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Dziko likukalamba.Koma kodi zakhala zathanzi?Bungwe loona za kalembera la anthu ku United States linaneneratu kuti ku United States kokha, okalamba opitirira 65 adzaposa chiwerengero cha ana.Bungweli likuti chaka cha 2030 ndi "chinthu chofunikira kwambiri chosinthira anthu m'mbiri yaku America," pomwe obereketsa ana adzakhala ndi zaka zopitilira 65.
Kuwonjezeka kwautali wa moyo wapadziko lonse lapansi, zovuta zachipatala ndi mayendedwe akukula kwa ogula osamala zaumoyo amapereka mwayi waukulu pamsika wowonjezera zakudya.
Kufunika kwa mankhwala oletsa mafuta opangira mafuta opangidwa ndi sayansi kukuyenera kupangidwa, ndipo chotetezachi chimathandizira kukalamba bwino ndipo chikhoza kuchedwetsanso ukalamba.NMN ndi molekyulu yotere.
NMN ndi mankhwala achilengedwe a vitamini B3 metabolism.Zitha kupezeka m'thupi lathu ndipo zimapezeka pang'ono muzakudya zina zathanzi, monga broccoli, edamame ndi peel nkhaka.NMN ndi metabolite yofunikira kuti ipange mphamvu ndikusunga moyo m'thupi la munthu.NMN ndiye kalambulabwalo wa molekyulu yofunika NAD +, yomwe imathandizira ntchito zosiyanasiyana zofunika pa thanzi komanso ukalamba wathanzi.Pakati pa zaka zapakati pa 40 ndi 60, mlingo wa NAD + mu minofu yaumunthu umatsika ndi 50%.Kutenga NMN kumatha kulimbikitsa kupanga kwachilengedwe kwa NAD + ndikuthandizira kuthana ndi ukalamba.
1. Kapangidwe kake ndi kosakhazikika.NMN ya m'badwo woyamba wocheperako ilibe madzi abwino.Effepharm's NMN version ya NMN idzachepetsa ndalama zopangira kupyolera mukuyenda bwino kwa ufa, potero kuonjezera mphamvu yopangira chifukwa zidzakhala zosavuta kugwiritsa ntchito makina.Kuphatikiza apo, popeza mtundu wocheperako ndi wovuta kusakaniza mofanana, mtundu uwu upangitsa kuti pakhale mulingo wofananira wa kapisozi.Potsirizira pake, ufa wochepa wa NMN woponderezedwa mwa mawonekedwe a mapiritsi umabalalika mosavuta panthawi yoyendetsa.
Makasitomala ambiri amayesa kuthetsa vutoli powonjezera zina zowonjezera, koma izi zapangitsa kuti mapiritsi akuluakulu, omwe si abwino kwambiri kwa ogula omwe ali ndi chiwerengero chachikulu cha anthu.Choncho, otsika kachulukidwe NMN ndi oyenera kokha ufa mankhwala formulations.
2. Miwiritsani zosakaniza za NMN zoipitsidwa.Tsoka ilo, msika wadzaza ndi NMN zabodza komanso zachinyengo.Chiyambireni NMN pamsika chaka chatha, mitundu yambiri ya NMN yatsopano yawonekera imodzi ndi ina.Ndizovuta kwa opanga ndi makasitomala athu kusiyanitsa zida zenizeni zapamwamba kuchokera kuzinthu zabodza komanso zotsika kwambiri zogulitsidwa pa intaneti.
Zogulitsa zina za NMN zogulitsidwa zimakhala ndi chiyero chochepera 80%.Makasitomala ndi makasitomala samadziwa kuti zodzaza kapena zoyipitsidwa zili mu 20% ina yazinthuzo.
Ndipotu, tapeza kuti ogulitsa ambiri a NMN amagulitsa nicotinamide (vitamini B3 wamba komanso wotsika mtengo) kapena amagulitsa nicotinamide ribose m'malo mwa NMN.Ngakhale ogulitsa ambiri amawonjezera ufa kuti achepetse NMN ndikunyenga makasitomala awo.Mankhwalawa nthawi zambiri amakhala otsika mtengo, koma alibe zotsatira zopindulitsa.
3. Kupanda deta otetezeka ndi ogwira.NMN ikukula kwambiri ku United States, Europe, Japan ndi China, komabe ilibe zambiri zotetezedwa komanso zothandiza.Anthu ambiri sakhulupirirabe malonda, kotero msika wa NMN nthawi zonse umakhala wochepa.Ndipotu, NMN poyamba ilipo m'thupi la munthu ndi masamba ena, monga broccoli, kotero palibe vuto la chitetezo.Koma tsopano ndi nthawi yotsimikiziranso zambiri.
Kuti mudziwe momwe mungapezere zinthu zokhazikika, zodalirika, zoyera komanso zotetezeka, mndandanda wa mayesero ndi kusanthula kunachitika.
Pofufuza momwe NMN imapangidwira ndikugwiritsa ntchito njira zoyendetsera ndalama ndi in-situ FTIR njira zowunikira, zimapezeka kuti NMN ili ndi mchere wamkati wamkati, ndipo isoelectric point ya mchere wamkati ndi chinthu chofunikira kwambiri pakusakhazikika kwa NMN.Monga molekyulu ya polar, madzi amayambitsa kusamutsidwa kwamagetsi ku NMN, motero kuwononga dongosolo la mchere la NMN lokhazikika.Ngati ndi choncho, NMN idzawonetsa mawonekedwe osinthika a metastable omwe amatha kuwonongeka, ndiko kuti, chinyezi mu mankhwala ndi mamolekyu amadzi aulere mumlengalenga adzawononga mwachindunji isoelectric point ya mchere wamkati ndikuchepetsa chiyero cha NMN.Uku ndikupambana kwakukulu mu kafukufuku wokhazikika wa NMN ndipo zikhala poyambira kukonza.
Pofuna kupititsa patsogolo kukhazikika kwa NMN yamkati, ofufuzawo adapanga NMN yatsopano yokhala ndi dongosolo lokhazikika komanso lophatikizika (Chithunzi 2: Utali: 3㎛-10㎛), ndipo adayambitsa mwapadera mbadwo watsopano wa NMN wochuluka kwambiri. .Poyerekeza ndi mawonekedwe a macheka a zinthu za m'badwo woyamba wa NMN (Chithunzi 3: Utali: 9㎛-25㎛), m'badwo wachiwiri wa NMN uli ndi zabwino ziwiri zosayerekezeka:
Kukhazikika kwamphamvu komanso moyo wautali wa alumali.Makonzedwe a malo a mtundu watsopano wa NMN wa NMN ndi wadongosolo komanso wophatikizika, amateteza bwino kukhudzana ndi madzi aulere mumpweya, potero amathandizira kukhazikika kwa NMN ndikukulitsa moyo wa alumali wamankhwala.Mosiyana ndi buku la NMN microstructure, mawonekedwe a zigzag a m'badwo woyamba amawonetsa kusokonezeka kwambiri komanso kuphatikizika, kotero kuti molekyu iliyonse imawululidwa kwambiri ndi mpweya ndikumwetsa madzi ambiri.
Kuchulukana kwake ndikwambiri, mlingo wake ndi wokhazikika, ndipo chilinganizocho chimakhala chosinthika.NMN yokonzedwa bwino komanso yophatikizika ya microscope imakhala ndi kuchuluka kwachulukidwe komanso kuchuluka kwamadzimadzi, kupewa mlingo wosakhazikika woyambitsidwa ndi fumbi panthawi yokonzekera.Kuonjezera apo, zidzakhudza mlingo wa yunifolomu wa capsule.Pa nthawi yomweyi, chifukwa chachiwiri cha NMN chimakhala ndi madzi abwino, chingathandize kuchepetsa nthawi yopangira komanso kuchepetsa mtengo wopangira kupanga.
Phindu la pH ndi madzi amayendetsedwa bwino.Kuonjezera apo, asidi osayenera kapena zinthu za alkali zidzawononga mphamvu yamagetsi mkati mwa slats, kotero pH ndi imodzi mwa zinthu zofunika kwambiri kuti mukhale okhazikika.Dr. Hu wa Effepharm poyamba adapeza kuti kusintha kwa pH kungathe kulamulira mkati mwa NMN, ndipo gulu lake lakhazikitsa mlingo wa golide wa pH womwe ukhoza kupititsa patsogolo mkati mwa NMN.Kuphatikiza apo, gululo limayendetsa madzi osachepera 1%.Ngati NMN poyamba imasunga madzi ochepa, kukhazikikako kudzakhalanso bwino kwambiri.
Payenera kukhala lipoti loyeserera la labotale la chipani chachitatu kuti litsimikizire kuti NNM ndi yoyera komanso yoyera.Gulu lililonse la zinthu zopangira liyenera kudziyesa mosamalitsa komanso kuyesa kwa chipani chachitatu.
Kutengera chiyero chachikulu, zonyansa ziyenera kuyendetsedwa mosamalitsa, pomwe zonyansa zamunthu sizidutsa 0,5%, komanso zonyansa zonse sizidutsa 1%.Zonyansa zonse zodziwika zikuphatikiza NR, nicotinamide, ribose, ndi zina zambiri, zomwe zavomerezedwa ndi FDA ngati zopangira chakudya.Kuphatikiza apo, zitsulo zolemera ndi tizilombo tating'onoting'ono ziyenera kuyendetsedwa mosamalitsa motsatira mfundo za USP mkati mwa malo otetezeka ndipo zitha kugwiritsidwa ntchito molimba mtima.Malipoti a mayeso a NMR ndi LC-MS angatsimikizirenso kuti NMN ndi yowona, yapamwamba komanso yoyera.
Pamene NMN ikukula kwambiri ku United States, Europe, Japan, China ndi madera ena a dziko lapansi, chitetezo ndi mphamvu zikukhala zofunika kwambiri.Padakali kusowa kwa chitetezo ndi chitetezo chokwanira, chomwe chimachepetsa kukula kwa NMN pamsika.Ino ndi nthawi yotsimikizira kuti NMN imagwira ntchito bwino pamayesero achipatala a anthu.Umu ndi momwe Effepharm akutsogolera.
Effepharm adayambitsa kafukufuku wapakati, wosasinthika, wakhungu kawiri, wopangidwa nthawi imodzi, kafukufuku woyendetsedwa ndi placebo kuti awone momwe NMN ikuyendera komanso chitetezo.Uku ndiye kuyesa kwachipatala kwa anthu kwakukulu kwambiri komanso kokwanira pa NMN mpaka pano.
Mlanduwu udzakhala ndi maphunziro a 66 ndipo udzatha kumapeto kwa 2020. Gawo loyamba la kuyesa kwa poizoni wa nyama yatha, ndipo zotsatira zoyesa zimasonyeza kuti Uthever NMN yathu ilibe poizoni woopsa.Kuphatikiza apo, kafukufuku wokhudza ntchito yatsopano ya NMN ngati khungu loteteza UV lamalizidwa, ndipo mapepala a SCI ndi ma patent adzasindikizidwa posachedwa.
Timaneneratu kuti padzakhala mazana amtundu wa NMN chaka chamawa.Pambuyo pake, aliyense adzakhala ndi phindu lamtengo wapatali ndipo gawo la msika lidzakhala lochepa.Malo ogulitsa osiyana okha ndi omwe angatsimikizire malonda ndikukhazikitsa chithunzi chamtundu wapadera.
Effepharm ali kale ndi gulu la akatswiri asayansi, ndipo ndife okhawo opanga zinthu za NMN omwe akuyesa chitetezo chachipatala ndikuchita bwino, zomwe zingakubweretsereni chithunzi chapamwamba kwambiri.Tikupanganso ntchito zatsopano komanso zosiyanasiyana za NMN, zomwe zingakuthandizeni kuti muzitha kusintha mwachangu ndikusintha kwa msika womwe ukukula mwachangu.
Posankha Uthever NMN, mutha kuwonetsetsa kuti mumapeza zinthu zokhazikika, zodalirika, zoyera komanso zotetezeka zomwe makasitomala angakhulupirire.Tikhoza kukuthandizani kukwaniritsa lonjezo la mnyamata wapadela ameneyu.
Zomwe zimaperekedwa ndi Effepharm (Shanghai) Ltd ndipo sizinalembedwe ndi gulu la akonzi la NutraIngredients-usa.com.Kuti mumve zambiri za nkhaniyi, lemberani Effepharm (Shanghai) Ltd.
Kulembetsa kwamakalata aulere Lowani nawo kalata yathu yaulere ndikutumiza nkhani zaposachedwa kubokosi lanu
Nthawi yotumiza: Nov-07-2020