Product Name:Nicotinamide riboside chloride powder
Other Name:3-(Aminocarbonyl)-1-P-D-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride; NR, vitamin NR;
CAS No:23111-00-4
Assay: 98% min
Colour: Off White to Pale Yellow Powder
GMO Status:GMO Free
Packing: in 25kgs fiber drums
Storage:Keep container unopened in cool, dry place,Keep away from strong light
Shelf Life:24 months from date of production
Nicotinamide Riboside Chloride Powder: Premium NAD+ Precursor for Enhanced Health and Longevity
Product Overview
Nicotinamide Riboside Chloride (NR-Cl) is a crystalline form of Vitamin B3, recognized as a highly efficient precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for cellular energy metabolism, DNA repair, and healthy aging . With the chemical formula C11H15N2O5Cl and molecular weight 290.70 g/mol, it is synthesized to ≥95% purity (HPLC) and complies with FDA GRAS (Generally Recognized as Safe) standards .
Key Benefits
- Boosts NAD+ Levels:
NR-Cl increases intracellular NAD+ by ~220%, outperforming nicotinamide (NAM) and nicotinic acid (NA) without causing flushing or inhibiting sirtuins . Enhanced NAD+ supports mitochondrial function, energy production, and activation of longevity-associated proteins like SIRT1 and SIRT3 . - Anti-Aging & Neuroprotection:
Clinical studies demonstrate NR-Cl’s role in reducing cognitive decline in Alzheimer’s models and promoting healthy aging by maintaining NAD+-dependent cellular repair mechanisms . - Metabolic Health:
Prevents high-fat diet-induced metabolic abnormalities and supports weight management by enhancing oxidative metabolism . - Safety & Efficacy:
- FDA-Approved: Three GRAS notifications and four published human clinical trials confirm safety at doses up to 2,000 mg/day (recommended: 250–300 mg/day) .
- No Side Effects: Unlike NMN (Nicotinamide Mononucleotide), NR-Cl is orally bioavailable, stable in capsules, and avoids injection-related risks .
Product Advantages
- Crystalline Purity: Recrystallized in polar solvents (e.g., methanol), NR-Cl offers superior stability and chemical purity compared to amorphous forms .
- Global Compliance: Approved under EU Novel Food Regulations (EU 2017/2470) with CAS No. 23111-00-4, ensuring regulatory adherence for supplements and research .
- Versatile Applications: Suitable for tablets, capsules, and liquid formulations. Compatible with DMSO (172 mM) and water (430 mM) for laboratory use .
NR-Cl vs. NMN: Why Choose NR-Cl?
| Feature | NR-Cl | NMN |
|---|---|---|
| Bioavailability | Direct cellular uptake | Requires conversion to NR |
| Human Clinical Trials | 4+ published studies | Limited data |
| Safety Profile | FDA GRAS, no adverse effects | No long-term safety data |
| Formulation Ease | Stable in capsules (300 mg) | Challenging to encapsulate |
| Cost-Effectiveness | Higher NAD+ yield per dose | Lower efficiency |
Usage & Storage
- Recommended Dosage: 250–300 mg/day for supplements; adjust based on research needs .
- Storage: Store at -20°C (powder, 3 years) or -80°C (solution, 1 year). Protect from light and moisture .
- Solubility:
- H2O: 125 mg/mL (sonication recommended).
- DMSO: 50 mg/mL .
Why Choose Us?
- Bulk Supply: 3,000 kg ready stock with bulk discounts and free COA (Certificate of Analysis) .
- Quality Assurance: Rigorous testing for NR assay, heavy metals, and NMR identification .
- Global Delivery: Fast shipping and dedicated support for research and commercial partnerships .
Contact Us Today for samples, pricing, and custom formulations tailored to your needs!
Keywords: NAD+ precursor, Vitamin B3, anti-aging supplement, NR chloride bulk powder, FDA GRAS, crystalline nicotinamide riboside, NAD+ booster
