Product Name:N-Acetyl-L-Cysteine Ethyl Ester
Other Name:Ethyl (2R)-2-acetamido-3-sulfanylpropanoate;
Ethyl N-acetyl-L-cysteinate
CAS No:59587-09-6
Specifications: 99.0%
Colour: white to off-white solid with characteristic odor and taste
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Product Description: N-Acetyl-L-Cysteine Ethyl Ester (NACET)
—A Potent Antioxidant and Glutathione Precursor with Enhanced Bioavailability—
Key Features & Benefits
- Superior Bioavailability: NACET exhibits 70-80%+ oral bioavailability, far exceeding traditional NAC (6%) due to its lipophilic, charge-free structure, enabling efficient cellular penetration and blood-brain barrier crossing .
- Powerful Antioxidant Activity: Acts as a direct scavenger of free radicals and a precursor to glutathione (GSH), the body’s master antioxidant, supporting detoxification, immune function, and tissue repair .
- Multi-Organ Protection:
- Liver/Kidney: At 50 mg/kg twice daily, NACET increases GSH levels in the liver, kidney, heart, and brain, mitigating oxidative damage from toxins like valproate .
- Retina: Protects retinal pigment epithelial (RPE) cells against H₂O₂-induced oxidative stress, outperforming NAC in enhancing intracellular GSH reserves .
- Anti-Inflammatory & Antimicrobial Applications:
- Reduces catheter-associated infections via S-nitroso-NACET (SNACET), a nitric oxide (NO)-releasing lock solution that inhibits >99% of S. aureus and E. coli adhesion .
- Exhibits anti-inflammatory and anticancer properties by suppressing DNA replication and inducing apoptosis .
Chemical Properties
- Molecular Formula: C₇H₁₃NO₃S
- Molecular Weight: 191.25 g/mol
- CAS Number: 59587-09-6
- Storage: Store at 2–8°C in a dry environment .
Pharmacological Advantages Over NAC
- Enhanced Absorption: Ethyl esterification eliminates NAC’s negative charge at physiological pH, improving lipophilicity and systemic distribution .
- Targeted Delivery: Avoids rapid uptake in the gut/liver, ensuring cysteine reaches critical organs, including the brain .
- Synergistic Formulations: Often combined with selenium, molybdenum, and glycine to boost glutathione synthesis and cellular transport .
Quality Assurance & Detection Methods
- Analytical Precision: Quantified via sequential injection analysis (SIA) using Cu(II)-ligand complexes (e.g., bathocuproine disulfonic acid), achieving detection limits as low as 2.6 × 10⁻⁶ mol/L .
- Pharmaceutical Compliance: Free from interference by common excipients, ensuring reliability in drug formulations .
Recommended Usage
- Dosage: 50–100 mg/day (equivalent to 660+ mg of NAC). May be taken up to 3x daily .
- Safety: No reported side effects in toxicity studies; consult a physician if on blood thinners .
Applications
- Dietary Supplements: Supports antioxidant defense, cognitive health, and detoxification.
- Pharmaceuticals: Potential mucolytic agent, paracetamol antidote, and adjuvant in AMD/diabetic retinopathy therapy .
- Medical Devices: SNACET-based catheter locks for preventing bloodstream infections .
FAQ
- Odor: Sulfur-like smell due to cysteine’s thiol group, essential for free radical scavenging .
- Drug Interactions: May slow blood clotting; monitor with anticoagulants .
Order Now
- Purity: ≥95% (HPLC)
- Packaging: 100 mg/vial
- Delivery: Ships within 5 business days
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