Product Name:Ipriflavone 98%
Other Names: 7-Isoproxyisoflavone
Specification：98% by HPLC
CAS Registry Number: 35212-22-7
CAS Name: 7-(1-Methylethoxy)-3-phenyl-4H-1-benzopyran-4-one
Additional Names: 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one; 7-isopropoxy-3-phenylchromone; 7-isopropoxyisoflavone
Manufacturers’ Codes: FL-113; TC-80
Trademarks: Iprosten (Takeda); Osten (Takeda); Osteofix (Chiesi); Yambolap (Chinoin)
Molecular Formula: C18H16O3
Molecular Weight: 280.32
Percent Composition: C 77.12%, H 5.75%, O 17.12%
Properties: Crystals from acetone, mp 115-117°.
Melting point: mp 115-117°
Colour:white powder with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Ipriflavone 98% Product Description
Product Overview
Ipriflavone 98% is a high-purity synthetic isoflavone derived from soy daidzein, specifically formulated to support bone health. With the chemical formula C₁₈H₁₆O₃ (CAS: 35212-22-7), this compound is standardized to ≥98% purity and stored at -20°C to ensure stability and efficacy. Clinically studied for decades, it targets bone metabolism by inhibiting resorption and promoting mineralization, making it a key supplement for osteoporosis management.
Mechanism of Action
Ipriflavone works through dual mechanisms:
- Anti-Resorptive Effects: Binds to nuclear receptors in preosteoclastic cells, reducing bone breakdown without estrogenic activity on breast or uterine tissues.
- Osteogenic Effects: Stimulates osteoblast differentiation, enhancing collagen synthesis and alkaline phosphatase activity to build bone matrix.
Clinical Efficacy
- Postmenopausal Osteoporosis: Over 60 human trials, including double-blind studies, demonstrate that 600 mg/day (divided into 200 mg thrice daily) combined with 1,000 mg calcium preserves or increases bone mineral density (BMD) in women aged 50–65, outperforming calcium alone.
- Synergy with Estrogen: Enhances low-dose estrogen therapy (0.15–0.30 mg/day), reducing bone loss risk while minimizing estrogen side effects.
- Comparable to Pharmaceuticals: In a 12-month trial, Ipriflavone increased BMD by 4.3% vs. 1.9% with salmon calcitonin, a common osteoporosis drug.
Key Benefits
- Prevents Surgical/Drug-Induced Bone Loss: Effective against bone loss from glucocorticoids or GnRH agonists (e.g., Lupron), with studies showing no BMD decline in treated groups vs. significant placebo-group losses.
- Supports Multiple Bone Disorders: Benefits Paget’s disease, renal osteodystrophy, and hyperparathyroidism.
- Safe Long-Term Use: Evaluated in 2,769 patients over 3,132 patient-years, with adverse events (14.5%) comparable to placebo (16.1%).
Dosage & Administration
- Recommended Dose: 600 mg/day, divided into 200 mg thrice daily or 300 mg twice daily.
- Optimal Use: Pair with 1,000 mg calcium and vitamin D for enhanced bone density.
Safety & Precautions
- Common Side Effects: Mild gastrointestinal discomfort (e.g., nausea, diarrhea), often linked to calcium co-administration.
- Lymphocytopenia Risk: 13.2% of users may experience transient lymphocyte drops; monitoring is advised. Contraindicated in severe renal impairment.
- Drug Interactions: May interfere with warfarin or theophylline metabolism; consult healthcare providers before combining.
Quality Assurance
- Purity & Testing: Manufactured under strict HPLC protocols (UV detection at 246 nm), ensuring compliance with pharmacopeial standards.
- Solubility: Advanced cyclodextrin inclusion complexes improve bioavailability, addressing historical solubility limitations.
Why Choose Our Product?
Backed by over 150 preclinical and clinical studies, our Ipriflavone 98% offers a science-backed, cost-effective alternative to pharmaceuticals. Ideal for postmenopausal women, osteoporosis patients, and those on bone-depleting therapies, it combines efficacy with a well-tolerated profile.
Keywords: Osteoporosis treatment, Bone density, Ipriflavone clinical trials, Postmenopausal bone loss, Non-estrogenic bone support
