Nefiracetam: A Multifunctional Nootropic Agent for Cognitive Enhancement and Neuroprotection
(Optimized for Laboratory Research Use)
Product Overview
Nefiracetam (CAS 77191-36-7) is a synthetic pyrrolidone derivative and a potent nootropic agent with multimodal neuroenhancing properties. Developed initially for Alzheimer’s disease, it is now widely studied for cognitive enhancement, neuroprotection, and anticonvulsant applications .
Key Features:
- Cognitive Enhancement: Improves memory, focus, and learning capacity through GABAergic, cholinergic, and monoaminergic pathways .
- Neuroprotective Effects: Reduces neuronal damage in ischemic conditions and inhibits beta-amyloid-induced inflammation .
- Anticonvulsant Activity: Suppresses Ro 5-4864-induced seizures and amygdala-kindled seizures in preclinical models .
- Phase 2 Clinical Trials: Under investigation for cerebrovascular disorders and post-stroke depression .
Chemical & Pharmacological Profile
- Molecular Formula: C₁₄H₁₈N₂O₂ | Molecular Weight: 246.3 g/mol .
- Solubility:
- DMSO: 24.6 mg/mL (100 mM)
- Ethanol: 24.6 mg/mL (100 mM)
- Water: 5 mg/mL (limited solubility) .
- Mechanism of Action:
- Enhances L/N-type calcium channel activity and nicotinic acetylcholine receptor (nAChR) function .
- Modulates PKC and PKA pathways to promote hippocampal synaptic plasticity .
- Increases GABAergic transmission and glutamate release for neuroprotection .
Applications in Research
- Cognitive Studies:
- Improves passive avoidance retention and reverses scopolamine-induced amnesia in rodents .
- Enhances language learning via speech center modulation .
- Neurological Disorders:
- Reduces apathy and psychiatric symptoms in stroke patients .
- Potential therapy for Alzheimer’s, Parkinson’s, and age-related cognitive decline .
- Anticonvulsant Research:
- Inhibits seizure propagation in amygdala-kindled models (IC₅₀ data available upon request) .
Safety & Handling
- GHS Classification: Acute Oral Toxicity Category 4 (H302). Not classified as hazardous for transport .
- Handling Precautions:Disposal: Comply with local regulations for chemical waste (EPA/DOT guidelines) .
- Avoid inhalation, skin/eye contact. Use PPE (gloves, N95 mask) in well-ventilated areas .
- Store at -20°C (powder, 3-year stability) or -80°C (solution, 2-year stability) .
Why Choose Our Nefiracetam?
- High Purity: >98% verified by HPLC .
- Global Compliance: Meets USP, FDA, and EMA standards for research use .
- Bulk Availability: 25 mg to 1 g packaging with expedited shipping .
Keywords
Nootropic agent, Cognitive enhancer, GABAergic modulator, Neuroprotective compound, Anticonvulsant drug, Phase 2 clinical trials, Alzheimer’s research, Synaptic plasticity, Ro 5-4864 antagonist.
