Huperzine A 98%

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  • Huperzine A 98%

Short Description:

Huperzine A has been found to have benefits of reversing or attenuating cognitive deficits in a broad range of animal models. Clinical trials have demonstrated that Huperzine A relieves memory deficits in aged subjects, patients with benign senescent forgetfulness, Alzheimer’s disease and vascular dementia, with minimal peripheral cholinergic side effects compared with other acheis in use.

Huperzia serrata is luxuriant plants, it has the total of eight varieties of medicinal plants in China.China is the biggest wild sugihara. Huperzine A extracted from a club moss (Huperzia serrata), is a sesquiterpene alkaloid and a powerful and reversible inhibitor of acetylcholinesterase (AChE) with on- and off-rates.

Huperzia serrata extract has been used in China for centuries for the treatment of swelling, fever and blood disorders. Huperzia serrata has demonstrated both memory enhancement in animal and clinical trials and neuroprotective effects.

Huperzia serrata has potent pharmacological effects and, particularly since long-term safety has not been determined, it should only be used with medical supervision. Huperzia serrata extract may have some effectiveness in Alzheimer’s disease and age-related memory impairment. Huperzia serrata extract has been used to treat fever and some inflammatory disorders, but there is no credible scientific evidence to support these uses.


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
  • E-mail:: info@trbextract.com
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    Product Detail

    Product Tags

    Product Name:Huperzine A 98%

    Latin Name:huperzia serrata (thunb) trev

    Specification:98% by HPLC

    Botanic Source:Huperzia Serrata Extract

    CAS No:120786-18-7

    Plant Part Used:Leaf

    Colour:Yellow brown to white powder with characteristic odor and taste

    GMO Status:GMO Free

    Packing: in 25kgs fiber drums

    Storage:Keep container unopened in cool, dry place,Keep away from strong light

    Shelf Life:24 months from date of production

    Huperzine A 98% Product Description

    Product Overview

    Huperzine A 98% is a highly purified, synthetic or naturally sourced compound (derived from Huperzia serrata), renowned for its acetylcholinesterase (AChE) inhibitory activity and neuroprotective properties . With a molecular formula of C15H18N2O and CAS No. 102518-79-6, it is widely studied for cognitive enhancement and potential applications in neurodegenerative disorders like Alzheimer’s disease .

    Key Features

    1. High Purity & Quality Control
      • Purity: ≥98% (confirmed by HPLC, TLC, and UHPLC-QTOF-MS analysis) .
      • Solubility: Soluble in DMSO (105 mg/mL), methanol (10 mg/mL), and ethanol .
      • Storage: Stable at -20°C in sealed containers; avoid moisture and light .
    2. Mechanism of Action
      • AChE Inhibition: Reversibly inhibits acetylcholinesterase, increasing acetylcholine levels to enhance memory and cognitive function .
      • Neuroprotection: Reduces glutamate-induced neuronal cell death and mitigates mitochondrial dysfunction caused by Aβ42 oligomers .
    3. Clinical Relevance
      • Alzheimer’s Disease: Meta-analyses of randomized trials show improvements in MMSE, ADL, and HDS scores, though results vary by study design .
      • Safety Profile: No severe adverse events reported in clinical trials, but caution is advised due to limited long-term data .

    Applications

    • Pharmaceuticals: Formulated for dementia treatment and cognitive support .
    • Dietary Supplements: Used in nootropics for memory enhancement .
    • Research: Investigated for neuroprotection against organophosphates and glutamate toxicity .

    Safety & Handling

    GHS Hazard Statements :

    • H301+H311+H331: Toxic if swallowed, in contact with skin, or inhaled.
    • H315/H319: Causes skin/eye irritation.
    • H335: May cause respiratory irritation.

    Precautionary Measures:

    • Personal Protection: Wear gloves, goggles, and respiratory masks. Avoid dust formation .
    • First Aid: Rinse eyes/skin immediately; seek medical attention if ingested .

    Quality Assurance

    • Analytical Methods: Validated via UHPLC-QTOF-MS for precise quantification and batch consistency .
    • Synthesis: Advanced 8-step synthesis achieves 25-45% yield, ensuring scalable production .

    Ordering & Supply

    • Form: White crystalline powder .
    • Packaging: Available in 20mg to 25kg batches .

    Why Choose Our Product?

    • Compliance: Meets GHS 1.0 and OSHA standards for safe handling .
    • Research-Backed: Supported by over 20 clinical trials and molecular docking studies .
    • Global Shipping: Reliable delivery to EU/US markets with COA provided .

    Keywords: Huperzine A 98%, Acetylcholinesterase Inhibitor, Alzheimer’s Support, Neuroprotective Agent, Nootropic Supplement, GHS-Compliant

     

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