Mu 1913, wasayansi waku Sweden, Pulofesa Kylin adapeza chinthu chomata cha kelp, fucoidan, ku Yunivesite ya Uppsala.Amatchedwanso "fucoidan", "fucoidan sulfate", "fucoidan", "fucoidan sulfate", etc., dzina la Chingerezi ndi "Fucoidan".Ndi polysaccharide yosungunuka m'madzi yopangidwa ndi fucose yomwe ili ndi magulu a sulphate.Zimapezeka makamaka pamatope a algae a bulauni (monga udzu wa m'nyanja, wakame spores, ndi kelp).Zomwe zili ndi pafupifupi 0.1%, ndipo zomwe zili mu kelp youma ndi pafupifupi 1%.Ndi chinthu chamtengo wapatali chogwira ntchito m'madzi am'nyanja.
Choyamba, mphamvu ya fucoidan
Panopa Japan ndi dziko limene lili ndi moyo wautali kwambiri padziko lonse.Panthawi imodzimodziyo, dziko la Japan lili ndi chiwerengero chotsika kwambiri cha matenda aakulu.Malinga ndi akatswiri a kadyedwe, chimodzi mwa zifukwa zofunika kwambiri za thanzi la anthu a ku Japan chingakhale chokhudzana ndi kudya zakudya zam'nyanja nthawi zonse.Fucoidan yomwe ili mu algae wa bulauni monga kelp ndi chinthu chogwira ntchito ndi machitidwe osiyanasiyana a thupi.Ngakhale kuti adapezedwa ndi Pulofesa Kylin mu 1913, mpaka 1996 Fucoidan idasindikizidwa pa 55th Japanese Cancer Society Conference.Lipoti loti "limatha kuyambitsa khansa ya apoptosis" ladzutsa nkhawa anthu ambiri ophunzira ndipo lachititsa kuti kafukufuku achuluke.
Pakalipano, gulu lachipatala likuchita kafukufuku pa ntchito zosiyanasiyana zamoyo za fucoidan, ndipo lasindikiza mapepala zikwizikwi m'mabuku azachipatala apadziko lonse, kutsimikizira kuti fucoidan ili ndi ntchito zosiyanasiyana zamoyo, monga anti-chotupa, kukonza m'mimba, ndi antioxidant , Kupititsa patsogolo chitetezo chokwanira. , antithrombotic, kutsika kwa magazi, antiviral zotsatira.
(I) Fucoidan imathandizira bwino m'mimba
Helicobacter pylori ndi helical, microaerobic, gram-negative bacilli yomwe imakhala yovuta kwambiri pakukula.Ndi mtundu wokhawo wa tizilombo tomwe timadziwika kuti timakhala m'mimba mwa munthu.Matenda a Helicobacter pylori amayambitsa gastritis ndi zilonda zam'mimba.Zilonda, lymphoproliferative gastric lymphomas, ndi zina zotero, zimakhala ndi matenda a khansa ya m'mimba.
Njira zowonongeka za H. pylori zikuphatikizapo: (1) kumamatira: H. pylori akhoza kudutsa ngati ntchofu wosanjikiza ndi kumamatira ku maselo am'mimba a epithelial;(2) kuchepetsa asidi wa m'mimba kuti apulumuke: H. pylori imatulutsa urease, ndipo Urea m'mimba imachita kupanga mpweya wa ammonia, womwe umapangitsa kuti asidi am'mimba asawonongeke;(3) amawononga chapamimba mucosa: Helicobacter pylori amatulutsa VacA poizoni ndi amawononga pamwamba maselo a chapamimba mucosa;(4) umapanga poizoni chloramine: ammonia mpweya mwachindunji kukokolola chapamimba mucosa, ndi zotakasika mpweya Zimene umabala kwambiri poizoni chloramine;(5) Zimayambitsa kuyankha kotupa: Pofuna kuteteza ku Helicobacter pylori, maselo ambiri oyera amagazi amasonkhana pamimba ya m'mimba kuti apange yankho lotupa.
Zotsatira za fucoidan motsutsana ndi Helicobacter pylori zikuphatikizapo:
1. Kuletsa kuchuluka kwa Helicobacter pylori;
Mu 2014, gulu lofufuza la Yun-Bae Kim ku Chungbuk National University ku South Korea linasindikiza kafukufuku wosonyeza kuti fucoidan ili ndi zotsatira zabwino kwambiri za antibacterial, ndipo fucoidan pa ndende ya 100µg / mL ikhoza kulepheretsa kufalikira kwa H. pylori.(Lab Anim Res2014: 30 (1), 28-34.)
2. Pewani kumamatira ndi kuwukira kwa Helicobacter pylori;
Fucoidan ili ndi magulu a sulphate ndipo imatha kumangirira ku Helicobacter pylori kuti isamamatire ku maselo am'mimba a epithelial.Nthawi yomweyo, Fucoidan imatha kuletsa kupanga urease ndikuteteza chilengedwe cha acidic cha m'mimba.
3. Antioxidant kwenikweni, kuchepetsa kupanga poizoni;
Fucoidan ndi antioxidant wabwino, yemwe amatha kuwononga mwachangu ma radicals opanda okosijeni ndikuchepetsa kupanga kwa poizoni wa chloramine.
4. Anti-inflammatory effect.
Fucoidan imatha kuletsa ntchito ya lectin yosankha, yothandiza ndi heparanase, ndikuchepetsa kuyankha kotupa.(Helicobacter, 2015, 20, 89-97.)
Kuonjezera apo, ofufuzawo adapeza kuti fucoidan imakhudza kwambiri thanzi la m'mimba ndipo imakhala ndi njira ziwiri zowonongeka m'matumbo: kukonza kudzimbidwa ndi enteritis.
Mu 2017, gulu lofufuza kuchokera kwa Pulofesa Ryuji Takeda wa Kansai University of Welfare Sciences ku Japan adachita kafukufuku.Anasankha odwala 30 omwe ali ndi vuto la kudzimbidwa ndipo anawagawa m'magulu awiri.Gulu loyesera linapatsidwa 1 g ya fucoidan ndipo gulu lolamulira linapatsidwa placebo.Miyezi iwiri pambuyo mayeso, anapeza kuti chiwerengero cha masiku defecation pa sabata mu mayeso gulu kutenga fucoidan kuchuluka kwa pafupifupi 2.7 masiku 4.6 masiku, ndi defecation voliyumu ndi softness chinawonjezeka kwambiri.(Zakudya Zogwira Ntchito mu Zaumoyo ndi Matenda 2017, 7: 735-742.)
Mu 2015, gulu la Pulofesa Nuri Gueven wa yunivesite ya Tasmania, Australia, adapeza kuti fucoidan ikhoza kusintha bwino matenda a enteritis mu mbewa, kumbali imodzi, ingathandize mbewa kubwezeretsa kulemera kwake ndikuwonjezera kuuma kwa defecation;kumbali ina, imatha kuchepetsa kulemera kwa colon ndi ndulu.Amachepetsa kutupa m'thupi.(PLoS ONE 2015, 10: e0128453.)
B) Antitumor zotsatira za fucoidan
Kafukufuku wokhudza antitumor effect wa fucoidan pakadali pano ndiwokhudzidwa kwambiri ndi maphunziro, ndipo zotsatira zambiri zapezeka.
1. Kuwongolera kayendedwe ka maselo otupa
Mu 2015, Pulofesa Lee Sang Hun ndi ena ku Soonchunhyang University ku South Korea ndi ofufuza ena anapeza kuti fucoidan liletsa mawu a cyclin Cyclin ndi cyclin kinase CDK mu chotupa maselo ndi kulamulira kukula mkombero wa maselo a khansa ya m'matumbo a munthu, zimakhudza mitosis yachibadwa ya chotupa maselo.Ma cell chotupa omwe ali mu pre-mitotic phase ndikuletsa kuchuluka kwa maselo otupa.(Malipoti a Molecular Medicine, 2015, 12, 3446.)
2.Kulowetsedwa kwa chotupa cell apoptosis
Mu 2012, kafukufuku wofalitsidwa ndi gulu lofufuza la Quan Li ku yunivesite ya Qingdao adapeza kuti fucoidan imatha kuyambitsa chizindikiro cha apoptosis cha maselo otupa-Bax apoptosis mapuloteni, kuchititsa kuwonongeka kwa DNA ku maselo a khansa ya m'mawere, kuphatikizika kwa chromosome, ndikupangitsa kuti apoptosis adziwike., Kuletsa kukula kwa chotupa maselo mu mbewa.(Plos One, 2012, 7, e43483.)
3.Kuletsa chotupa cell metastasis
Mu 2015, Chang-Jer Wu ndi ofufuza ena ochokera ku National Taiwan Ocean University adasindikiza kafukufuku wosonyeza kuti fucoidan ikhoza kuonjezera kufotokozera kwa minofu yoletsa chinthu (TIMP) ndi kutsika-regulate matrix metalloproteinase (MMP) kufotokoza, potero kulepheretsa chotupa cell metastasis.(Mar. Mankhwala osokoneza bongo 2015, 13, 1882.)
4.Kuletsa chotupa angiogenesis
Mu 2015, gulu lofufuza la Tz-Chong Chou ku Taiwan Medical Center lidapeza kuti fucoidan imatha kuchepetsa kupangika kwa vascular endothelial growth factor (VEGF), kuletsa neovascularization ya zotupa, kudula zakudya zopatsa thanzi, kufa ndi njala zotupa. kwambiri Kuletsa kufalikira ndi metastasis maselo chotupa.(Mar. Mankhwala 2015, 13, 4436.)
5.Yambitsani chitetezo cha mthupi
Mu 2006, Pulofesa Takahisa Nakano waku Kitasatouniversity University ku Japan adapeza kuti fucoidan imatha kulimbitsa chitetezo chathupi komanso kugwiritsa ntchito chitetezo chamthupi cha wodwalayo kupha makamaka ma cell a khansa.Fucoidan ikalowa m'matumbo, imatha kuzindikirika ndi maselo a chitetezo chamthupi, kupanga zizindikiro zomwe zimathandizira chitetezo chamthupi, ndikuyambitsa ma cell a NK, B cell, ndi T cell, potero kupanga ma antibodies omwe amamanga ma cell a khansa ndi ma T cell omwe amapha khansa. maselo.Kupha mwachindunji kwa maselo a khansa, kulepheretsa kukula kwa maselo a khansa.(Planta Medica, 2006, 72, 1415.)
Kupanga kwa Fucoidan
Zomwe zili m'magulu a sulphate m'maselo a fucoidan ndi chizindikiro chofunikira chomwe chimatsimikizira zochitika zake za thupi, komanso ndizofunikira kwambiri paubwenzi wa fucoidan.Chifukwa chake, zomwe zili mu gulu la sulphate ndizofunikira pakuwunika mtundu wa fucoidan komanso ubale wantchito.
Posachedwa, chilolezo chopanga chakudya cha fucoidan polysaccharide chidatsimikiziridwa ndi Food and Drug Administration ndikuperekedwa kwa Qingdao Mingyue Seaweed Group, zomwe zikutanthauza kuti Mingyue Seaweed Group yakhala ikulima kwambiri nyanja kwazaka zopitilira 50.Pezani ziphaso zovomerezeka.Akuti Mingyue Seaweed Gulu lapanga mzere wopanga fucoidan wokhala ndi matani 10 pachaka.M'tsogolomu, idzapereka masewera onse ku "mankhwala ndi chakudya cham'madzi" komanso kuwala muzakudya zogwira ntchito zamakampani akuluakulu azaumoyo.
Gulu la Mingyue Seaweed, monga bizinesi yovomerezeka kuti ipange chakudya cha fucoidan, ili ndi zaka zambiri zopanga.Fucoidan yomwe imapangidwa ndi iyo ndi chida chokwezera ukadaulo choyambirira cha kelp concentrate / ufa.Kugwiritsa ntchito algae wa bulauni wapamwamba kwambiri ngati zopangira, kuyeretsedwa kwina ndi kulekanitsidwa kutengera ukadaulo wochotsa zachilengedwe, sikuti kumangowonjezera kukoma ndi kukoma kwa chinthucho, komanso kumawonjezera zomwe zili mu fucoidan polysaccharide (kuyera), zomwe zingagwiritsidwe ntchito minda yambiri monga zakudya zinchito ndi thanzi zakudya..Iwo ali ubwino mkulu mankhwala chiyero ndi mkulu zili magulu zinchito;kuchotsa zitsulo zolemera, chitetezo chachikulu;desalination ndi nsomba, kukoma ndi kununkhira bwino.
Kugwiritsa ntchito Fucoidan
Pakalipano, pali zinthu zambiri za fucoidan zomwe zapangidwa ndikugwiritsidwa ntchito ku Japan, South Korea, United States ndi maiko ena, monga fucoidan yowonjezera yowonjezera, makapisozi a fucoidan yaiwisi, ndi mafuta odzola amchere apamwamba a fucoidan.Zakudya zogwira ntchito monga Qingyou Le Gulu la Seaweed, Rockweed Treasure, Chakumwa cha Brown Algae Plant
M’zaka zaposachedwapa, “Lipoti la Mkhalidwe wa Chakudya cha Anthu a ku China ndi Matenda Osatha” limasonyeza kuti kadyedwe ka anthu okhala ku China asintha, ndipo kufalikira kwa matenda aakulu kukuwonjezereka.Ntchito zazikulu zaumoyo zokhudzana ndi "kuchiza matenda" zakopa chidwi kwambiri.Kugwiritsa ntchito fucoidan kupanga ndi kupanga zakudya zambiri zogwira ntchito kudzafufuza bwino phindu la fucoidan kuti apereke moyo ndi thanzi, zomwe ziri zofunika kwambiri pa chitukuko cha "mankhwala athanzi ndi homology ya chakudya" makampani akuluakulu azaumoyo.
Ulalo wazinthu: https://www.trbextract.com/1926.html
Nthawi yotumiza: Mar-24-2020