Icariin Powder 98%

Short Description:

Icariin is one of the major flavonoids of the herb Epimedium, which has long been used in Tranditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Research has shown that icariin should be an effective component for the bone-strengthening activity of the herb Epimedium, and one of the possible mechanisms for this activity is to stimulate the proliferation and enhance the osteogenic differentiation of marrow stromal cells. Icariin is reported to prevent and treat sexual dysfunction related diseases and improve the use of vasoconstriction. Icariin is used to prepare angiotensin converting enzyme inhibitor medicines, which can be used to treat hypertension-complicated coronary diseases.

Epimedium also is known as Horny Goat Weed or Yin Yang Huo, ti’s a genus of about 60 species of herbaceous flowering plants in the family Berberidaceae. The large majority are endemic to southern China, with further outposts in Europe, and central, southern and eastern Asia. Usually, make the Epimedium brevicornum and epimedium sagittatum as the raw material because of their high function.
Epimedium Extract Icariin is extracted from the Epimedium leaves. Icariin offers effective support in conditions that result from kidney yang deficiency, such as impotence and chronic prostatitis in males, and irregular menses, infertility, and menopause in females. Epimedium Extracts Icariin help to regulate both androgenic and estrogenic reproductive functions. have aphrodisiac properties in males, increasing the production of sperm, stimulating the sensing nerves, and indirectly promoting sexual desire. Epimedium Extracts Icariin is ideal for adding to sexual enhancement formulas.

FOB Price: US 5 - 2000 / KG

Min.Order Quantity: 1 KG

Supply Ability: 10000 KG/per Month

Port: Shanghai /Beijing

Payment Terms: L/C,D/A,D/P,T/T,O/A

Shipping Terms: By sea/By Air/By Courier

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Product Detail

Product Tags

Product Name:Icariin 98%

Specification：98% by HPLC

Botanic Source:Epimedium Extract/Horny Goat Weed Extract

CAS No:489-32-7

Plant Part Used:dried stems and leaf

Colour:Yellow brown to white powder with characteristic odor and taste

GMO Status:GMO Free

Packing: in 25kgs fiber drums

Storage:Keep container unopened in cool, dry place,Keep away from strong light

Shelf Life:24 months from date of production

Epimedium flavonoid: icariin

Icariin powder (heteronym Icariin) is the main active ingredient of Epimedium, which is 8-isopentenyl flavonoids compound extracted from the stems and leaves of Epimedium brevicornum Maxim, Epimedium sagittatum Maxim, Epimedium pubescens Maxim and Epimedium koreanum Nakai.

Horny goat weed extract Icariin structure

What is Epimedium?

Epimedium is a perennial plant. It belongs to the family Berberidaceae and blooms “spider-like” flowers in spring.

Epimedium leaves are famous in Traditional Chinese Medicine by several alternative names, including Xian LingPi, Horny Goat Weed, Barrenwort, and Epimedium Grandiflorum.

The Classic of Shennong Materia Medica claims its effects as tonifying kidney Yang, strengthening muscles and bones, and removing wind and dampness.

Epimedium plant

Epimedium grandiflorum active ingredients

Horny goat weed extract contains flavonoids, lignans, alkaloids, phytosterol, vitamin E, etc.

The aboveground part of the barrenwort plant mainly contains flavonoids, while the underground part mainly contains flavonoids and alkaloids.

Icariin specifications

Icariin 10%, 20%, 98%

Icariin benefits and action mechanisms

Anti-tumor

Icariin and its derivatives mainly inhibit the growth of tumors through the induction of apoptosis by targeting multiple signaling pathways. Cell cycle arrests also occur through the downregulation of the expression of cell cycle regulatory proteins. Besides, there are anti-angiogenesis, anti-metastasis, and immunomodulation.

Anti cancer mechanisms of icariin and its derivatives

Bone resorption

Icariin promotes bone formation by stimulating the osteogenic differentiation of BMSCs (bone marrow-derived mesenchymal stem cells) while inhibiting osteoclastogenic differentiation and the bone resorption activity of osteoclasts. Furthermore, icariin is more potent than other flavonoid compounds in promoting osteogenic differentiation and maturation of osteoblasts.

PDE5 inhibitor

Several animal studies have found that icariin does inhibit PDE5, then allows the penis to fill with blood to form an erection. Another study found that the mechanism of icariin on penile erection was related to its ability to increase the concentration of CGMP in the smooth muscle of the penis and enhance the relaxation of the smooth muscle of the penis.

icariin as a PDE5 inhibitor

Anti-aging

Epimedium can improve the body’s immunity by influencing the secretion of mesophile cytokines in the body, promoting the proliferation of lymphocytes, improving the activity of cell regulation, activating the immune function of the thymus, and enhancing the ability of the thymus and spleen cells to produce interleukin.

Blood pressure

Epimedium can improve cardiovascular and cerebrovascular functions by dilating blood vessels and inhibiting the intracellular calcium flow of vascular smooth muscle, increasing coronary artery flow, protecting myocardial ischemia, inhibiting thrombus, promoting platelet generation, and enhancing platelet aggregation.

Female estrogen

Icariin can reduce the levels of FSH and luteinizing hormone, increase the level of estradiol, up-regulate the expression of anti-Mullerian hormone in the ovary, increase the ratio of Bcl-2 /Bax in ovarian tissue, improve the development of ovarian follicles in aging mice, inhibit follicular atresia, and improve their fertility.

Relief pain

Icarian inhibits NF-κB inhibitory protein α degradation and NF-κB, activation, up-regulates peroxisome proliferators-activated receptors (PPARs) α and γ protein levels and alleviates neuroinflammation.

Icariin VS other PDE5 inhibitors

Icariin vs. Viagra

Icariin has an IC50 for PDE5 of 5.9 micromolar, while sildenafil has an IC50 of 75 nanomolar. They are converting both to nanomolar (nM), 5900 nM for Icariin, to have the same effect as 75 nM sildenafil!

Icariin vs. Yohimbine

Yohimbine is one of the few agents that effectively support fat reduction, which is still in legal circulation. It also has an unexpected side effect of increasing libido and erectile strength. Yohimbine blocks presynaptic alpha-2 adrenergic receptors. It has a similar impact on peripheral blood vessels as reserpine but is weaker and lasts shorter.

Icariin vs. Tribulus

Tribulus Terrestris saponin is a testosterone stimulant derived from the fruit of Tribulus Terrestris. The function of Tribulus Tribulus in the human body analysis system is to stimulate the secretion of pituitary luteinizing hormone, which promotes testosterone secretion. Then the blood testosterone level in the human body is improved.

Horny Goat Weed(Icariin) Supplement stack

Icariin and resveratrol
Icariin and maca extract
Icariin and L-arginine HCL
Icariin and Tongkat Ali
Icariin and Panax Ginseng Extract
Icariin and Yohimbine

Bioavailability of oral icariin

We are still determining the actual bioavailability of oral icariin 98% now. But according to many brands’ tests and research, we got the recommended dosage:

Boosting testosterone, 100mg~400mg/day

Dietary supplement, 25mg~150mg/day

Epimedium 98% side effects

There is not enough research about the safety of Icariin 98% for pregnant and breastfeeding women. Don’t take it if you have any underlying medical conditions, such as bleeding disorders, hormone-sensitive conditions, or low blood pressure. Icariin is not for patients with Yin deficiency and fire exuberance and has symptoms such as fever of hands and feet and night sweats.

It may lead to precocious puberty in children.

Icariin Powder 98% | Natural Sexual Health & Bone Density Enhancer

CAS No.: 489-32-7 | Purity: 98% HPLC | Plant-Sourced from Epimedium | Non-GMO

Product Overview

Icariin Powder 98% is a premium flavonoid extracted from Epimedium (Horny Goat Weed), renowned for its dual benefits in supporting sexual vitality, bone health, and anti-aging. With 98% purity verified by HPLC, this bioactive compound is ideal for dietary supplements, functional foods, nutraceuticals, and clinical research. Backed by over 300 scientific studies, it addresses modern health priorities such as hormonal balance, osteoporosis prevention, and cellular longevity.

Key Benefits

✅ Sexual Health & Hormonal Support

Enhances nitric oxide production to improve blood flow and erectile function.
Modulates testosterone and estrogen levels for balanced hormonal health.

✅ Bone Density & Joint Protection

Stimulates osteoblast activity to combat osteoporosis and promote bone regeneration.
Reduces inflammation in joints, studied for osteoarthritis support.

✅ Anti-Aging & Antioxidant Defense

Activates AMPK/SIRT1 pathways to delay cellular aging and improve mitochondrial function.
Neutralizes free radicals (ROS) and protects against oxidative stress.

✅ Neuroprotection & Cognitive Enhancement

Crosses the blood-brain barrier to reduce neuroinflammation and enhance memory (preclinical data).

✅ Research-Backed Applications

Investigated for cardiovascular health, anti-depressant effects, and cancer chemoprevention.

Applications

Dietary Supplements
- Capsules, tablets, or powders for libido enhancement, bone strength, and energy support.
- Suggested dosage: 50–300 mg/day (consult healthcare provider).
Functional Foods & Beverages
- Added to vitality drinks, hormone-balancing blends, or senior health formulas.
Cosmetic Formulations
- Anti-aging serums targeting collagen synthesis and skin elasticity.
Pharmaceutical R&D
- Investigational ingredient for osteoporosis drugs, cognitive enhancers, and oncology therapies.