Waikawa Azelaic 98%na HPLC | Koeke Rongoa me te Paku
1. Tirohanga Hua
Waikawa Azelaic(CAS123-99-9) he waikawa dicarboxylic kukū me te tauira rāpoi C₉H₁₆O₄ me te taumaha rāpoi 188.22 g/mol. Ko ta maatau HPLC-manatoko 98% te karaehe parakore e tutuki ana ki nga paerewa USP/EP, kua arotauhia mo nga hanganga kiri me nga tono ahumahi.
Whakatakotoranga Matua
- Maamaa: ≥98% (HPLC-ELSD kua whakamanahia, nga poke katoa <0.2%)
- Te ahua: Te paura tioata ma
- Ira Whakarewa: 109-111°C
- Ira Kohua: 286°C i te 100 mmHg
- Wairewa: 2.14 g/L i roto i te wai (25°C), wairewa i roto i nga wairewa waiwaro/waiwai
2. Te tohu matū
2.1 Manatokotanga Hanganga
- Kōtaha NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H ia, 4.10), 4.20 (t, 2H ia), 4.10 COOH) - HPLC Chromatogram:
Te Waa Pupuri: 20.5 min (te tihi matua), nga tihi poke <0.1% i te 31.5 / 41.5 min
2.2 Kawa Mana Kounga
| Tawhā | Tikanga | Paearu Whakaaetanga |
|---|---|---|
| Te whakamatautau | HPLC-ELSD (Agilent 1200) Tīwae: Purospher Star RP-C18 Wāhanga Pūkoro: Methanol/Water/Acetic Acid rōnaki | 98.0-102.0% |
| Nga Korewa Taamaha | ICP-MS | ≤10 ppm |
| Wairewa toenga | GC-FID (HP-5MS tīwae) Te whakaputa me te HMDS | Ewaro <0.5% |
3. Nga tono rongoa
3.1 Te Whainga Whaiaro
- Acne vulgaris:
Ka whakaheke i te comedones e 65% i roto i nga whakamatautau 12-wiki (20% kirīmi) mā:- Nga mahi antimicrobial kiC. hakihaki(MIC₅₀ 256 μg/mL)
- Ko te aukati Tyrosinase (IC₅₀ 3.8 mM) mo te hyperpigmentation post-inflammatory
- Rosacea:
Ko te 15% gel e whakaatu ana i te 72% te whakaheke i te erythema (me te 43% placebo) na roto i:- Te ROS scavenging (EC₅₀ 8.3 μM)
- Ko te whakakore MMP-9 i roto i nga keratinocytes
3.2 Nga Aratohu Hanga
| Puka Inenga | Manakohia % | Tuhipoka Hototahi |
|---|---|---|
| Kirīmi/Geera | 15-20% | A ape i te methylparaben (e 42% te paheketanga) |
| Liposomal | 5-10% | Whakamahia te phosphate buffer pH7.4 + soybean lecithin |
4. Nga tono whakapaipai
4.1 Whakamaamaa Synergy
- Pahekotanga Tino Pai:
- 2% AzA + 5% Huaora C: 31% te whakaiti melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x te whakanui whakahiato collagen
4.2 Raraunga Pumau
| Tikanga | Rere Paheketanga |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Te Whakaaturanga UV | 1.2% (me te tiaki TiO₂) |
5. Whakamahinga Ahumahi
- Waiwaiwai Waitohu:
- Nylon-6,9 te whakahiato (te tuku tauhohenga> 85% i te 220°C)
- Te aukati waikura mo nga koranu rino (ko te otinga 0.1M ka whakaheke te waikura ma te 92%)
6. Haumaru me te Ture
6.1 Tuhinga Toxicological
| Tawhā | Hua |
|---|---|
| Acute waha LD₅₀ (Kiore) | >5000 mg/kg |
| Te kiri kiri | He ngawari (OECD 404) |
| Morearea Mata | Kāwai 2B |
6.2 Tautukunga Ao
- Tiwhikete:
- US FDA Drug Kaiwhakaako Kōnae
- EU REACH Kua Rehitatia
- ISO 9001:2015 Pūnaha Kounga
7. Packaging & Rokiroki
| Te nui | Ipu | Utu (EXW) |
|---|---|---|
| 25 kg | Pahū HDPE + putea Alu | $4,800 |
| 1 kg | Te pounamu karaihe amipere | $220 |
| 100 g | Pukoro hiri-rua | $65 |
Rokiroki: 2-8°C i roto i te taiao maroke (te mahana ruma ka whakaaetia mena <25°C/60% RH)
8. FAQ
Q: Ka taea e au te whakamahi i te waikawa azelaic me te niacinamide?
A: Ae, ko nga raraunga haumanu e whakaatu ana 10% AzA + 4% niacinamide te whakapai ake i te manawanui 37% vs AzA anake
P: He aha te oranga o te papa?
A: 36 marama ka penapena tika. Ko te COA motuhake kua whakaratohia
9. Tohutoro
- Ko nga korero mo te NMR
- Tikanga HPLC-ELSD
- Matauranga pumau
- Te kaha haumanu
