N'afọ 1913, Prọfesọ Kylin bụ́ ọkà mmụta sayensị Sweden chọtara akụkụ ahụ na-akpụ akpụ nke kelp, fucoidan, na Mahadum Uppsala.A makwaara dị ka "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", wdg, aha Bekee bụ "Fucoidan".Ọ bụ ihe polysaccharide na-agbaze mmiri nke nwere fucose nwere otu sulfate.Ọ na-adịkarị na slime elu nke algae na-acha aja aja (dị ka ahihia mmiri, spores wakame, na kelp).Ọdịnaya dị ihe dịka 0.1%, ọdịnaya dị na kelp akọrọ bụ ihe dịka 1%.Ọ bụ ihe bara uru nke ahịhịa mmiri na-arụ ọrụ.
Nke mbụ, ịdị irè nke fucoidan
Japan ugbu a bụ obodo nwere ogologo ndụ ogologo n'ụwa.N'otu oge ahụ, Japan nwere otu n'ime ọnụ ọgụgụ kasị ala nke ọrịa na-adịghị ala ala.Dị ka ndị ọkachamara n'ihe banyere nri si kwuo, otu n'ime ihe kacha mkpa maka ahụ ike nke ndị Japan nwere ike metụtara iri nri ahịhịa mmiri mgbe niile.Fucoidan dị na algae agba aja aja dị ka kelp bụ ihe na-arụ ọrụ nwere ọrụ dị iche iche physiological.Ọ bụ ezie na Prọfesọ Kylin chọtara ya na 1913, ọ bụ na 1996 ka e bipụtara Fucoidan na Nzukọ Ọgbakọ Ọrịa Cancer nke Japan nke 55.Akụkọ ahụ na-ekwu na "nwere ike ịkpalite apoptosis cell cancer" akpalitela nchegbu zuru ebe niile na obodo agụmakwụkwọ ma mee ka nyocha dị elu.
Ka ọ dị ugbu a, ndị na-ahụ maka ahụike na-eme nyocha banyere ọrụ dị iche iche nke fucoidan, ma bipụtala ọtụtụ puku akwụkwọ na akwụkwọ akụkọ ahụike mba ụwa, na-akwado na fucoidan nwere ọrụ dị iche iche nke ndu, dị ka mgbochi tumor, na-eme ka eriri afọ, na antioxidant , mee ka mgbochi ahụ dịkwuo mma. , antithrombotic, ala ọbara mgbali, antiviral mmetụta.
(I) Fucoidan na-eme ka ọrụ eriri afọ dịkwuo mma
Helicobacter pylori bụ helical, microaerobic, gram-adịghị mma bacilli nke na-achọsi ike maka ọnọdụ uto.Ọ bụ naanị ụdị microbial mara ugbu a ka ọ dị ndụ n'ime afọ mmadụ.Ọrịa Helicobacter pylori na-akpata gastritis na tract digestive.Ulcers, lymphoproliferative gastric lymphomas, wdg, nwere adịghị mma amụma maka ọrịa kansa afọ.
Usoro ndị na-akpata ọrịa H. pylori gụnyere: (1) adhesion: H. pylori nwere ike ịgafe dị ka akwa oyi akwa ma na-arapara na cell epithelial gastric;(2) wepụ gastric acid maka abamuru nke nlanarị: H. pylori na-ahapụ urease, na Urea n'ime afo na-emeghachi omume iji mepụta gas amonia, nke na-ewepụ acid gastric;(3) na-ebibi mucosa gastric: Helicobacter pylori na-ewepụta nsị VacA ma na-emebi mkpụrụ ndụ elu nke mucosa gastric;(4) na-emepụta chloramine nsi: gas amonia na-emebi mucosa gastric ozugbo, yana oxygen na-arụ ọrụ mmeghachi omume na-emepụta chloramine na-egbu egbu karị;(5) Na-ebute nzaghachi mkpali: Iji chebe megide Helicobacter pylori, ọnụ ọgụgụ dị ukwuu nke ọbara ọcha na-ezukọ na mucosa gastric iji mepụta nzaghachi mkpali.
Mmetụta nke fucoidan megide Helicobacter pylori gụnyere:
1. Mgbochi nke ịba ụba Helicobacter pylori;
N'afọ 2014, ndị otu Yun-Bae Kim na-eme nchọpụta na Chungbuk National University dị na South Korea bipụtara nchọpụta na-egosi na fucoidan nwere mmetụta antibacterial dị mma, na fucoidan na ntinye nke 100µg / mL nwere ike igbochi mgbasa nke H. pylori kpamkpam.(Lab Anim Res2014: 30 (1), 28-34.)
2. Gbochie adhesion na mbuso agha nke Helicobacter pylori;
Fucoidan nwere otu sulfate ma nwee ike ijikọ na Helicobacter pylori iji gbochie ya ịrapara na sel epithelial gastric.N'otu oge ahụ, Fucoidan nwere ike igbochi mmepụta urease ma chebe gburugburu acidic nke afọ.
3. Mmetụta antioxidant, belata mmepụta nsị;
Fucoidan bụ ezigbo antioxidant, nke nwere ike mebie ikuku oxygen ngwa ngwa ma belata mmepụta chloramine na-emerụ ahụ.
4. Mmetụta mgbochi mkpali.
Fucoidan nwere ike igbochi ọrụ nke lectin ahọpụtara, mmeju na heparanase, ma belata nzaghachi mkpali.(Helicobacter, 2015, 20, 89–97.)
Tụkwasị na nke ahụ, ndị nchọpụta ahụ chọpụtara na fucoidan nwere mmetụta dị ukwuu n'ịkwalite ahụike nke eriri afọ ma nwee mmetụta nhazi ụzọ abụọ na eriri afọ: meziwanye afọ ntachi na enteritis.
Na 2017, otu ndị nyocha sitere n'aka Prọfesọ Ryuji Takeda nke Mahadum Kansai nke Welfare Sciences na Japan mere ọmụmụ ihe.Ha họpụtara ndị ọrịa 30 nwere afọ ntachi ma kee ha ụzọ abụọ.Enyere otu nnwale ahụ 1 g nke fucoidan ma nye ndị otu njikwa ebebo.Ọnwa abụọ mgbe ule ahụ gasịrị, a chọpụtara na ọnụ ọgụgụ nke ụbọchị nkwụsị kwa izu n'ime otu ule na-ewere fucoidan mụbara site na nkezi nke ụbọchị 2.7 ruo ụbọchị 4.6, na ụda nsị na ịdị nro mụbara nke ukwuu.(Nri na-arụ ọrụ na ahụike na ọrịa 2017, 7: 735-742.)
Na 2015, otu Prọfesọ Nuri Gueven nke Mahadum Tasmania, Australia, chọpụtara na fucoidan nwere ike imeziwanye enteritis na ụmụ oke n'ụzọ dị irè, n'otu aka ahụ, ọ nwere ike inyere ụmụ oke aka iweghachi ibu ma na-abawanye ike nke nsị;n'aka nke ọzọ, ọ nwere ike ibelata ibu nke colon na splin.Na-ebelata mbufụt na ahụ.(PLoS ONE 2015, 10: e0128453.)
B) Mmetụta antitumor nke fucoidan
Nnyocha na mmetụta antitumor nke fucoidan ugbu a bụ ihe kachasị emetụ n'ahụ gburugburu agụmakwụkwọ, na enwetala ọtụtụ nsonaazụ nyocha.
1. Iwu nke usoro okirikiri tumor
Na 2015, Prọfesọ Lee Sang Hun na ndị ọzọ na Mahadum Soonchunhyang dị na South Korea na ndị nchọpụta ndị ọzọ chọpụtara na fucoidan na-egbochi okwu cyclin Cyclin na cyclin kinase CDK na mkpụrụ ndụ tumo site na ịhazi usoro uto nke mkpụrụ ndụ cancer colon mmadụ, na-emetụta mitosis nkịtị. mkpụrụ ndụ tumo.Stagnate mkpụrụ ndụ tumo na oge tupu mitotic ma gbochie mmụba cell tumor.(Akụkọ Nkà Ọgwụ Molecular, 2015, 12, 3446.)
2.Induction nke tumor cell apoptosis
N'afọ 2012, otu nnyocha ndị otu Quan Li na-eme nchọpụta na Mahadum Qingdao bipụtara chọpụtara na fucoidan nwere ike ime ka mgbaàmà apoptosis nke mkpụrụ ndụ tumor-Bax apoptosis protein mebie DNA na mkpụrụ ndụ cancer ara, nchịkọta chromosome, ma mee ka apoptosis na-enweghị atụ nke mkpụrụ ndụ tumo., gbochiri uto mkpụrụ ndụ tumo na ụmụ oke.(Plos One, 2012, 7, e43483.)
3.Igbochi metastasis tumor cell
Na 2015, Chang-Jer Wu na ndị ọzọ na-eme nchọpụta si National Taiwan Ocean University bipụtara nnyocha na-egosi na fucoidan nwere ike dịkwuo anụ ahụ inhibitory factor (TIMP) okwu na ala-achịkwa matrix metalloproteinase (MMP) okwu, si otú na-egbochi tumor cell metastasis.(Mar. Ọgwụ 2015, 13, 1882.)
4.Igbochi akpụ angiogenesis
N'afọ 2015, ndị otu nyocha Tz-Chong Chou na Taiwan Medical Center chọpụtara na fucoidan nwere ike belata mmepụta nke vascular endothelial growth factor (VEGF), na-egbochi neovascularization nke etuto ahụ, bepụ ihe oriri na-edozi ahụ nke etuto ahụ, na-agụụ etuto ahụ. oke oke igbochi mgbasa na metastasis nke mkpụrụ ndụ etuto.(Mar. Ọgwụ 2015, 13, 4436.)
5. Mee ka usoro ahụ ji alụso ọrịa ọgụ rụọ ọrụ
N'afọ 2006, Prọfesọ Takahisa Nakano nke Mahadum Kitasatouniversity dị na Japan chọpụtara na fucoidan nwere ike ịkwalite ihe nchebe nke ahụ ma jiri usoro ahụ ji alụso ọrịa ọgụ gbuo mkpụrụ ndụ kansa kpọmkwem.Mgbe fucoidan batara n'ime eriri afọ, mkpụrụ ndụ na-alụso ọrịa ọgụ nwere ike ịmata ya, na-emepụta ihe mgbaàmà na-eme ka usoro ahụ ji alụso ọrịa ọgụ rụọ ọrụ, ma mee ka mkpụrụ ndụ NK, mkpụrụ ndụ B, na T cell rụọ ọrụ, si otú ahụ na-emepụta ọgwụ nje na-ejikọta na mkpụrụ ndụ cancer na T cell na-egbu ọrịa cancer. mkpụrụ ndụ.igbu egbu kpọmkwem nke mkpụrụ ndụ kansa, na-egbochi uto mkpụrụ ndụ kansa.(Planta Medica, 2006, 72, 1415.)
Mmepụta nke Fucoidan
Ọdịnaya nke otu sulfate dị n'ụdị molekụla nke fucoidan bụ ihe ngosipụta dị mkpa nke na-ekpebi ọrụ physiological ya, yana ọ bụkwa ọdịnaya dị mkpa nke mmekọrịta-mmekọrịta nke fucoidan.Ya mere, ọdịnaya nke otu sulfate bụ ihe dị mkpa maka ịlele ịdịmma fucoidan na mmekọrịta-mmekọrịta.
N'oge na-adịbeghị anya, ndị na-ahụ maka nri na ọgwụ ọjọọ kwadoro ikike mmepụta nri fucoidan polysaccharide ma nye ya Qingdao Mingyue Seaweed Group, nke pụtara na Mingyue Seaweed Group anọwo na-arụ ọrụ nke ọma n'oké osimiri ihe karịrị afọ 50.Nweta asambodo gọọmentị.A na-akọ na Mingyue Seaweed Group arụwo ahịrị mmepụta fucoidan na mmepụta kwa afọ nke tọn 10.N'ọdịnihu, ọ ga-enye egwuregwu zuru oke na mmetụta "ọgwụ na nri homology" ma na-egbuke egbuke na ubi nri na-arụ ọrụ nke nnukwu ụlọ ọrụ ahụike.
Mingyue Seaweed Group, dị ka ụlọ ọrụ akwadoro maka mmepụta nke nri fucoidan, nwere ahụmahụ mmepụta ọtụtụ afọ.Fucoidan nke ọ mepụtara bụ ngwaahịa nkwalite teknụzụ nke mbụ kelp concentrate/ ntụ ntụ.Iji nri dị elu-ọkwa agba aja aja algae dị ka akụrụngwa, n'ihu ịdị ọcha na nkewa dabere na eke mmịpụta technology, ọ bụghị nanị na-eme ka ekpomeekpo na uto nke ngwaahịa, ma na-abawanye fucoidan polysaccharide ọdịnaya (dị ọcha), nke a pụrụ iji na. ọtụtụ ubi dị ka nri na-arụ ọrụ na nri ahụike..Ọ nwere uru nke ịdị ọcha ngwaahịa dị elu na ọdịnaya dị elu nke otu ọrụ;Mwepụ ọla dị arọ, nchekwa dị elu;desalination na fishiness, uto na ekpomeekpo mma.
Ngwa nke Fucoidan
Ka ọ dị ugbu a, enwere ọtụtụ ngwaahịa fucoidan emepụtara ma tinye ya na Japan, South Korea, United States na mba ndị ọzọ, dị ka fucoidan gbadoro anya, fucoidan wepụ raw capsules, na mmanụ ahịhịa mmiri super fucoidan.Nri na-arụ ọrụ dị ka Seaweed Group's Qingyou Le, Rockweed Treasure, Brown Algae Osisi ihe ọṅụṅụ.
N’afọ ndị na-adịbeghị anya, “Nkọkọ banyere ọnọdụ nri ndị bi na China na-eri nri na ọrịa na-adịghị ala ala” na-egosi na usoro ihe oriri nke ndị China agbanweela, ọnụ ọgụgụ nke ọrịa na-adịghị ala ala na-arị elu.Nnukwu ọrụ ahụike hiwere isi na “ịgwọ ọrịa” adọtala uche dị ukwuu.Iji fucoidan na-emepụta ma na-emepụta ihe oriri ndị na-arụ ọrụ ga-enyocha n'ụzọ zuru ezu uru bara uru nke fucoidan na-enye ndụ na ahụike, nke dị oke mkpa maka mmepe nke "ọgwụ ahụike na nri homology" nnukwu ụlọ ọrụ ahụike.
Njikọ ngwaahịa: https://www.trbextract.com/1926.html
Oge nzipu: Mar-24-2020