Luteolin Powder

Short Description:

Luteolin is a flavone chiefly found in vegetables and fruits . Moreover, it is isolated as a yellow crystalline compound with the chemical formula C15H10O6, a tetrahydroxyflavone in which the four hydroxy groups are present at positions 3′, 4′, 5, and 7 [9]. Its role in disease management by modulating various biological activities has been discussed. This compound has been proven to have antioxidant, anti-inflammatory, anti-apoptotic, and hepatoprotective properties [10,11]. The role of luteolin in cancer has been firmly established through extensive in vivo and in vitro studies that highlight its ability to modulate cell-signaling pathways. This review delves into the potential of luteolin as an anticancer agent by analyzing its ability to modulate various cell-signaling pathways.

FOB Price: US 5 - 2000 / KG

Min.Order Quantity: 1 KG

Supply Ability: 10000 KG/per Month

Port: Shanghai /Beijing

Payment Terms: L/C,D/A,D/P,T/T,O/A

Shipping Terms: By sea/By Air/By Courier

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Product Detail

Product Tags

Product Description: Luteolin 98% by HPLC
CAS No.: 491-70-3 | Molecular Formula: C₁₅H₁₀O₆ | Molecular Weight: 286.24

1. Overview

Luteolin, a naturally occurring flavonoid, is widely present in plants such as parsley, celery, green peppers, artichokes, rosemary, and olive oil . Known for its potent bioactivity, Luteolin 98% by HPLC is a high-purity extract standardized through advanced chromatographic techniques to ensure consistency and efficacy. This product meets the stringent demands of pharmaceutical, nutraceutical, and cosmetic industries, offering a versatile ingredient backed by scientific research .

2. Key Specifications

Purity: ≥98% by HPLC
Appearance: Light yellow to greenish powder
Ash Content: ≤5% (for External Purity ≥90%) or ≤13% (for External Purity ≥85%)
Solubility: Insoluble in water; soluble in organic solvents like DMSO
Storage: Store in a cool, dry place away from light

Purity Clarification

Normalization Purity: Refers to the proportion of Luteolin in the HPLC chromatogram (≥98%) .
External Purity: Calibrated against a reference standard (Sigma grade), indicating actual purity (85–95%) .
- Example: A batch with 13% ash achieves 85% external purity, while ≤5% ash allows ≥90% external purity .

3. Health Benefits and Mechanisms

3.1 Antioxidant Activity

Luteolin neutralizes free radicals by donating hydrogen atoms, protecting cells from oxidative stress linked to aging, cardiovascular diseases, and neurodegeneration . Studies show it scavenges superoxide anions and inhibits lipid peroxidation .

3.2 Anti-Inflammatory Effects

By suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-6) and inhibiting NF-κB and COX-2 pathways, Luteolin alleviates chronic inflammation in conditions like arthritis and pancreatitis . In murine models, it reduced pancreatic edema and inflammatory infiltration via HO-1 modulation .

3.3 Anticancer Properties

Luteolin induces apoptosis and cell cycle arrest in cancer cells while inhibiting metastasis and angiogenesis . Notable effects include:

Prostate & Breast Cancer: Suppresses proliferation by downregulating PI3K/Akt and ERK pathways .
Lung Cancer: Inhibits Nrf2, sensitizing cells to chemotherapy .
Liver Cancer: Reduces hepatic fibrosis and protects hepatocytes .

3.4 Immunomodulation

It balances hyperactive immune responses, making it beneficial for autoimmune diseases like lupus and allergies .

3.5 Metabolic Benefits

Hypoglycemic Action: Enhances insulin sensitivity and GLUT4 translocation, aiding diabetes management .
Cardioprotection: Relaxes vascular smooth muscle, improving blood flow and reducing hypertension .

3.6 Antiviral Activity

Luteolin inhibits HSV-2 replication by blocking viral entry and protease activity, outperforming acyclovir in some studies .

4. Applications

4.1 Pharmaceuticals

Cancer Adjuvant Therapy: Used in formulations targeting prostate, breast, and lung cancers .
Anti-Inflammatory Drugs: Incorporated into tablets or injectables for chronic inflammation .

4.2 Nutraceuticals

Dietary Supplements: Capsules or powders for antioxidant support and immune enhancement .
Functional Foods: Added to beverages or snacks for metabolic health .

4.3 Cosmetics

Anti-Aging Creams: Reduces UV-induced skin damage via antioxidant mechanisms .
Acne Treatments: Combats microbial growth and inflammation .

5. Quality Control

5.1 HPLC Analysis

Method: Reverse-phase C18 column, mobile phase (methanol/water/phosphoric acid), flow rate 0.5–1.5 mL/min .
Detection: UV absorbance at 270–348 nm .
Retention Time: ~4.9–16.85 minutes, depending on solvent system .

5.2 Batch Consistency

Certificates of Analysis (CoA): Provided for each batch, detailing purity, ash content, and residual solvents .
Stability Testing: Confirms shelf-life under recommended storage conditions .

6. Safety and Compliance

Toxicity Profile: LD₅₀ >2000 mg/kg in rodents, indicating low acute toxicity .
Regulatory Status: Complies with USP, EP, and FDA guidelines for dietary ingredients .

7. Why Choose Our Luteolin 98%?

Natural Sourcing: Extracted from non-GMO peanut shells or Arachis hypogaea .
Custom Specifications: Available in 85%, 90%, or 95% external purity to meet diverse needs .
Technical Support: Dedicated team assists with formulation and regulatory compliance .