Chitetezo cha mthupi ndicho chotchinga chokhacho cholimba ku thanzi la thupi.Chitetezo cha mthupi chimagwira ntchito ngati “gulu lankhondo” m’thupi, kulimbana ndi “mdani” amene amaika thanzi lathu pangozi tsiku lililonse, koma nthawi zambiri sitimamva."Nkhondo" yoopsayi ndi chifukwa chakuti "gulu" ili ndi mwayi wokwanira.Chitetezo chikadzathyoledwa, thupi lathu "lidzasweka" ndipo mndandanda wa matenda udzawonekera, zomwe sizimangoika maganizo pa munthu payekha, komanso zimalemetsa banja.Kubwerezabwereza kwa mliri watsopano wa korona kwatsimikiziranso kufunika kwa chitetezo cha anthu.Kafukufuku wambiri watsimikizira kuti ginsenoside CK yakhala ikuchita bwino kwambiri pakuwongolera chitetezo chamunthu ndipo yakwanitsa kutuluka pamsika wazaumoyo.
Ku China, ginseng nthawi zonse imawonedwa ngati mfumu ya zitsamba ndipo imadziwika kuti "yopatsa thanzi komanso yolimbikitsa kwambiri Kum'mawa".Kumadzulo, ginseng amatchedwa PANAX CA MEYERGINSENG, "PANAX" amachokera ku Greek, kutanthauza "kuchiritsa matenda onse", ndipo "GINSENG" ndi matchulidwe achi China a ginseng.Ginseng ndi chomera chosatha cha herbaceous chamtundu wa Araliaceae ginseng.Zomera za mtundu wa Araliaceae zinachokera ku Cenozoic ndi Tertiary Period, pafupifupi zaka 60 miliyoni zapitazo.Pamene Quaternary Ice Age inafika, malo awo okhalamo adachepetsedwa kwambiri.Ginseng ndi ginseng Zomera zina zamtundu wamtunduwu zakhalapobe ngati zotsalira zakale.Izi ndizokwanira kusonyeza kuti ginseng imatha kupirira kuyesedwa kwa chilengedwe ndi nthawi, ndipo imathandizirabe thanzi laumunthu.
Ntchito yachikale "Dream of Red Mansions" imatchula "Ginseng Yangrong Pill", yomwe ndi mankhwala opatsa thanzi omwe Lin Daiyu amakonda kumwa.Lin Daiyu anali atangolowa kumene ku Jia Mansion, ndipo aliyense ankawoneka kuti ali ndi vuto, ndiye anamufunsa kuti chavuta ndi chiyani?Ndi mankhwala otani?Daiyu anamwetulira ndipo anati: “Tsopano ndimadyabe mapiritsi a ginseng Yangrong.”Kusakwanira ndi chitetezo chofooka m'mawu amakono, chomwe chimasonyeza ubwino wa ginseng pakuwongolera chitetezo chokwanira.Kuphatikiza apo, "Compendium of Materia Medica" ndi "Dongyibaojian" amalembanso zolemba zomwe zili ndi ginseng.
Kale, ginseng ankangosangalala ndi mafumu ndi anthu olemekezeka.Tsopano yathamangira ku Asia, ndikupanga "ginseng fever" padziko lonse lapansi.Ofufuza ochulukirapo komanso akatswiri ayamba kuphunzira za ginseng ndi zotuluka zina, ginseng extract ndi ginsenosides (Ginsenoside) ndi zina zotero.
Saponins ndi mtundu wa glycosides ndipo amapangidwa ndi sapogenin ndi shuga, uronic acid kapena ma organic acid.Ginsenosides ndiye gwero la ginseng, ndipo ndizomwe zimagwira ntchito kwambiri pamankhwala a ginseng, panax notoginseng ndi American ginseng.Pakadali pano, pafupifupi 50 ma ginsenoside monomers adzipatula.Ma ginsenosides omwe amachotsedwa mwachindunji motere amatchedwa prototype ginsenosides, kuphatikizapo Ra, Rb1, Rb2, Rb3, Re, Rg1, ndi zina zotero. Ma ginsenosides amtundu wa ginsenosides ayenera kuwola ndi michere yapadera ndikusandulika kukhala ginsenosides osowa asanayambe kuyamwa ndi kugwiritsidwa ntchito. thupi la munthu.Komabe, kuchuluka kwa enzymeyi m'thupi kumakhala kochepa kwambiri, motero kuchuluka kwa kagwiritsidwe ntchito ka thupi ka prototype ginsenoside ndikotsika kwambiri.
Ginsenoside CK (Compound K) ndi saponin yamtundu wa glycol, yomwe ili m'gulu la ginsenosides osowa.Pafupifupi kulibe mu ginseng wachilengedwe.Ndicho chinthu chachikulu chowonongeka cha ginsenosides Rb1 ndi Rg3 wambiri m'matumbo a munthu.Imakhala ndi zochita zambiri zachilengedwe komanso kuyamwa kwakukulu ndi thupi la munthu.Kumayambiriro kwa 1972, Yasioka et al.anapeza ginsenoside CK kwa nthawi yoyamba.Lingaliro la "natural prodrug" linatsimikiziranso ntchito yachilengedwe ya ginsenoside CK.Kafukufuku wambiri wawonetsa kuti ntchito zake zolimbana ndi chotupa komanso zolimbitsa thupi ndizolimba kwambiri pakati pa ma ginsenosides onse.
Kuyambira pomwe ginsenoside Rg3 idalowa pamsika, kuyankha sikunakhale kosangalatsa.Anthu ambiri sadziwa kuti ginsenoside Rg3, yomwe yakhala ikulonjeza nthawi zonse, kwenikweni ndi gawo losungunuka m'madzi ndi mafuta lomwe silingatengedwe mwachindunji ndi thupi la munthu, ndipo kugwiritsa ntchito kwake kumakhala kochepa kwambiri.Mosasamala kanthu kuti thupi limadya bwanji, zotsatira zake zimakhala zochepa.
Pofuna kuthana ndi vutoli, gulu la R&D la Amicogen lapeza kudzera muzoyeserera zambiri kuti tizilombo tating'onoting'ono m'thupi la munthu titha kusintha mawonekedwe a PPD a ginsenosides kukhala mawonekedwe a CK ndikuyamwa ndikuigwiritsa ntchito poyambitsa β-glucosaminease.Pambuyo pa zaka zisanu ndi chimodzi za kafukufuku wa mvula, gululo linapanga bwino ginsenoside CK kupyolera mu fermentation, kufunsira ukadaulo wofananira wa patent, ndikusindikiza mapepala ofananira.Poyerekeza ndi njira ya asidi-base hydrolysis ndi njira yosinthira ma enzyme, ili ndi zabwino zosayerekezeka potengera mtengo wopangira komanso kupanga kwakukulu kwamakampani.Pakati pawo, zomwe zili mu CK zimatha kufika ku 15%, ndipo zodziwika bwino ndi 3%.Kupanga makonda kutha kuchitidwa molingana ndi zomwe akufuna, ndipo kuchuluka kwake kumatha kusinthidwa 15%.Itha kufotokozedwa ngati kupambana kwakukulu pakufufuza kwa ginsenosides.
Chifukwa cha kubwera kwa ginsenoside CK, pali njira zambiri zofufuzira ndi malingaliro oteteza thanzi la thupi, ndipo ogwira ntchito ku R&D ambiri adzakhala ndi chidwi ndi ntchito yake.Ginsenoside CK sikuti imangokhala ndi gawo lofunika kwambiri pachitetezo cha chitetezo cha mthupi, komanso imakhala ndi chidziwitso chochuluka choyesera kuti ithandizire odana ndi khansa, odana ndi matenda a shuga, neuroprotective, kukumbukira kukumbukira komanso zotsatira za thanzi la khungu.M'tsogolomu, zinthu zambiri zotsogozedwa ndi ginsenoside CK zidzalowa m'mabanja masauzande ambiri kuti ateteze thanzi la mabanja awo.
Nthawi yotumiza: Sep-09-2021