DL-O-Phospho-L-serine Powder: Comprehensive Product Description

1. Product Overview

Chemical Name: DL-O-Phospho-L-serine
Synonyms: DL-SOP, DL-O-Phosphoserine, 2-Amino-3-hydroxypropanoic acid 3-phosphate 
CAS No.: 17885-08-4 (DL-form) / 407-41-0 (L-form) 
Molecular Formula: C₃H₈NO₆P
Molecular Weight: 185.07 g/mol

DL-O-Phospho-L-serine is a phosphorylated derivative of serine, serving as a critical endogenous metabolite in human biofluids. It plays dual roles in biochemical pathways: as a modulator of glutamate receptors and an inhibitor of glial cell proliferation, making it invaluable in neuroscience and metabolic research .

2. Chemical and Physical Properties

Key Properties:

• Appearance: White to off-white crystalline powder .
• Melting Point: 190°C (lit.) .
• Solubility:pH (1% solution): 1.5–2.5 .
  • Water: 50 mg/mL (hot, clear solution) .
  • DMSO: Insoluble (<1 mg/mL) .
• Storage:
  • Powder: -20°C for 3 years; avoid repeated freeze-thaw cycles.
  • Solution: -80°C for 1 year (short-term use at 4°C for 1 month) .

Structural Data:

• LogP: -1.86 .
• Polar Surface Area (PSA): 139.89 Ų .
• Refractive Index: 1.552 .

3. Applications in Research

3.1 Neurobiological Studies

• mGluR Agonist: Acts on metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) with EC₅₀ values of 2–5 μM, facilitating studies on synaptic plasticity and neurodegenerative diseases .
• NMDA Receptor Antagonist: Competitively inhibits NMDA receptors, offering potential in stroke and epilepsy research .

3.2 Cellular Regulation

• Inhibits Glial Proliferation: Suppresses Müller glial cell proliferation post-retinal photodamage, aiding retinal regeneration studies .
• Enhances Neuronal Differentiation: Promotes precursor cell differentiation into neurons, critical for neurogenesis research .

3.3 Metabolic Pathways

• Phosphorylation Signaling: Serves as a substrate for kinases in protein modification studies, pivotal for understanding cellular signal transduction .

4. Specifications and Quality Control

Analytical Standards:

Certifications:

• Batch-specific COA (Certificate of Analysis) provided.
• Traceable to NIST standards for research reproducibility.

5. Storage and Handling Guidelines

Transportation:

• Shipped with blue ice or dry ice to maintain stability .

Handling Precautions:

1. Personal Protection: Wear lab coats, gloves, and eye protection.
2. Solubility Protocol: Centrifuge powder briefly before dissolving in hot water (50–60°C) for optimal solubility .
3. Contraindications: For research use only; not for diagnostic or therapeutic applications .

6. Usage Recommendations

In Vitro Studies:

• Cell Culture: Use 1–10 μM concentrations for mGluR activation assays .
• Retinal Models: Apply 5 μM to inhibit cone cell regeneration in photodamage experiments .

Solution Preparation:

7. Keyword Integration:

“DL-O-Phospho-L-serine powder,” “Phosphoserine supplier,” “mGluR agonist.”

Buy high-purity Phosphoserine for neuroscience research.”