10-Deacetylbaccatin III (10-DAB)

Whakaahuatanga Poto:

Ko te 10-Deacetylbaccatin III (C29H36O10) he diterpenoid koiora i tangohia mai i nga ngira me te kiri o teTaakemomo (rakau yew). Hei tohu matua mo te whakahiatotanga o te paclitaxel, te docetaxel, me etahi atu apiha chemotherapeutic e pa ana ki te taake, ka whakamahia nuitia te 10-DAB i roto i nga mahi R&D me te hanga tarukino oncology.

Ko te 10-Deacetylbaccatin III, e mohiotia ana ko 10-DAB, 10-DAB III ranei, he puhui pararopi taiao e hono tata ana mai i nga ngira maroke me nga manga iti o te rakau yew Pakeha (Taxus baccata). pacitaxel (taxol); cabazitaxel. I kitea te 10-10-deacetylbaccatin III ki te aukati i te tipu o te L. DONOVANI intracellular amastigotes i roto i te J774 murine macrophages in vitro i te nanomolar concentrations me te IC(50) uara o 70 nM.

Utu FOB:US 5 - 2000 / KG

Min.Ota Rahi:1 KG

Whakarato Kaha:10000 KG/ia Marama

Tauranga:Shanghai/Beijing

Nga tikanga utu:L/C,D/A,D/P,T/T,O/A

Nga tikanga tuku:Ma te moana/Ma te Rere/Ma te Karere

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Taipitopito Hua

Tohu Hua

Ingoa matū:	10-Deacetylbaccatin III
Tau CAS:	32981-86-5
kupu taurite:	10-Desacetylbaccatin III; 10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP poke);10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca [3,4] benz [1,2-b] oxet-5-one 12b-acetate, 12-benzoate (USP-benzoate);
Puka rāpoi:	C29H36O10
Te ahua:	Mā Mārō
Mol. Taumaha:	544.6
Rokiroki:	2-8°C Pouakao

Taitararoto: Takawaenga API i ahu mai i te tipu, CAS32981-86-5| GMP Tiwhikete, COA Ka whakaratohia

He aha te 10-Deacetylbaccatin III (10-DAB)?

Nga Whakatakotoranga Matua me nga waahanga

Pure: ≥98% (HPLC-UV whakamana, COA wātea)
Te ahua: Ma ki te paura tioata ma-kore
Wairewa: Wairewa ki te mewaro, waiwaro, DMSO; paku wairewa ki te wai
Rokiroki: Ka mau ki te -20°C i roto i nga ipu hau, maru i te marama
Te Putake Whakatipu: He mea hauhake tonuTaxus wallichiana(Himalayan yew)

Nga tono a 10-DAB

Te Whakakotahitanga Taaka Whakamate pukupuku
- Te takawaenga nui mo te hanga ahua-hangaia o te paclitaxel (Taxol®) me te docetaxel (Taxotere®).
- Ka whakamahia i roto i te R&D mo nga pärönaki taake hou e aro ana ki nga mate pukupuku aatete-whakarakau.
Rangahau matū koiora
- Te rangahau mo nga tikanga polymerization tubulin me te whakaurunga apoptosis.
- Paerewa tohutoro mo te matū tātari me te whakahaere kounga.
Tangohanga Hua Maori
- Ko te tukanga tangohanga hua nui e ū ana ki nga tikanga matū matū matomato.

He aha te Puna 10-DAB mai i a maatau?

✅ Kounga whaimana:

Tiwhikete Tiwhikete Tiwhikete (COA) motuhake me nga raraunga HPLC, MS, NMR.
He pai ki nga aratohu USP, EP, me ICH Q7 GMP.

✅ Pūtake Tauwhiro:

Ko te hauhake matatika mai i nga maara Taxus ngaki (e rite ana ki te CITES Appendix II).

✅ Rorohiko o te ao:

Ko te tuku mekameka makariri ki nga rohe o USA, EU me APAC.
Whakapaipai ka taea te whakarite (1g ki te 1kg, ipu karaihe amipere me te whakamaroke).

Tautoko Hangarau & Tuhituhi

MSDS kore utu (Raraunga Raraunga Haumaru Rawa) me nga raraunga pumau ina tono.
Ko te whakahiato ritenga me te utu nui e waatea ana mo nga hoa OEM.
Tautoko ture whakatapua mo nga tukunga IND/NDA.

Haumaru me te Tautukunga

Tau CAS: 32981-86-5
Waehere morearea: Ka mau ki te PPE (nga karapu, motiuri) - kaore he morearea mo te whakamahi ngaio.
Tūnga Ture: REACH rehita; Kei te waatea te DMF mo nga kaihoko rongoa.

FAQs mo 10-DAB

Q: Ka taea te whakamahi tika i te 10-DAB i roto i nga rangahau ahurea pūtau?
A: Kao. Me whakarereke matū (hei tauira, te taapiri-taha-taha) kia noho hei taake koiora.

Q: He aha te wa arahi mo nga ota 500g?
A: Waa whakaputa paerewa: 2-3 wiki. Kei te waatea te tuku tere.

P: Ka whakaratohia e koe nga kawa whakahiato taake?
A: Ae! Ko nga pepa maamaa hangarau e waatea ana mo nga kaihoko whai tohu.

Whakaahuatanga:
Puna 98% HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) - tangohanga Taxus kua whakamanahia e te GMP mo te whakahiato paclitaxel. Ko nga ota nui, COA/MSDS, me te tautoko ture.

Kupumatua:
- Tuatahi: "Kaiwhakarato 10-Deacetylbaccatin III", "Te parakore 10-DAB", "Paclitaxel precursor"
- Te hiku roa: "CAS 32981-86-5 utu", "Taxus tangohanga mo te rangahau mate pukupuku", "GMP 10-DAB"
Kupumatua:
- “Taxane intermediate”, “paclitaxel semi-synthetic”, “C29H36O10″, “te rakau yew”