J-147 Powder

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  • J-147 Powder

Short Description:

J147 is J-147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J-147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

J-147 is a particularly potent orally active neuroprotectant derived primarily from curcumin, the active ingredient in turmeric. Unlike curcumin, it crosses the blood-brain barrier very successfully.

J-147 is a particularly potent orally active neuroprotectant derived primarily from curcumin, the active ingredient in turmeric. Unlike curcumin, it crosses the blood-brain barrier very successfully. Among them, J-147 works by binding to ATP synthase. Overproduction of ATP is associated with the aging process. In addition to increasing levels of the neurotransmitters NGF and BDNF, J-147 can control this. In addition, J-147 inhibits monoamine oxidase B and dopamine transporter. Promotes brain growth by increasing levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Most importantly, J-147 can promote the growth of new nerve cells, enhance the brain’s learning ability and memory, and improve cognitive function.


  • FOB Price: US 5 - 2000 / KG
  • Min.Order Quantity: 1 KG
  • Supply Ability: 10000 KG/per Month
  • Port: Shanghai /Beijing
  • Payment Terms: L/C,D/A,D/P,T/T,O/A
  • Shipping Terms: By sea/By Air/By Courier
  • E-mail:: info@trbextract.com
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    Product Detail

    Product Tags

    Product Name:J-147 Powder

    Other Name:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147, J147

    CAS No:1146963-51-0

    Assay:  99.0%Min

    Colour: White powder

    Packing:25kgs Drums

    Title: J-147 Powder: Neuroprotective Agent for Alzheimer’s Research & Anti-Aging Applications 
    Meta Description: Discover J-147 Powder, a curcumin-derived neuroprotective compound with proven efficacy in enhancing cognition, crossing blood-brain barrier, and targeting Alzheimer’s disease. Available in multiple specifications with global shipping.

    Product Highlights

    1. Neuroprotective Powerhouse
      • Orally active compound inhibiting MAO-B (EC50=1.88 μM) and dopamine transporter (EC50=0.649 μM)
      • Enhances dendritic spine density and memory in 6-month-old mice at 200ppm dietary concentration
      • Clinically tested Phase I trial for Alzheimer’s by Abrexa Pharmaceuticals & leading institutes
    2. Multi-Target Anti-Aging Mechanism
      • Binds to ATP synthase to regulate mitochondrial function
      • Increases NGF/BDNF neurotransmitters while blocking brain cell damage
      • Addresses vascular aging by preventing microvascular leakage in mouse brains
    3. Technical Specifications
      • CAS No.: 1146963-51-0 | Molecular Formula: C18H17F3N2O2
      • Purity: >99% | Solubility: 10 mM in DMSO
      • Available Sizes: 1mg-500mg bulk orders | 10mM/1mL solution

    Guidance:

    1. Keyword Integration
      • Primary: “neuroprotective supplement”, “Alzheimer’s research compounds”, “curcumin derivative powder”
      • Long-tail: “MAO-B inhibitor for cognitive enhancement”, “anti-aging mitochondrial support”
    2. Technical SEO Compliance
      • Structured data markup for chemical properties (CAS, EC50, molecular weight)
      • Cross-linking to related product pages (e.g., CAD-31 derivatives , TrkB agonists )
    3. User-Centric Design
      • Amazon-style navigation: Left-side classification + top search bar
      • Interactive spec comparison tables with MCE/TargetMol competitors

    Trust-Building Elements

    • Global Logistics: Same-day dispatch (China stock) + temperature-controlled shipping 
    • Research Backing: Cited by Salk Institute, Blanchette Rockefeller Neurosci Inst 
    • Safety Profile: No genotoxicity observed up to 90μM in CeeTox assays 
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