Kachilombo ka Covid-19, kapenanso kachirombo ka 2019-nCoV kapena SARS-CoV-2, ndi m'banja la Coronavirus.Popeza SARS-CoV-2 ndi ya β genus Coronavirus imagwirizana kwambiri ndi MERS-CoV ndi SARS-CoV - zomwe zanenedwanso kuti zimayambitsa zizindikiro zazikulu za chibayo m'miliri yam'mbuyomu.Mapangidwe a majini a 2019-nCoV adadziwika ndikusindikizidwa.[i] [ii] Mapuloteni akuluakulu omwe ali mu kachilomboka komanso omwe adadziwika kale ku SARS-CoV kapena MERS-CoV amawonetsa kufanana kwakukulu pakati pawo.
Zachilendo za mtundu wa kachilomboka kameneka zikutanthauza kuti pali kusatsimikizika kochuluka kozungulira kachitidwe kake, chifukwa chake ndi molawirira kwambiri kuti muwone ngati zitsamba kapena mankhwala azitsamba angathandize pagulu ngati prophylactic agents kapena ngati zinthu zoyenera mu anti-coronavirus mankhwala motsutsana ndi Covid. -19.Komabe, chifukwa cha kufanana kwakukulu kwa Covid-19 ndi ma virus omwe adanenedwa kale a SARS-CoV ndi MERS-CoV, kafukufuku wofalitsidwa kale pamankhwala azitsamba, omwe atsimikiziridwa kuti ali ndi zotsatira zotsutsana ndi coronavirus, atha kukhala chitsogozo chofunikira chopezera odana ndi coronavirus. zitsamba, zomwe zitha kukhala zogwira ntchito motsutsana ndi kachilombo ka SARS-CoV-2.
Pambuyo pa kuphulika kwa SARS-CoV, yomwe idanenedwa koyamba koyambirira kwa 2003[iii], asayansi akhala akuyesera mwamphamvu kugwiritsa ntchito mankhwala angapo oletsa ma virus motsutsana ndi SARS-CoV.Izi zidapangitsa gulu la akatswiri ku China kuti awonere mankhwala opitilira 200 aku China omwe amamwa mankhwala oletsa ma virus polimbana ndi vuto la coronavirus.
Mwa izi, zotulutsa zinayi zomwe zidawonetsa zoletsa zolimbana ndi SARS-CoV - Lycoris radiata (Red Spider Lily), Pyrrosia lingua (fern), Artemisia annua (Wokoma chowawa) ndi a Lindera aggregate (chitsamba chonunkhira chokhazikika cha banja la laurel. ).The sapha mavairasi oyambitsa zotsatira za izi anali mlingo amadalira ndi ranged kuchokera otsika ndende ya Tingafinye mkulu, mosiyanasiyana aliyense Tingafinye mankhwala.Makamaka Lycoris radiata adawonetsa ntchito yolimbana ndi ma virus kwambiri polimbana ndi kachilomboka.[iv]
Chotsatirachi chinali chogwirizana ndi cha magulu ena awiri ofufuza, omwe adanenanso kuti gawo logwira ntchito lomwe lili mu mizu ya Licorice, Glycyrrhizin, latsimikiziridwa kuti lili ndi zochita zotsutsana ndi SARS-CoV poletsa kubwereza kwake.[v] [vi] M'malo ena. Kafukufuku, Glycyrrhizin adawonetsanso ntchito yoletsa ma virus atayesedwa mu vitro antiviral zotsatira pazachipatala 10 zodzipatula za SARS coronavirus.Baicalin - gawo la chomera cha Scuttelaria baicalensis (Skullcap) - adayesedwanso mu kafukufukuyu pansi pamikhalidwe yomweyi ndipo awonetsanso zochita zolimbana ndi ma virus a SARS. -1 virus in vitro m'maphunziro am'mbuyomu.[viii] [ix] Komabe ziyenera kudziwidwa kuti zomwe zapezedwa mu vitro sizingafanane ndi mphamvu yachipatala mu vivo.Izi ndichifukwa choti mlingo wapakamwa wa mankhwalawa mwa anthu sungathe kukwaniritsa kuchuluka kwa seramu yamagazi yofanana ndi yomwe idayesedwa mu vitro.
Lycorine yawonetsanso mphamvu yoletsa ma virus ku SARS-CoV.3 Malipoti angapo am'mbuyomu akuwonetsa kuti Lycorine ikuwoneka kuti ili ndi ntchito zambiri zoletsa ma virus ndipo akuti yawonetsa zolepheretsa kachilombo ka Herpes Simplex (mtundu I)[x] ndi Poliomyelitis. HIV [xi]
"Zitsamba zina zomwe zanenedwa kuti zawonetsa antivayirasi motsutsana ndi SARS-CoV ndi Lonicera japonica (Honeysuckle waku Japan) ndi chomera chodziwika bwino cha Eucalyptus, ndi Panax ginseng (muzu) kudzera mu gawo lake logwira ntchito la Ginsenoside-Rb1."[xii]
Umboni wochokera m'maphunziro omwe tawatchulawa komanso kafukufuku wina wapadziko lonse lapansi akuti mankhwala azitsamba ambiri awonetsa ntchito zoletsa ma virus polimbana ndi ma virus [xiii] [xiv] ndipo njira yawo yayikulu ikuwoneka kuti ndikuletsa kubwereza kwa ma virus.[xv] China wagwiritsa ntchito kwambiri mankhwala azitsamba achi China pochiza SARS mogwira mtima nthawi zambiri.[xvi] Komabe palibe umboni wokwanira wotsimikizira kuti mankhwalawa ndi othandiza kwa odwala omwe ali ndi Covid-19.
Kodi zitsamba zotere zitha kukhala zomwe zingapangitse kuti pakhale mankhwala atsopano oletsa ma virus popewa kapena kuchiza SARS?
ZOYENERA KUDZIWA: Nkhaniyi idalembedwa kuti ingofuna kudziwa zambiri zokha ndipo sinapangidwe m'malo mwa upangiri wachipatala, matenda kapena chithandizo.Ngati mukuganiza kuti mutha kukhala ndi zisonyezo zokhudzana ndi za Covid-19 kapena matenda ena aliwonse, itanani dokotala nthawi yomweyo.
[I] Zhou, P., Yang, X., Wang, X. et al., 2020. Mliri wa chibayo wolumikizidwa ndi coronavirus yatsopano yomwe mwina idachokera.Chilengedwe 579, 270-273 (2020).https://doi.org/10.1038/s41586-020-2012-7
[Ii] Andersen, KG, Rambaut, A., Lipkin, WI, Holmes, EC ndi Garry, RF, 2020. Chiyambi chapafupi cha SARS-CoV-2.Nature Medicine, pp.1-3.
[iii] CDC SARS Response nthawi.Ipezeka pa https://www.cdc.gov/about/history/sars/timeline.htm.Kufikira
[iv] Li, SY, Chen, C., Zhang, HQ, Guo, HY, Wang, H., Wang, L., Zhang, X., Hua, SN, Yu, J., Xiao, PG ndi Li, RS, 2005. Kuzindikiritsa zinthu zachilengedwe zokhala ndi antivayirasi motsutsana ndi coronavirus yokhudzana ndi SARS.Kafukufuku wa antiviral, 67 (1), pp.18-23.
[v] Cinatl, J., Morgenstem, B. ndi Bauer, G., 2003. Glycyrrhizin, chigawo chogwira ntchito cha mizu ya licorice ndi kubwereza kwa coronovirus yogwirizana ndi SARS.Lancet, 361(9374), pp.2045-2046.
[vi] Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, GA, Doerr, HW ndi Cinatl, J., 2005. Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS-Coronavirus.Journal of chemistry yamankhwala, 48 (4), pp.1256-1259.
[vii] Chen, F., Chan, KH, Jiang, Y., Kao, RYT, Lu, HT, Fan, KW, Cheng, VCC, Tsui, WHW, Hung, IFN, Lee, TSW and Guan, Y., 2004. In vitro susceptibility of 10 clinic isolates of SARS coronavirus to osankhidwa antiviral mankhwala.Journal of Clinical Virology, 31 (1), pp.69-75.
[viii] Kitamura, K., Honda, M., Yoshizaki, H., Yamamoto, S., Nakane, H., Fukushima, M., Ono, K. and Tokunaga, T., 1998. Baicalin, an inhibitor of HIV-1 kupanga mu vitro.Kafukufuku wa antiviral, 37 (2), pp.131-140.
[ix] Li, BQ, Fu, T., Dongyan, Y., Mikovits, JA, Ruscetti, FW ndi Wang, JM, 2000. Flavonoid baicalin imalepheretsa kachilombo ka HIV-1 pamlingo wolowera mavairasi.Kuyankhulana kwa kafukufuku wa zamoyo ndi biophysical, 276 (2), pp.534-538.
[x] Renard-Nozaki, J., Kim, T., Imakura, Y., Kihara, M. ndi Kobayashi, S., 1989. Zotsatira za alkaloids olekanitsidwa ndi Amaryllidaceae pa kachilombo ka herpes simplex.Kafukufuku mu virology, 140, pp.115-128.
[xi] Ieven, M., Vlietinick, AJ, Berghe, DV, Totte, J., Dommisse, R., Esmans, E. ndi Alderweireldt, F., 1982. Plant antiviral agents.III.Kudzipatula kwa alkaloids kuchokera ku Clivia miniata Regel (Amaryl-lidaceae).Journal of Natural Products, 45 (5), pp.564-573.
[xii] Wu, CY, Jan, JT, Ma, SH, Kuo, CJ, Juan, HF, Cheng, YSE, Hsu, HH, Huang, HC, Wu, D., Brik, A. ndi Liang, FS, 2004 Tizilombo tating'ono tomwe timayang'ana kwambiri pachimake kupuma kwa coronavirus yamunthu.Zokambirana za National Academy of Sciences, 101 (27), pp.10012-10017.
[xiii] Wen, CC, Kuo, YH, Jan, JT, Liang, PH, Wang, SY, Liu, HG, Lee, CK, Chang, ST, Kuo, CJ, Lee, SS ndi Hou, CC, 2007. Specific plant terpenoids ndi lignoids ali ndi mphamvu zoletsa ma virus polimbana ndi chifuwa chachikulu cha kupuma kwa coronavirus.Journal of chemistry yamankhwala, 50 (17), pp.4087-4095.
[xiv] McCutcheon, AR, Roberts, TE, Gibbons, E., Ellis, SM, Babiuk, LA, Hancock, REW ndi Towers, GHN, 1995. Antiviral screening of British Columbian mankhwala.Journal of Ethnopharmacology, 49 (2), pp.101-110.
[xv] Jassim, SAA ndi Naji, MA, 2003. Novel antiviral agents: malingaliro a chomera chamankhwala.Journal of Applied Microbiology, 95 (3), pp.412-427.
[xvi] Luo, H., Tang, QL, Shang, YX, Liang, SB, Yang, M., Robinson, N. ndi Liu, JP, 2020. Kodi mankhwala aku China angagwiritsidwe ntchito popewa matenda a coronavirus 2019 (COVID -19)Kuwunikira zakale zakale, umboni wa kafukufuku ndi mapulogalamu apano opewera.Chinese Journal of Integrative Medicine, pp.1-8.
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Nthawi yotumiza: Apr-10-2020