUTION: Piv nrog rau cov tshuaj emollients ib txwm siv, kev siv tshuaj pleev ib ce PEA / AEA emollient tuaj yeem txhim kho ob qho tib si ntawm daim tawv nqaij ua haujlwm thiab nquag ua haujlwm ib txhij.

Kev hloov ntawm daim tawv nqaij hydration tshaj 28 hnub

Piv nrog rau cov tshuaj emollient ib txwm muaj, PEA / AEA emollient tuaj yeem tswj hwm ob qho tib si "passive" thiab "active" daim tawv nqaij ua haujlwm, suav nrog kev tsim kho ntawm daim tawv nqaij thiab kho cov lipid lamellae, tawv nqaij, thiab kev tiv thaiv kab mob.

PEA ua haujlwm li cas

Lub mechanism (s) ntawm kev ua ntawmPEA koom nrognws cov teebmeem ntawm nucleartus neeg txais kev pabPIB α(Gabrielsson li al., 2016).
Nws kuj suav nrog mast hlwb, cannabinoidtus neeg txais kev pabHom 2 (CB2)-nyiamcannabinoidreceptors,ATP-rhiab heev potassium-channels, ncua sijhawmtus neeg txais kev pabmuaj peev xwm (TRP) channel, thiab nuclearyamkab B (NFkB).
Nws ua taucuam tshuamendocannabinoid signaling los ntawm kev ua raws li kev sib twsubstrate rauendocannabinoid homologue anandamide (N- arachidonoylethanolamine).
Lub plab-hlwb axis: Lub luag haujlwm ntawm lipids hauv cov kev cai ntawm o, mob thiab CNS kab mob.

Curr Med Chem. 2017 Peb

16.

Lub plab-hlwb axis: Lub luag haujlwm ntawm lipids hauv kev tswj kev mob, mob thiab CNS kab mob.

Tib neeg lub plab yog qhov sib xyaw ua ke anaerobic ib puag ncig nrog qhov loj, muaj ntau haiv neeg thiab muaj zog enteric microbiota, sawv cev los ntawm ntau dua 100 trillion kab mob, suav nrog tsawg kawg 1000 hom sib txawv.
Kev tshawb pom tias qhov sib txawv ntawm cov kab mob microbial tuaj yeem cuam tshuam tus cwj pwm thiab kev paub, thiab dhau los ntawm lub paj hlwb tuaj yeem cuam tshuam ncaj qha rau enteric microbiota muaj pes tsawg leeg, tau ua rau muaj txiaj ntsig zoo los tsim lub tswv yim zoo ntawm lub plab-hlwb axis.

Qhov kev xav no tau txais kev txhawb nqa los ntawm ntau cov pov thawj uas qhia txog kev sib koom ua ke, uas koom nrog cov paj hlwb tsis meej, lub cev tsis muaj zog, hypothalamic-pituitary-adrenal (HPA) axis modulation thiab cov kab mob-derived.

metabolites.

Ntau cov kev tshawb fawb tau tsom mus rau delineating lub luag hauj lwm rau lub axis no nyob rau hauv kev noj qab haus huv thiab kab mob, xws li los ntawm cov kev ntxhov siab-txoj kev mob xws li kev nyuaj siab, ntxhov siab vim thiab chim siab plob tsis so tswj syndrome (IBS) mus rau neurodevelopmental disorders, xws li autism, thiab rau neurodegenerative kab mob, xws li Parkinson. Kab mob, Alzheimer Disease thiab lwm yam.

Raws li keeb kwm yav dhau los no, thiab txiav txim siab qhov cuam tshuam ntawm kev hloov pauv ntawm symbiotic xeev ntawm tus tswv tsev thiab microbiota, qhov kev tshuaj xyuas no tsom mus rau lub luag haujlwm thiab kev koom tes ntawm bioactive lipids, xws li N-acylethanolamine (NAE) tsev neeg uas nws cov tswv cuab tseem ceeb yog N-arachidonoylethanolamine. (AEA), palmitoylethanolamide (PEA) thiab oleoilethanolamide (OEA), thiab luv saw fatty acids (SCFAs), xws li butyrate, teej tug mus rau ib pawg loj ntawm bioactive lipids muaj peev xwm hloov kho peripheral thiab central pathologic txheej txheem.

Nws yog zoo tsim lawv lub luag hauj lwm zoo nyob rau hauv o, mob thiab mob ntev, rog rog thiab central paj hlwb kab mob.Nws tau pom tias muaj kev sib raug zoo ntawm cov lipids thiab plab microbiota los ntawm ntau yam kev sib txawv.Tseeb tiag, kev tswj hwm cov kab mob tshwj xeeb tuaj yeem txo qhov mob plab los ntawm kev koom tes ntawm cannabinoid receptor 1 hauv nas;Ntawm qhov tod tes, PEA txo cov cim o hauv cov qauv murine ntawm cov kab mob plob tsis so tswj (IBD), thiab butyrate, tsim los ntawm plab microbiota, muaj txiaj ntsig zoo hauv kev txo qhov mob thiab mob hauv plab hnyuv siab raum thiab IBD tsiaj qauv.

Hauv kev tshuaj xyuas no, peb piav qhia txog kev sib raug zoo ntawm kev mob, mob, microbiota thiab cov lipids sib txawv, tsom mus rau kev koom tes ntawm NAEs thiab SCFAs hauv plab-hlwb axis thiab lawv lub luag haujlwm hauv cov kab mob hauv nruab nrog cev.

Cov teebmeem ntawm palmitoylethanolamide (PEA) ntawm Akt/mTOR/p70S6K axis activation thiab HIF-1α qhia hauv DSS-induced colitis thiab nyob rau hauv ulcerative colitis

PLoS Ib.2016;11(5): e0156198.

Palmitoylethanolamide (PEA) inhibits colitis-associated angiogenesis hauv cov nas.(A) DSS-induced colitis ua rau muaj kev nce ntxiv ntawm Hb-cov ntsiab lus hauv colonic mucosa, PEA muaj peev xwm txo tau, nyob rau hauv ib koob tshuaj, Hb-cov ntsiab lus nyob rau hauv colitis nas;Qhov no tshwm sim nyob rau hauv lub xub ntiag ntawm PPARγ antagonist (GW9662) thaum nws yog nullified los ntawm PPARα antagonist (MK866).(B) Immunohistochemical cov duab uas qhia txog CD31 ntawm cov nas uas tsis tau kho cov kab mob colonic mucosa (panel 1), DSS-kho nas colonic mucosa (panel 2), DSS-kho nas colonic mucosa nyob rau hauv muaj PEA (10 mg/Kg) ib leeg (vaj huam sib luag 3), PEA (10 mg/Kg) plus MK866 10 mg/Kg (panel 4), thiab PEA (10 mg/Kg) plus GW9662 1 mg/Kg (panel 5).Magnification 20X;scale bar: 100μm.Daim duab qhia txog qhov txheeb ze ntawm CD31 qhia (%) ntawm cov nas colonic mucosa hauv tib pawg sim, qhia txog qhov txo qis ntawm CD31 qhia hauv cov nas colitic tom qab PEA tswj hwm, tshwj tsis yog cov pab pawg kuj tau kho nrog cov antagonist ntawm PPARα.

(C) VEGF tso tawm ua rau muaj kev nce hauv DSS-kho nas thiab nws tau txo qis los ntawm PEA kev kho mob nyob rau hauv PPARα raws li.(D) Western blot tsom xam thiab

txheeb ze densitometric tsom xam (arbitrary units normalized nyob rau hauv cov kev qhia ntawm housekeeping protein β-actin) ntawm VEGF-receptor (VEGF-R) qhia, qhia zoo xws li cov txiaj ntsig rau VEGF tso tawm.Cov txiaj ntsig tau qhia raws li qhov txhais tau tias ± SD.*p<0.05, **p<0.01 thiab ***p<0.001 piv rau DSS-kho nas

PLoS Ib.2016;11(5): e0156198.

Sci Rep. Peb Hlis 23, 2017, 7(1): 375.

Palmitoylethanolamide induces microglia kev hloov pauv cuam tshuam nrog nce kev tsiv teb tsaws thiab kev ua phagocytic: kev koom tes ntawm CB2 receptor.

Cov tshuaj endogenous fatty acid amide palmitoylethanolamide (PEA) tau pom tias siv cov tshuaj tiv thaiv kab mob feem ntau los ntawm inhibition ntawm kev tso tawm cov pro-inflammatory molecules los ntawm mast hlwb, monocytes thiab macrophages.Indirect activation ntawm endocannabinoid (eCB) system yog ntawm ob peb lub tswv yim ntawm kev nqis tes ua uas tau npaj siab los qhia txog qhov sib txawv ntawm PEA hauv vivo.
Hauv txoj kev tshawb no, peb siv cov kab mob nas microglia thiab tib neeg macrophages los ntsuas seb PEA puas cuam tshuam rau eCB signaling.
PEA tau pom tias nce CB2 mRNA thiab cov protein qhia los ntawm peroxisome proliferator-activated receptor-α (PPAR-α) ua kom.
- Qhov kev tswj hwm noob caj noob ces tshiab no tau pom los ntawm: (i)

pharmacological PPAR-α manipulation, (ii) PPAR-α mRNA silencing,

(iii) chromatin immunoprecipitation.

Ntxiv mus, raug rau PEA induced morphological hloov pauv nrog ib tug reactive microglial phenotype, nrog rau nce phagocytosis thiab migratory kev ua si.
Peb qhov kev tshawb pom qhia txog kev tswj tsis ncaj ntawm microglial CB2R qhia raws li lub tswv yim tshiab ua tau raws li qhov cuam tshuam ntawm PEA.PEA tuaj yeem tshawb nrhiav los ua ib qho cuab yeej siv tau los tiv thaiv / kho cov tsos mob cuam tshuam nrog neuroinflamation hauv CNS cov teeb meem.

Qauv ntawm 2-AG metabolism thiab nws muaj peev xwm pab tau rau kev mob tom qab phais.Enzymes uas kho 2-AG metabolism.2-AG metabolism tshwm sim feem ntau los ntawm hydrolysis los ntawm monoacylglycerol lipase (MAGL), yielding arachidonic acid, uas yog tom qab hloov mus rau hauv eicosanoids los ntawm COX thiab LOX enzymes.Tsis tas li ntawd, 2-AG tuaj yeem metabolized rau hauv prostaglandin glycerol esters (PG-Gs) los ntawm COX-2 thiab hydroperoxyeicosatetraenoic acid glycerol esters (HETE-Gs) los ntawm LOX enzymes.

Mob. 2015 Feb; 156(2:341-7.

Pharmacol Res Perspect. 27 Lub Ob Hlis 2017; 5(2):e00300.

Cov tshuaj tiv thaiv kab mob palmitoylethanolamide inhibits prostaglandin thiab hydroxyeicosatetraenoic acid ntau lawm los ntawm macrophage cell kab.

Qhov cuam tshuam ntawm PEA raws li qib ntawm (A) PGD2;(B) PGE2;(C) 11-HETE;(D) 15-HETE;(E) 9-HODE thiab (F) 13-HODE hauv

LPS + IFNγ- kho RAW264.7 hlwb.

Cells (2.5 × 105 rau ib qhov dej) tau ntxiv rau 6 lub qhov dej nrog LPS (0.1)μg / ml zoo) thiab INFγ (100 U / ml) thiab kab lis kev cai ntawm 37 ° C rau 24 teev.PEB (3μmol / L, P3;lub 10μmol / L, P10) lossis lub tsheb tau ntxiv thaum pib ntawm lub sijhawm no ("24 h") lossis rau 30 feeb tom qab LPS + INFγ theem incubation ("30 feeb").

CovP qhov tseem ceeb yog los ntawm cov qauv linear rau cov teebmeem tseem ceeb ib leeg (sab saum toj peb kab,ti = lub sijhawm tivthaiv, nrog 30 min raws li tus nqi siv) lossis rau tus qauv suav nrog kev sib cuam tshuam (hauv qab ob kab), suav nrogt-distributions txiav txim los ntawm bootstrap nrog hloov sampling (10,000 iterations) ntawm cov ntaub ntawv nyob rau hauv lub null hypothesis.Qhov ua tau thiab qhov tshwm sim tau tshwm sim, chij nyob rau hauv Boxplot (Tukey) cov phiaj xwm, tau pom tias yog daim duab peb sab thiab cov squares liab, feem.Qhov ua tau outliers tau suav nrog hauv cov kev txheeb xyuas txheeb cais, qhov uas qhov tshwm sim qhov tshwm sim tau raug cais tawm.Bars sawv cev rau qhov nruab nrab qhov tseem ceeb tom qab kev cais tawm ntawm qhov yuav tshwm sim outlier (n = 11–12).Rau 11-HETE, lubP Qhov tseem ceeb rau tag nrho cov ntaub ntawv teev (piv txwv li suav nrog qhov yuav tshwm sim tau) yog:ti, 0,87; ib.P3, 0,86;P10, 0.0020;ti × P3, 0.83;ti x 10, 93.

Kev siv PEA

PEA tam sim no muaj nyob thoob ntiaj teb hauv daim ntawv ntawm cov khoom noj khoom haus, cov khoom noj kho mob, thiab / lossis cov khoom noj khoom haus hauv cov qauv sib txawv, nrog thiab tsis muaj excipients (Hesselink thiab Kopsky, 2015).
PEA yog tam sim no ua lag luam rau cov kws kho tsiaj (cov mob ntawm daim tawv nqaij, Redonyl ™, tsim los ntawm Innovet) thiab raws li ib tug nutraceutical nyob rau hauv tib neeg (Normast ™ thiab Pelvilen ™, tsim los ntawm Epitech; PeaPure™, tsim los ntawm JP Russel Science Ltd.) nyob rau hauv ib co European lub teb chaws. (xws li Ltalis, Spain thiab Netherlands) (Gabrielsson li al., 2016).
Nws kuj yog ib qho khoom siv ntawm cov tshuaj nplaum (Physiogel AI ™, tsim los ntawm Stiefel) ua lag luam rau cov tawv nqaij qhuav (Gabrielsson li al., 2016).
Ultramicronized PEA tau sau npe ua zaub mov rau lub hom phiaj tshwj xeeb los ntawm Italian Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab tsis tau sau npe siv rau kev mob neuropathic (Andersen li al., 2015).
Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) yav dhau los tsis tau tshuaj xyuas kev nyab xeeb ntawm PEA.Tsis muaj kev cai lij choj hauv Teb Chaws Asmeskas tso cai siv PEA ua cov khoom noj ntxiv lossis GRAS.

FDA ntawm Medical Food

• Hauv Teb Chaws Asmeskas, cov khoom noj kho mob yog cov khoom tshwj xeeb uas tswj hwm los ntawm FDA.

Hauv Tebchaws Europe, ib pawg zoo sib xws hu ua "Foos for Special Medical Purposes" (FSMPs) yog them los ntawm Cov Khoom Noj rau Kev Siv Khoom Noj tshwj xeeb thiab tswj hwm los ntawm European Commission (EC).
Xyoo 1988 FDA tau ua cov kauj ruam los txhawb kev txhim kho cov khoom noj kho mob los ntawm kev muab khoom plig rau menyuam ntsuag.
- Cov kev cai hloov pauv no txo cov nqi thiab lub sijhawm cuam tshuam nrog kev nqa cov zaub mov kho mob mus rau kev ua lag luam, vim tias ua ntej cov khoom noj kho mob tau kho raws li cov tshuaj siv tshuaj.
- Cov zaub mov kho mob tsis tas yuav raug tshuaj xyuas ua ntej lossis kev pom zoo los ntawm FDA.Tsis tas li ntawd, lawv raug zam los ntawm cov ntawv sau npe rau kev thov kev noj qab haus huv thiab kev thov cov ntsiab lus ntawm cov khoom noj raws li Txoj Cai Khoom Noj Khoom Noj thiab Kev Kawm Ntawv Xyoo 1990.
  - Tsis zoo li cov khoom noj khoom haus, uas txwv tsis pub ua tus kab mob thov thiab npaj rau cov tib neeg noj qab haus huv, cov zaub mov kho mob yog npaj rau cov kab mob tshwj xeeb.
  - Cov ntaub ntawv hais txog kab mob yuav tsum tau txais kev txhawb nqa los ntawm cov ntaub ntawv pov thawj scientific uas ua pov thawj ntawm kev tswj hwm kev noj zaub mov zoo ntawm tus kab mob.
  - Tag nrho cov khoom xyaw yuav tsum tau tso cai rau cov khoom noj ntxiv lossis cais ua GRAS.

Teb Chaws Asmeskas FDA xaiv cov zaub mov kho mob ua ib pawg ntawm cov tshuaj uas npaj rau kev tswj hwm kev noj haus ntawm ib qho mob lossis kab mob.Cov txheej txheem tshwj xeeb tsim nyog kom tau txais kev tso npe FDA no suav nrog cov khoom yuav tsum yog:
- Ib qho khoom noj tshwj xeeb rau kev noj qhov ncauj lossis nkag mus;
- Rau kev tswj xyuas kev noj haus ntawm ib qho kev kho mob tshwj xeeb, kab mob lossis kev txawv txav uas muaj cov khoom noj khoom haus tshwj xeeb;
- Ua nrog Feem Ntau Pom Zoo Raws Li Kev Nyab Xeeb (GRAS) cov khoom xyaw;
- Ua raws li FDA cov cai uas hais txog kev sau npe, cov khoom thov thiab

kev tsim khoom.

Raws li kev kho mob qeb, cov zaub mov kho mob txawv ntawm cov tshuaj thiab tshuaj ntxiv.
- Cov ntawv sau yuav tsum suav nrog cov kab lus, "yuav tsum siv nyob rau hauv kev saib xyuas kev kho mob," vim tias cov khoom noj kho mob tau tsim nyob rau hauv kev tsim khoom nruj thiab tswj xyuas cov txheej txheem siab.

Cov khoom noj kho mob puas yog qhov kev sib tw loj tom ntej rau cov khoom ntim khoom noj?

Cov cib fim hauv ntu khoom noj kho mob tau loj tuaj;kev lag luam tau kwv yees tias muaj nqis txog $ 15 billion, raws liCovPhab ntsaTxoj kev Phau ntawv.
Cov tuam txhab zaub mov loj, suav nrog Nestle thiab Hormel, tab tom nqis peev hauv R & D thiab cov khoom lag luam kom tau raws li kev xav tau kev kho mob thiab khoom noj khoom haus.
- Nestle tau tshaj tawm ib$500 lab pob nyiaj siv los txhawb kev tshawb fawb txog khoom noj khoom haus txog 2021.
- Raws li qhov kev sib tw, tau txais txoj cai lij choj thiab kev ntseeg siab hauv txoj haujlwm kho mob yuav zoo li qhov tseem ceeb
  - Cov neeg tsim khoom lag luam yuav tsum ua raws li kev tshawb fawb hauv kev tshawb fawb txog kev kho mob thiab muaj peev xwm txuas nrog cov tsev kawm tshawb fawb kom tau koom nrog, los txhawb kev tshawb fawb lossis kom tau txais kev paub tseem ceeb.

Cov piv txwv tshwj xeeb ntawm cov khoom noj kho mob muag thiab lawv qhov kev thov

Axona (caprylic triglyceride)-Alzheimer tus kab mob[5]
- Banatrol Plus (txiv tsawb flakes /Bimunogalacto-oligosaccharide,raws plab [6]
- Deplin (l-methylfolate)-kev nyuaj siab [7]
- Fosteum (genistein aglycone / citrated zinc bisglycinate / cholecalciferol)

-osteopenia thiabosteoporosis [8]

Limbrel (flavocoxid)-osteoarthritis [9]
Metanx (L-methylfolate calcium / pyridoxal 5'- phosphate / methylcobalamin) -ntshav qab zib neuropathy [10]
Theramine (l-arginine, 5-htp, histidine, l-glutamine) -myalgia [11]

PEA: Self-Affirmed GRAS (cov khoom noj khoom haus tshuaj)

Micronized PEA yog npaj los siv los ua cov khoom noj kho mob rau covKev noj haus kev tswj hwm ntawm cov txheej txheem metabolic hauv qab qhov mob-kho mob ntev, angiogenesis, thiab kab mob raum thiab physiological mechanisms hauv qabneuroprotectivethiab retinativ thaiv cov teebmeemof PEA.
PEApom zooto tsuas yog siv raws li kev kho mob kev saib xyuas.
PEAyog npaj rau kev siv ntawm ib koob tshuaj txhua hnub ntawm 400 mg / hnub rau 800 mg / hnub.Kev siv ib txwm yuav tsum yog pib koob tshuaj txog li 400 mg BID rau 3 - 4 hnub thiab noj tshuaj ntawm 300 mg BID rau txog 1 xyoos.PEA tsis pom zoo rau cov poj niam cev xeeb tub thiab lactating, menyuam yaus thiab cov hluas.Tsis tas li ntawd, PEA yuav tsis siv rau hauv cov zaub mov zoo tib yam rau cov pej xeem.

Post lub sij hawm: Oct-15-2019

Palmitoylethanolamide PEA

Pain Res Kho Mob. Xyoo 2014; 2014: 849623.

Sci Rep. Peb Hlis 23, 2017, 7(1): 375.

FDA ntawm Medical Food

• Hauv Teb Chaws Asmeskas, cov khoom noj kho mob yog cov khoom tshwj xeeb uas tswj hwm los ntawm FDA.