PQQ Itha Kupewa Kufooka kwa Osteoporosis kuchokera ku Testosterone Deficiency mu Animal Study

Pyrroloquinoline quinone (PQQ), antioxidant yomwe imapezeka muzakudya monga kiwifruit, yapezeka kuti imapereka phindu ku thanzi la mafupa m'kafukufuku wam'mbuyomu, kuphatikiza kafukufuku wosonyeza kuti imalepheretsa osteoclastic bone resorption (osteoclastogenesis) ndikulimbikitsa mapangidwe a mafupa a osteoblastic (osteoblastogenesis).Koma zotsatira za kafukufuku wa zinyama zatsopano zapeza, kwa nthawi yoyamba, kuti chophatikiziracho chingalepheretsenso matenda osteoporosis oyambitsidwa ndi kusowa kwa testosterone.

Ngakhale kuti matenda osteoporosis okhudzana ndi kusintha kwa msambo ndi nkhani yodziwika bwino ya thanzi la amayi, testosterone-induced osteoporosis mwa amuna yapezeka kuti ikugwirizana ndi matenda aakulu ndi imfa pambuyo pa kusweka kwa osteoporotic fractures, ngakhale kuti imakonda kuchitika pambuyo pa moyo kuposa postmenopausal osteoporosis. mwa akazi.Komabe, mpaka pano, ofufuza anali asanafufuze ngati PQQ ingathandize kudwala matenda osteoporosis okhudzana ndi kuchepa kwa testosterone.

Polemba mu American Journal of Translational Research, olemba kafukufukuyo adanena kuti adaphunzira magulu awiri a mbewa.Gulu lina linapangidwa ndi orchidectomized (ORX; kuthena opaleshoni), pamene gulu lina linachitidwa opaleshoni yachinyengo.Kenako, kwa masabata 48 otsatirawa, mbewa pagulu la ORX adalandira zakudya zanthawi zonse kapena zakudya zanthawi zonse kuphatikiza 4 mg PQQ pa kilogalamu yazakudya.Gulu la mbewa za sham-surgery lidalandira chakudya chachibadwa chokha.

Kumapeto kwa nthawi yowonjezerapo, ofufuza adapeza kuti gulu la placebo la mbewa za ORX linali ndi kuchepa kwakukulu kwa kuchulukitsitsa kwa mafupa a mafupa, trabecular bone volume, osteoblast number, ndi collagen deposition poyerekeza ndi mbewa za sham.Komabe, gulu la PQQ silinachepetseko izi.Osteoclast pamwamba idachulukitsidwanso kwambiri mu gulu la ORX placebo poyerekeza ndi mbewa zamanyazi, koma idatsika kwambiri pagulu la PQQ.

"Kafukufukuyu adawonetsa kuti [PQQ] imathandizira kupewa kufooka kwa mafupa a testosterone poletsa kupsinjika kwa okosijeni ndi kuwonongeka kwa DNA, ma cell apoptosis, ndikulimbikitsa kufalikira kwa MSC ndikusiyanitsidwa ndi mafupa osteoblasts komanso kuletsa kuwonetsa kwa NF-κB m'mafupa kuti achepetse. osteoclastic bone resorption,” ofufuza anamaliza motero."Zotsatira zathu kuchokera ku kafukufukuyu zidapereka umboni woyesera wogwiritsa ntchito [PQQ] pochiza matenda osteoporosis mwa amuna okalamba."

Wu X et al., "Pyrroloquinoline quinone imalepheretsa kuchepa kwa testosterone chifukwa cha kufooka kwa mafupa polimbikitsa mapangidwe a mafupa a osteoblastic komanso kuletsa osteoclastic bone resorption," American Journal of Translational Research, vol.9, ayi.3 (March, 2017): 1230-1242

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